Abstract
a unique opportunity to study the effects of prolonged exposures to altitudes above 5,000 m was provided by the 1981 American Medical Research Expedition to Everest (AMREE). A detailed assessment of the fasting metabolic state, in which the levels of key metabolites and hormones were measured, was included in the program. Fourteen adult male subjects between the ages of 28 and 52 yr (mean = 36) were studied at sea level and again during exposures to altitudes of 5,400 m and 6,300 m. This chapter details the similarities and differences between previous studies at moderate altitudes and the AMREE findings at more extreme altitudes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
BLUME, F. D., AND N. PACE. Effect of translocation to 3,800 m altitude on glycolysis in mice. J. Appl. Physiol. 23: 75 - 79, 1967.
BLUME, F. D., AND N. PACE. Changes in tissue distribution of glucose radiocarbon at altitude. Federation Proc. 28: 933 - 936, 1969.
BLUME, F. D., AND N. PACE. The utilization of "C-labeled palmitic acid, alanine and aspartic acid at high altitude. Environ. Physiol. 1: 30 - 36, 1971.
BRAHMACHARI, H. D., M. S. MALHOTRA, S. JOSEPH, AND U. R. KRISHNAN. Glucose tolerance at high altitude in man. Indian J. Med. Res. 61: 411 - 415, 1973.
CHINN, K. S. K., AND J. P. HANNON. Efficiency of food utilization at high altitude. Federation Proc. 28: 944 - 947, 1969.
CHINN, K. S. K., AND J. P. HANNON. Effect of diet and altitude on the body composition of rats. J. Nutr. 100: 73 2738, 1970.
CONSOLAZIO, C. F., H. J. JOHNSON, AND J. H. KRZYWICKI. Body fluids, body composition and metabolic as- 20. pects of high altitude adaptation. In: Physiological Adaptation: Desert and Mountain,edited by M. K. Yousef, S. M. Howath, and R. W. Bullard. New York: Academic, 1972, 21. chapt. 16.
CONSOLAZIO, C. F., L. O. MATOUSH, H. L. JOHNSON, AND T. A. DAWS. Protein and water balances of young adults during prolonged exposure to high altitude (4300 meters). Am. J. Clin. Nutr. 21: 154 - 161, 1968.
DAS, H. K., AND N. C. CHOSH. Blood sugar levels in rats exposed to varying altitude stress for different periods of 22. time. Aerosp. Med. 47: 716 - 720, 1974.
DAVIDSON, M. B., AND V. S. AOKI. Fasting glucose 23. homeostasis in rats after chronic exposure to hypoxia. Am. J. Physiol. 219: 378 - 383, 1970.
DRAMISE, J. G., C. M. INOUYE, B. M. CHRISTENSEN, R. D. FULTS, J. E. CANHAM, AND C. F. CONSOLAZIO.
HANNON, J. P., C. J. KLAIN, D. M. SUDMAN, AND F. J. SULLIVAN. Nutritional aspects of high-altitude exposure in women. Am. J. Clin. Nutr. 29: 604 - 613, 1976.
HANNON, J. P., AND G. B. ROGERS. Body composition of mice following exposure to 4300 and 6100 meters. Aviat. Space Environ. Med. 46: 1232 - 1235, 1975.
HAYS, F. L., H. ARMBRUSTER, W. VETTER, AND W. BIANCA. Plasma cortisol in cattle: circadian rhythm and exposure to a simulated altitude of 5000 m. Int. J. Biometeor. 19: 127 - 135, 1975.
PUGH, L. G. C. E. Physiological and medical aspects of the Himalayan Scientific and Mountaineering Expedition 1960-61. Br. Med. J. 2: 621 - 627, 1962.
RASTOGI, G. K., M. S. MALHOTRA, M. C. SRIVASTAVA, R. C. SAWHNEY, G. L. DUA, K. SRIDHARAN, R. S. HOON, AND I. SINGH. Study of the pituitary-thyroid functions at high altitude in man. J. Clin. Endocrinol. Metab. 43: 447 - 452, 1977.
SCHNAKENBERG, D. D., L. F. KRABILL, AND P. C. WEISER. The anorexic effect of high altitude on weight gain, nitrogen retention and body composition of rats. J. Nutr. 101: 787 - 796, 1971.
SINGH, I., M. S. MALHOTRA, P. K. KHANNA, R. B. NANDA, T. PURSHOTTAM, T. N. UPADHYAY, U. RADHAKRISHNAN, AND H. D. BRAHMACHARI. Changes in plasma cortisol, blood antidiuretic hormone and urinary catecholamines in high-altitude pulmonary edema. Int. J. Biometeor. 18: 211 - 221, 1974.
32. SRIVASTAVA, K. K., M. M. L. KUMRIA, S. K. GROVER, K. SRIDHARAN, AND M. S. MALHOTRA. Glucose tolerance of lowlanders during prolonged stay at high altitude and among high altitude natives. Aviat. Space
Environ. Med. 46: 144-146, 1975.
SURKS, M. I. Effect of hypoxia and high altitude on thyroidal iodine metabolism in rats. Endocrinology 78: 307315, 1966.
SURKS, M. I. Effect of thyrotropin on thyroidal iodine metabolism during hypoxia. Am. J. Physiol. 216: 436 - 439, 1969.
SURKS, M. I., K. S. K. CHINN, AND L. O. MATOUSH. Alterations in body composition in man after acute exposure to high altitude. J. Appl. Physiol. 21: 1741 - 1746, 1966.
TIMIRAS, P. S., A. A. KRUM, AND N. PACE. Body and organ weights of rats during acclimatization to an altitude of 12,470 feet. Am. J. Physiol. 191: 598 - 604, 1957.
WHITTEN, B. K., AND A. H. JANOSKI. Effect of high altitude and diet on lipid components of human serum. Federation Proc. 28: 983 - 986, 1969.
YOUNG, A. J., W. J. EVANS, A. CYMERMAN, K. B. PANDOLF, J. J. KNAPIK, AND J. T. MAHER. Sparing effect of chronic high-altitude exposure on muscle glycogen utilization. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 52: 857 - 862, 1982.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 American Physiological Society
About this chapter
Cite this chapter
Duane Blume, F. (1984). Metabolic and Endocrine Changes at Altitude. In: West, J.B., Lahiri, S. (eds) High Altitude and Man. Clinical Physiology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7525-5_5
Download citation
DOI: https://doi.org/10.1007/978-1-4614-7525-5_5
Publisher Name: Springer, New York, NY
Online ISBN: 978-1-4614-7525-5
eBook Packages: Springer Book Archive