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Cerebral Microvascular Transport and Metabolism: Implications for Diabetes

  • Chapter
Hyperglycemia, Diabetes, and Vascular Disease

Part of the book series: Clinical Physiology Series ((CLINPHY))

Abstract

Diabetes mellitus affects many organs of the body. While the eyes, kidneys, cardiovascular system, and peripheral nervous system are most widely recognized to be harmed by diabetes, the impact of diabetes on the central nervous system (CNS) has gained attention only recently (172,213). Altered cerebral microvascular transport and metabolism may be relevant to three clinical areas in diabetes—stroke, hypoglycemia, and chronic cognitive dysfunction. Knowledge of the basic physiology of brain transport of glucose has mushroomed, especially since the cloning of the glucose-transport proteins. As a result, descriptive in vivo studies of physiology can now be extended, and precise molecular mechanisms underlying transport changes can be determined Recent studies also extend basic knowledge of how diabetes affects microvascular function and metabolism in the brain.

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Authors
  1. Anthony L. McCall
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Editors and Affiliations

  1. Diabetes and Metabolism Unit, Evans Memorial Department of Clinical Research and Department of Physiology, Boston University School of Medicine, Boston, Massachusetts, USA

    Neil Ruderman

  2. Department of Pathology, Washington University School of Medicine, St. Louis, Missouri, USA

    Joseph Williamson

  3. Diabetes Research Center and Departments of Medicine and Pathology, Albert Einstein College of Medicine, Bronx, New York, USA

    Michael Brownlee

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© 1992 American Physiological Society

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McCall, A.L. (1992). Cerebral Microvascular Transport and Metabolism: Implications for Diabetes. In: Ruderman, N., Williamson, J., Brownlee, M. (eds) Hyperglycemia, Diabetes, and Vascular Disease. Clinical Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7524-8_5

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  • DOI: https://doi.org/10.1007/978-1-4614-7524-8_5

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