Nonenzymatic Glycosylation of Macromolecules: Prospects for Pharmacologic Modulation

  • Hans-Peter Hammes
  • Michael Brownlee
Part of the Clinical Physiology Series book series (CLINPHY)


The primary factor associated with the development of most diabetic complications is prolonged exposure to hyperglycemia (7). The extent and rate of progression of retinopathy, nephropathy, and neuropathy correlate closely with the magnitude and duration of target tissue exposure to abnormally high levels of blood glucose. Data from ongoing prospective studies of selected diabetic populations also indicate a clear association with diabetic macrovascular complications. Current evidence suggests that a particular diabetic individual’s clinical course is also influenced by genetic determinants of tissue susceptibility and independent accelerating factors such as hypertension.


Amadori Product Mesangial Expansion Glycation Product Nonenzymatic Glycosylation Axonal Atrophy 
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© American Physiological Society 1992

Authors and Affiliations

  • Hans-Peter Hammes
  • Michael Brownlee

There are no affiliations available

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