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Rhythm Generation

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Respiratory Physiology

Part of the book series: People and Ideas ((PEOPL))

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Abstract

Several important scientific and technological advances made during the decades before World War II exerted great seminal influence on the study of respiratory physiology and the control of breathing.

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References

  1. Adamson S.L. Initiation of lung ventilation at birth. Fetal Med.Rev. 3: 133, 1991.

    Article  Google Scholar 

  2. Adrian E.D. Afferent impulses in the vagus and their effect on respiration. J. Physiol. (Lond.) 79: 332–358, 1933.

    CAS  Google Scholar 

  3. Adrian E.D. and D.W. Bronk. J. Physiol. (Lond.) 67: 119–151, 1929.

    Google Scholar 

  4. Adrian E.D. and Y. Zotterman. J. Physiol. (Lond.) 61: 151–171; 465–483, 1926.

    Google Scholar 

  5. Ahlfeld F.v. Ueber bisher noch nicht beschriebene intrauterine Bewegungen des Kindes. Verh. d. Gesamte Gynek. Leipzig: Breitkopf uns Hartel 203–210, 1888.

    Google Scholar 

  6. Ahlfeld, F.v. Die intrauterine Fätigkeit der Thorax-und Zwerchfellmuskulatur. Intrauterine Atmung. Monatschr. Geburtshilf. Gynek. 143–169, 1905.

    Google Scholar 

  7. Andersen P. and T.A. Sears. Medullary activation of intercostal fusimotor and alpha motoneurones. J. Physiol. (Lond.) 209: 739–755, 1870.

    Google Scholar 

  8. Arita H., N. Kogo, and K. Ichikawa. Locations of medullary neurons with nonphasic discharges excited by stimulation of central and/or peripheral chemoreceptors and by activation of nociceptors in cat. Brain Res. 442: 1–10, 1988.

    Article  PubMed  CAS  Google Scholar 

  9. Ashby W.R. An Introduction to Cybernetics. New York: Wiley, 1956.

    Google Scholar 

  10. Backman S. S., K. Anders, D. Ballantyne, H. Camerer, H. Dickhaus, D. Jordan, S. Miftin, D.W. Richter, N. Röhrig, and K.M. Spyer. Evidence for a monosynaptic connection between slowly adapting pulmonary stretch receptor afferents and inspiratory beta neurons. Pflugers Arch. 402: 129–136, 1984.

    Article  PubMed  CAS  Google Scholar 

  11. a.Balis U.J., K.F. Morris, J. Koleski, and B.G. Lindsey. Stimulations of a ventrolateral medullary neural network for respiratory rhythmogenesis inferred from spike train crosscorrelation. Biol.Cyber. 70: 311–327, 1994.

    Article  Google Scholar 

  12. Ballantyne D. and D.W. Richter. Post-synaptic inhibition of bulbar inspiratory neurones in the cat. J. Physiol. (Lond.) 348: 67–88, 1984.

    CAS  Google Scholar 

  13. Ballantyne D. and D.W. Richter. The non-uniform character of expiratory synaptic activity in expiratory bulbospinal neurones of the cat. J. Physiol. (Lond.) 370: 433–456, 1986.

    CAS  Google Scholar 

  14. Baumgarten R.v. and E. Kanzow. The interaction of two types of inspiratory neurons in the region of the tractus solitarius of the cat. Arch. Ital. Biol. 96: 361–373, 1953.

    Google Scholar 

  15. Benchetrit G., P. Baconnier, and J. Demongeot, editors. Concepts and Formalizations in the Control of Breathing. Manchester: Manchester University Press, 1987.

    Google Scholar 

  16. Berger A.J. Dorsal respiratory group neurons in the medulla of cat: Spinal projections, responses to lung inflation and superior laryngeal nerve stimulation. Brain Res. 135: 231–254, 1977.

    Google Scholar 

  17. Berger A.J. and K.A. Cooney. Ventilatory effects of kainic acid injection on the ventrolateral solitary nucleus. J. Appl. Physiol. 52: 131–140, 1982.

    PubMed  CAS  Google Scholar 

  18. Bertrand F., A. Hugelin, and J.F. Vibert. A stereologic model of pneumotaxic oscillator based on spatial and temporal distributions of neuronal bursts. J Neurophysiol. 37: 91–107, 1974.

    PubMed  CAS  Google Scholar 

  19. Bianchi A.L. and J.C. Barillot. Respiratory neurons in the region of the retrofacial nucleus: pontile, medullary, spinal and vagal projections. Neurosci. Lett. 31: 277–282, 1982.

    Article  PubMed  CAS  Google Scholar 

  20. Bianchi A. L., J. C. Barilot, and L. Grélot. Pattern of excitability of respiratory neurons in the region of the retrofacial nucleus. In: Neurobiology of the Control of Breathing, edited by C. von Euler and H. Lagercrantz. New York: Raven Press, 1987, pp. 149–155.

    Google Scholar 

  21. Bianchi A. L., L. Grélot, S. Iscoe, and J. E. Remmers. Electrophysiological properties of rostral medullary respiratory neurones in the cat: an intracellular study. J. Physiol. (Lond.) 407: 293–310, 1988.

    CAS  Google Scholar 

  22. Bongianni F., G. Fontana, and T. Pantaleo. Effects of electrical and chemical stimulation of the Bötzinger complex on respiratory activity in the cat. Brain Res. 445: 254–261, 1988.

    Article  PubMed  CAS  Google Scholar 

  23. Bongianni F., Corda M., Fontana G., and T. Pantaleo. Expiration-related neurons in the caudal ventral respiratory group of the cat: influences of the activation of Bötzinger complex neurons. Brain Res. 526: 299–302, 1990.

    Article  PubMed  CAS  Google Scholar 

  24. Bongianni F., M. Corda, G.A. Fontana, and T. Pantaleo. Reciprocal connections between rostral ventrolateral medulla and inspiration-related medullary areas in the cat. Brain Res. 565: 171–174, 1991.

    Article  CAS  Google Scholar 

  25. Bongianni F., M. Corda, G.A. Fontana, and T. Pantaleo. Excitatory and depressant respiratory responses to chemical stimulation of the rostral ventrolateral medulla in the cat. Acta Physiol. Scand., 148: 315–325, 1993.

    Article  PubMed  CAS  Google Scholar 

  26. Bongianni F., M. Corda, G.kA. Fontana, and T. Pantaleo. Chemical activation of caudal medullary expiratory neurones alters the pattern of breathing in the cat. J. Physiol. 474: 497–507, 1994.

    PubMed  CAS  Google Scholar 

  27. Botros S.M. and E.N. Bruce. Neural network implementation of a three-phase model of respiratory rhythm generation. Biol. Cybern. 63: 143–153, 1990.

    Article  PubMed  CAS  Google Scholar 

  28. Bradley G.W., C. v. Euler, I. Marttila, and B. Roos. A model of the central and reflex inhibition of inspiration in the cat. Biol. Cybern. 19: 105–116, 1975.

    Article  PubMed  CAS  Google Scholar 

  29. Breckenridge C. G. and H. E. Hoff. Pontine and medullary regulation of respiration in the cat. Am. J. Physiol. 160: 385–394, 1950.

    PubMed  CAS  Google Scholar 

  30. Breuer, J. Die Selbststeuerung der Atmung durch den Nervus vagus. Sitzungsber. Akad. Wiss. Wien Abt. 258: 909–937, 1868.

    Google Scholar 

  31. Brookhart J. M. The respiratory effects of localized faradic stimulation of the medulla oblongata. Am., J. Physiol. 129: 709–723, 1940.

    Google Scholar 

  32. Brown T.G. On the nature of the fundamental activity of the nervous centres; together with an analysis of the conditioning of the rhythmic activity in progression and a theory of the evolution of function in the nervous system. J. Physiol. (Lond.) 48: 18–46, 1914.

    CAS  Google Scholar 

  33. Budzinska K., C. v. Euler, F. F. Kao, T. Pantaleo, and Y. Yamamoto. Effects of graded focal cold block in rostral areas of the medulla. Acta Physiol. Scand. 124: 329–430, 1985.

    Article  PubMed  CAS  Google Scholar 

  34. Budzinska K., C. v. Euler, E. F. Kao, T. Pantaleo, and Y. Yamamoto. Effects of graded focal cold block in the solitary and para-ambigual regions of the medulla in the cat. Acta Physiol. Scand. 124: 317–328, 1985.

    Article  PubMed  CAS  Google Scholar 

  35. Camerer H., D.W. Richter, N. Röhrig, and M. Meesmann. Lung stretch receptor inputs to R-alpha-neurones: a model for “respiratory gating.” In: Central Nervous Control Mechanisms in Breathing, edited by C. von Euler and H. Lagercrantz. Wenner-Gren International Symposium Series, vol 32. Oxford, Pergamon Press, 1979, pp. 261–266.

    Google Scholar 

  36. Cannon W.B. The Wisdom of the Body 2 ed. New York: W.W. Norton, 1939.

    Google Scholar 

  37. Cherniack N.S. Potential role of optimization in alveolar hypoventilation and respiratory instability. In: Neurobiology of the Control of Breathing, edited by C. von Euler and H. Lagercrantz. Wenner-Gren International Symposium Series. New York: Raven Press, 1987, pp. 45–50.

    Google Scholar 

  38. Cherniack N.S., C. v. Euler, I. Homma, and F.F. Kao. Graded changes in central chemoceptor input by local temperature changes on the ventral surface of medulla. J. Physiol (Lond.) 287: 191–211, 1979.

    CAS  Google Scholar 

  39. Clark F.J. and C. v. Euler. On the regulation of depth and rate of breathing. J. Physiol. (Lond.) 222: 267–295, 1972.

    CAS  Google Scholar 

  40. Cohen M.I. Intrinsic periodicity of the pontile pneumotaxic mechanism. Am. J. Physiol 195: 23–27, 1958.

    PubMed  CAS  Google Scholar 

  41. Cohen M.I. Switching of the respiratory phases and evoked phrenic responses produced by rostral pontine electrical stimulation. J. Physiol. (Lond.) 217: 133–158, 1971.

    CAS  Google Scholar 

  42. Cohen, M.I. Neurogenesis of respiratory rhythm in the mammal. Physiol. Rev. 59: 1105–1173, 1979.

    PubMed  CAS  Google Scholar 

  43. Cohen M.I. Central determinants of respiratory rhythm. Annu. Rev. Physiol. 43: 9 1104, 1981.

    Google Scholar 

  44. Cohen M.I. and J.L. Feldman. Discharge properties of dorsal medullary inspiratory neurones: relation to pulmonary afferent and phrenic efferent discharge. J. Neurophsiol. 51: 753–776, 1984.

    CAS  Google Scholar 

  45. Cohen M.I., W.-X. Huang, R. Barnhart and W. R. See. Timing of medullary late-inspiratory neuron discharges: Vagal afferent effects indicate possible off-switch function. J. Neurophsiol. 69: 1784–1787, 1993.

    CAS  Google Scholar 

  46. Cohen M.I. and S.C. Wang. Respiratory neuronal activity in pons of cat. J. Neurophysiol. 22: 33–50, 1959.

    PubMed  CAS  Google Scholar 

  47. Dawes G.S. The rediscovery of fetal breathing movements and its consequences. In: Respiratory Control and Lung Development in the Fetus and Newborn. Edited by B.M. Johnston and P.D. Gluckman, Ithaca NY: Perinatology Press, 1986, pp. 209–222.

    Google Scholar 

  48. Dawes G.S., H. E. Fox, B. M. Leduc, G. C. Liggins, and R. T. Richards. Respiratory movements and paradoxical sleep in the foetal lamb. J. Physiol. (Lond.) 210: 47–48P, 1970.

    Google Scholar 

  49. Denny-Brown D. Nature of postural reflexes. Proc. R. Soc., B. 104: 252–301, 1929.

    Article  Google Scholar 

  50. Dillon G.H., D.E. Welsh, and T.G. Waldrop. Modulation of respiratory reflexes by an excitatory amino acid mechanism in the ventrolateral medulla. Respir. Physiol. 85: 55–72, 1991.

    Article  PubMed  CAS  Google Scholar 

  51. DiMarco A. F., C. v. Euler, J.R. Romaniuk, and Y. Yamamoto. Positive feedback facilitation of external intercostal and phrenic inspiratory activity by pulmonary stretch receptors. Acta Physiol. Scand. 113: 375–386, 1981.

    Article  PubMed  CAS  Google Scholar 

  52. DiMarco A.F., C. v. Euler, J.R. Romaniuk, and Y. Yamamoto. Immediate changes in ventilation and respiratory pattern associated with onset and cessation of locomotion in the cat. J. Physiol. (Lond.) 343: 1–16, 1983.

    CAS  Google Scholar 

  53. Eccles J.D. The ionic mechanism of ostsynaptic inhibition: Nobel lecture in physiology or medicine 1963. In: Nobel Foundation Nobel Lectures—Physiology or Medicine 19631970, Amsterdam: Elsevier, 1972, pp. 6–31.

    Google Scholar 

  54. Edelman G.M. Group selection and phasic recurrent signalling: a theory of higher brain function. In: The Mindful Brain, edited by G.M. Edelman and V.B. Mountcastle. Cambridge, MA: MIT Press, 1982, pp. 51–100.

    Google Scholar 

  55. Elam M., T. Yao, R Thorén, and T. H. Svensson. Hypercapnia and hypoxia: chemoreceptor-mediated control of locus coeruleus neurons and splanchnic, sympathetic nerves. Brain Res. 22: 373–381, 1981.

    Article  Google Scholar 

  56. Eldridge F.L., D.E. Millhorn, and T.G. Waldrop. Exercise hyperpnea and locomotion: parallel activation from the hypothalamus. Science 211: 844–846, 1981.

    Article  PubMed  CAS  Google Scholar 

  57. Errchidi S., R. Monteau, and G. Hilaire. Noradrenergic modulation of the medullary rhythm generator in the new born rat: an in vitro study. J. Physiol. (Lond.) 443: 477–498, 1991.

    CAS  Google Scholar 

  58. Euler, C. v. The control of respiratory movement. In: Breathlessness, edited by J.B.L. and E. J.M. Campbell. Oxford: Blackwell Scientific Publications, 1966, pp. 19–32.

    Google Scholar 

  59. Euler C. v. On the role of proprioceptors in perception and execution of motor acts with special reference to breathing. In: Loaded Breathing, edited by L.D. Pengelly, A.S. Rebuck, and E.J.M. Campbell. Ontario: Longman Canada, 1974, pp. 139–149.

    Google Scholar 

  60. Euler C. v. Introduction: Forebrain control of breathing behaviour. In: Respiratory Psychophysiology, edited by C. von Euler and M. Katz-Salamon. Wenner-Gren International Symposium Series, vol. 50. Basingstoke: The Macmillan Press, 1988, pp. 1–14.

    Google Scholar 

  61. Euler C. v. Brainstem mechanisms for generation and control of breathing pattern. In: Handbook of Physiology. The Respiratory System, vol. 2, Control of Braeathing, ch. 1, edited by N.S. Cherniack and J.G. Widdicombe. Bethesda, MD: American Physiological Society, 1986, pp. 1–67.

    Google Scholar 

  62. Euler C. v. Neural organization and rhythm generation. In: Crystal, R.G., West, J.B. eds. The Lung: Scientific Foundations edited by R.G. Crystal and J.B. West. Second ed. New York: Raven Press, 1996 (in press).

    Google Scholar 

  63. Euler, C. v. and U. Söderberg. Medullary chemo-sensitive receptors. J. Physiol. (Lond.) 118: 545–554, 1952.

    Google Scholar 

  64. Euler C. v. and T. Trippenbach. Excitability changes of the inspiratory “off-switch” mechanism tested by electrical stimulation in nucleus parabrachialis in the cat. Acta Physiol. Scand. 97: 175–188, 1976.

    Article  Google Scholar 

  65. Euler U.S. v., G. Liljestrand, and Y. Zotterman. Über den Reizmechanismus der Chemorezeptoren in Glomus caroticum. Acta Physiol. Scand. 1: 383–385, 1941.

    Article  Google Scholar 

  66. Ezure D. Synaptic connections between medullary respiratory neurons and considerations on the genesis of respiratory rhythm. Prog. Neurobiol. 35: 429–450, 1990.

    Article  PubMed  CAS  Google Scholar 

  67. Fedorko L. and E.G. Merrill. Axonal projections from the rostral expiratory neurones of the Bötzinger complex to medulla and spinal cord in the cat. J. Physiol. (Lond.) 350: 487496, 1984.

    Google Scholar 

  68. Feldman J.L. and M.I. Cohen. Relation between expiratory duration and rostral medullary expiratory neuronal discharge. Brain Res. 141: 172–178, 1978.

    Article  PubMed  CAS  Google Scholar 

  69. Felman J. L., M.I. Cohen, and R. Wolotsky. Phasic pulmonary afferent activity drastically alters the respiratory modulation of neurons in the rostral pontine pneumotaxic centre. In: Respiratory Centres and Afferent Systems, edited by B. Duron. Vol. 59. Paris: INSERM, 1976, pp. 95–105.

    Google Scholar 

  70. Feldman J. L., M.I. Cohen, and R. Wolotsky. Powerful inhibition of pontine respiratory neurons by pulmonary afferent activity. Brain Res. 104: 341–346, 1976.

    Article  PubMed  CAS  Google Scholar 

  71. Feldman J.L., D.R McCrimmon, and D.F. Speck. Effect of synchronous activation of medullary inspiratory bulbo-spinal neurones on phrenic nerve discharge in cat. J. Physiol. (Lond.) 347: 241–254, 1984.

    CAS  Google Scholar 

  72. Feldman J.L., D. R McCrimmon, H.H Ellenberger, J.C. Smith, and D.F. Speck. Generation of respiratory pattern in mammals. In: Neural Control of Rhythmic Movements in Vertebrates, edited by A.H. Cohen, S. Grillner, and S. Rossignol. New York: John Wiley and Sons, 1988, pp. 73–100.

    Google Scholar 

  73. Feldman J.L. and D.F. Speck. Interactions among inspiratory neurons in dorsal and ventral respiratory groups in cat medulla. J. Neurophysiol. 49: 472–490, 1983.

    PubMed  CAS  Google Scholar 

  74. Feldman J. L., U. Windhorst, K. Anders, and D. W. Richter. Synaptic interaction between medullary respiratory neurones during apneusis induced by NMDA-receptor blockade in cat. J. Physiol. 450: 303–323, 1992.

    PubMed  CAS  Google Scholar 

  75. Fenn W.O. Introductory remarks. Ann. NY Acad. Sci. 109: 415–417, 1963.

    Article  Google Scholar 

  76. Foutz A.S., J. Champagnat, M. Denavit-Saubiè. Involvement of N-Methyl-D-aspartate (NMDA) receptors in respiratory rhythmogenesis. Brain Res. 500: 199–208, 1989.

    Article  PubMed  CAS  Google Scholar 

  77. Gad J. Über das Athmungscentrum in der Medulla oblongata. Arch. Anat. Physiol. 17: 175–184, 1893.

    Google Scholar 

  78. Gesell R., C. S. Magee, and J.W. Bricker. Activity patterns of the respiratory neurons and muscles. Am. J. Physiol. 128: 615–628, 1940.

    Google Scholar 

  79. Getting P.A. Emerging principles governing the operation of neural networks. Annu. Rev. Neurosci. 12: 185–204, 1989.

    Article  PubMed  CAS  Google Scholar 

  80. Granit R., editor. Muscular Afferents and Motor Control-Nobel Symposium I. New York: John Wiley and Sons, 1966.

    Google Scholar 

  81. Greer J.J., J. C. Smith, and J. L. Feldman. Role of excitatory amino acids in the generation and transmission of respiratory drive in neonatal rat. J. Physiol.(Lond.) 437: 727–749, 1991.

    CAS  Google Scholar 

  82. Greer J.J., J. C. Smith, and J. L. Feldman. Glutamate release and presynaptic action of AP4 during inspiratory drive to phrenic motoneurons. Brain Res. 576: 355–357, 1992.

    Article  PubMed  CAS  Google Scholar 

  83. Grélot L., A.L. Bianchi, S. Iscoe, and J. E. Remmers. Expiratory neurones of the rostral medulla: anatomical and functional correlates. Neurosci. Lett. 89: 140–145, 1988.

    Article  PubMed  Google Scholar 

  84. Grillner S. Control of locomotion in bipeds, tetrapods, and fish. In: Handbook of Physiology. The Nervous System,edited by J.M. Brookhart and V.B. Mountcastle. Section 1, vol. II, pt. 2, ch. 26. Bethesda, MD: American Physiological Society, 1981, pp. 11791236.

    Google Scholar 

  85. Grillner S., J. Buchanan, L. Brodin, N. Dale, R. Hill, and P. Wallén. Transmitters, membrane properties and network circuitry in the control of locomotion in lamprey. Trends Neuro Sci. 10: 34–41, 1987.

    Article  CAS  Google Scholar 

  86. Grillner S., T. Matsushima. The neural network underlying locomotion in lamprey-synaptic and cellular mechanisms. Neuron. 7: 1–15, 1991.

    Article  PubMed  CAS  Google Scholar 

  87. Grodins F. S. Analysis of factors concerned in regulation of breathing in exercise. Physiol. Rev. 20: 220–239, 1950.

    Google Scholar 

  88. Grodins F.S., and S.M. Yamashiro. What is the pattern of breathing regulated for? In: Central Nervous Control Mechanisms in Breathing, edited by C. von Euler and H. Lagercrantz. Wenner-Gren Center International Symposium Series. Vol. 32. Oxford: Pergamon, 1979, pp. 169–176.

    Google Scholar 

  89. Haji A., J.A. Remmers, and R. Takeda. Effects of glycine and GABA on bulbar respiratory neurons of cat. J. Neurophysiol. 63: 955–965, 1990.

    PubMed  CAS  Google Scholar 

  90. Haji A., R. Takeda, and J.A. Remmers. Evidence that glycine and GABA mediate postsynaptic inhibition of bulbar respiratory neurons in the cat. J.Appl. Physiol. 73: 2333–2342, 1992.

    PubMed  CAS  Google Scholar 

  91. Hayashi F. and J. Lipski. The role of inhibitory amino acids in control of respiratory motor output in arterially perfused rat. Respir. Physiol. 89: 47–63, 1992.

    Article  PubMed  CAS  Google Scholar 

  92. Hering E. Die Selbststeuerung der Atmung durch den Nervus vagus. Sitzungsber. Akad. Wiss. Wein Abt. 257: 672–677, 1868.

    Google Scholar 

  93. Hertzberg T., S. Hellström, H. Lagercrantz, and J.M. Pequignot. Development of the arterial chemoreflex and turnover of carotid body catecholamines in the newborn rat. J. Physiol. (Lond.) 425: 211–225, 1990.

    CAS  Google Scholar 

  94. Heyman C. The part played by vascular presso-and chemo-receptors in respiratory control. In: Nobel Lectures-Physiology or Medicine (1922–1941). Amsterdam: Elsevier, 1965, pp. 460–481.

    Google Scholar 

  95. Hilaire G., A. L. Bianchi, and R. Monteau. A cross-correlation study of interaction among respiratory neurons of dorsal, ventral and retrofacial groups in cat medulla. Brain Res. 302: 19–31, 1984.

    Article  PubMed  CAS  Google Scholar 

  96. Hoff H. E. and C.G. Breckenridge. The medullary origin of respiratory periodicity in the dog. Am. J. Physiol. 158: 157–172, 1949.

    PubMed  CAS  Google Scholar 

  97. Hukuhara T. Jr. Functional organization of brain stem respiratory neurons and its modulation induced by afferences. In: Respiratory Centres and Afferent Systems, edited by B. Duron. Vol. 59. Paris: INSERM, 1976, pp. 41–53.

    Google Scholar 

  98. Huszczuk A. A respiratory pump controlled by phrenic nerve activity (abstract). J. Physiol. (Lond.) 210: 183P - 184P, 1970.

    CAS  Google Scholar 

  99. Jiang C. and J. Lipski. Extensive monosynaptic inhibition of ventral respiratory group neurons by augmenting neurons in the Bötzinger complex in the cat. Exp. Brain Res. 81: 639–348, 1990.

    Article  PubMed  CAS  Google Scholar 

  100. Johnson S.M. and P.A. Getting. Electrophysiological properties of neurons within the nucleus ambiguus of adult guinea pigs. J. Neurophysiol. 66: 744–761, 1991.

    PubMed  CAS  Google Scholar 

  101. Johnston B.M. and Gluckman P.D. Respiratory control and lung development in the fetus and newborn. New York: Penguin Press, 1986

    Google Scholar 

  102. Kalia M.P. Anatomical organization of central respiratory neurons. Annu. Rev. Physiol. 43: 105–120, 1981.

    Google Scholar 

  103. Kalia M. and D.W. Richter. Morphology of physiologically identified slowly adapting lung stretch receptor afferents stained with intro-axonal HRP in the nucleus of the tractus solitarius of the cat. I. A Light Microscopic Analysis. J. Comp. Neurol. 241: 503–520, 1985.

    Article  PubMed  CAS  Google Scholar 

  104. Kalia M. and D.W. Richter. Rapidly adapting pulmonary receptor afferents: II. Arborization in the nucleus of the tractur solitarius. J. Comp. Neurol. 274: 560–573, 1988.

    Article  PubMed  CAS  Google Scholar 

  105. Karczewski W.A. and H. Gromysz. The “split respiratory centre”: lessons from brainstem transections. In: Advances in Physiological Sciences. Respiration, edited by L. Hutas and L.A. Debreczeni. Vol. 10. Oxford: Pergamon Press, 1981, pp. 587–594.

    Google Scholar 

  106. Klages S., M.C. Bellingham, and D.W. Richter. Late expiratory inhibition of stage 2 expiratory neurons in the cat-a correlate of expiratory termination. J. Neurophysiol. (in press).

    Google Scholar 

  107. Knox C.K., Characteristics of inflation and deflation reflexes during expiration in the cat. J. Neurophysiol. 36: 284–295, 1973.

    PubMed  CAS  Google Scholar 

  108. Knox C.K. Reflex and central mechanisms controlling expiratory duration. In: Central Nervous Control Mechanisms in Breathing. edited by C. von Euler and H. Lagercrantz. Oxford: Pergamon Press, 1979, pp. 203–216.

    Google Scholar 

  109. Lagercrantz H. Neuromodulators and respiratory control during development. Trends Neurosci. 10: 368–372, 1987.

    Article  CAS  Google Scholar 

  110. Lagercrantz H., J. Pequignot, J. -M.Pequignot, and L. Peyrin. The first breaths of air stimulate noradrenaline turnover in the newborn rat. Acta Physiol. Skand. 144: 433438, 1992.

    Google Scholar 

  111. Lagercrantz H. and T. Slotkin. The stress of being born. Sci. Am. 254: 100–107, 1986.

    Article  PubMed  CAS  Google Scholar 

  112. Lagercrantz H. and M. Srinivasan. Development and function of neurotransmitter/ modulator systems in the brain stem. In:The Fetal and Neonatal Brain Stem: Developmental and Clinical Issues, edited by M.A. Hanson. Cambridge: Cambridge University Press, 1991, pp. 1–20.

    Google Scholar 

  113. Lindsey B.G., L. S. Segers, and R. Shannon. Functional associations among simultaneously monitored lateral medullary respiratory neurons in the cat. II. Evidence for inhibitory actions of expiratory neurons. J. Neurophysiol. 57: 1101–1117, 1987.

    Google Scholar 

  114. Lipski J., K. Ezure, and R.B. Wong She. Identification of neurons receiving input from pulmonary rapidly adapting receptors in the cat. J. Physiol. (Lond.) 443: 55–77, 1991.

    CAS  Google Scholar 

  115. Lipski J., L. Kubin, and J. Jodkowski. Synaptic action of R-ß neurons on phrenic motoneurons studied with spike-triggered averaging. Brain Res. 288: 105–118, 1983.

    Article  PubMed  CAS  Google Scholar 

  116. Lipski J. and E.G. Merrill. Electrophysiological demonstration of the projection from expiratory neurones in rostral medulla to contralateral dorsal respiratory group. Brain Res. 197: 521–524, 1980.

    Article  PubMed  CAS  Google Scholar 

  117. Loeschcke H. H. Central chemosensitivity and the reaction theory. Review lecture. J. Physiol. (Lond.) 332: 1–24, 1982.

    CAS  Google Scholar 

  118. Long S., and J. Duffin. The neuronal determinants of respiratory rhythm. Prog. Neurobiol 27: 101–182, 1986.

    Article  PubMed  CAS  Google Scholar 

  119. Lumsden T. Observations on the respiratory centres in the cat. J. Physiol. (Lond.) 57: 153–160, 1923.

    CAS  Google Scholar 

  120. Lumsden T. Observations on the respiratory centres. J. Physiol. (Lond.)57: 354–367, 1923.

    Google Scholar 

  121. Lumsden T. The regulation of respiration. Part I. J Physiol. (Lond.) 58: 81–91, 1923.

    CAS  Google Scholar 

  122. Lydic R. and J. Orem. Respiratory neurons of the pneumotaxic center during sleep and wakefulness. Neurosci. Lett. 15: 187–192, 1979.

    Article  PubMed  CAS  Google Scholar 

  123. Machin K. E. Feedback theory and its application to biological systems. Symp. Soc. Exp. Biol. 18: 441–446, 1964.

    Google Scholar 

  124. Magoun H.W. and R. Rhines. An inhibitory mechanism in the bulbar reticular formation. J. Neurophysiol 9: 165–171, 1946.

    PubMed  CAS  Google Scholar 

  125. Merlet C., J. Hoerter, C. Devilleneuve, and C. Tchobroutsky. Mise en evidence de mouvements respiratoire chez le foetus d’agneau in utero au cours du dernier mois de la gestation. C. R. Acad. Sci. Paris 270: 2462–2464, 1970.

    CAS  Google Scholar 

  126. Merrill E.G. The lateral respiratory neurons of the medulla: their associations with ucleus ambiguus, nucleus retroambivalis, the spinal accessory nucleus and the spinal cord. Brain Res. 24: 11–28, 1970.

    Article  PubMed  CAS  Google Scholar 

  127. Merrill E.G. Finding a respiratory function for the medullary respiratory neurons. In: Essays on the Nervous System, edited by R. Bellairs and E.G. Gray. Oxford: Clarendon Press, 1974, pp. 451–486.

    Google Scholar 

  128. Merrill E.G. Is there reciprocal inhibition between medullary inspiratory and expiratory neurones? In: Central Nervous Control Mechanisms in Breathing, edited by C. von Euler and H. Lagercrantz. Wenner-Gren International Symposium Series, vol. 32. Oxford: Pergamon Press, 1979, pp. 239–254.

    Google Scholar 

  129. Merrill E.G., L. Fedorko, L. Kubin, and J. Lipski. Origin of the expiratory inhibition of nucleus tractus solitarius inspiratory neurones. Brain Res. 263: 43–50, 1983.

    Article  PubMed  CAS  Google Scholar 

  130. Mitra J., N. Prabhakar, T. Pantaleo, Y. Yamamoto, M. Runold, E. v. Lunteren, C. v. Euler, and N. S. Cherniack. Do structures in the region of nucleus paragigantocellularis (nPG) integrate and mediate ventilatory drive inputs? Vol. 12, p. I. Society for Neuroscience Abstracts (16th Annual Meeting) 1986, p. 304.

    Google Scholar 

  131. Morin-Surun M., E. Boudinot, E. Champagnat, and M. Denavit-Saubié. Differentiation of two respiratory areas in the cat medulla using kainic acid. Respir. Physiol. 58: 323–334, 1984.

    Article  PubMed  CAS  Google Scholar 

  132. Nashner L. M. Organization and programming of motor activity during posture control. In: Reflex Control of Posture and Movement, Progress in Brain Research, edited by R. Granit and O. Pompeiano. Vol. 50. Amsterdam: Elsevier, 1979, pp. 177–184.

    Google Scholar 

  133. Ngai S.H. and S. C. Wang. Organization of central respiratory mechanisms in the brain stem of the cat localization by stimulation and destruction. Am. J. Physiol. 190: 343–349, 1957.

    PubMed  CAS  Google Scholar 

  134. Ogilvie M.D., A. Gottschalk, K. Anders, D.W. Richter, and A. I. Pack. A network model of respiratory rhythmogenesis. Am. J. Physiol. 263: R962 - R975, 1992.

    PubMed  CAS  Google Scholar 

  135. Onimaru H. and I. Homma. Respiratory rhythm generator neurons in medulla of brainstem-spinal cord preparation from newborn rat. Brain Res. 403: 308–384, 1987.

    Article  Google Scholar 

  136. Onimaru H., A. Arata, I. Homma. Firing properties of respiratory rhythm generating neurons in the absence of synaptic transmission in rat medulla in vitro. Exp. Brain Res. 76: 530–536, 1989.

    Article  PubMed  CAS  Google Scholar 

  137. Onimaru H. and I. Homma. Whole cell recordings from respiratory neurons in the medulla of brain stem-spinal cord preparations isolated from newborn rats. Pfluegers Arch. 420: 399–406, 1992.

    Article  CAS  Google Scholar 

  138. Orem J. The activity of late inspiratory cells during the behavioral inhibition of inspiration. Brain Res. 458: 224–230, 1988.

    Article  PubMed  CAS  Google Scholar 

  139. Orem J. and R.H. Trotter. Postinspiratory neuronal activities during behavioral control, sleep, and wakefulness. J. App J. Physiol. 72 (6): 2369–2377, 1992.

    CAS  Google Scholar 

  140. a.Otsuka H., S.G. E. Lindahl, H. Lagercrantz, and Y. Yamamoto. Effects of NMDA and non-NMDA receptor antagonists on inspiratory neurons in the in vitro brain stem-spinal cord preparation of newborn rat. Neurosci. Lett. 171: 94–96, 1994.

    Article  Google Scholar 

  141. Pantaleo T. and M. Corda. Expiration-related neurons in the region of the retrofacial nucleus: vagal and laryngeal inhibitory influences. Brain Res. 359: 343–356, 1985.

    Article  PubMed  CAS  Google Scholar 

  142. a.Pantaleo T. and M. Corda. Respiration-related neurons in the medial nuclear complex of the cat. Respir. Physiol. 64: 135–148, 1986.

    Article  Google Scholar 

  143. Pitts R. F. The differentiation of respiratory centers. Am. J. Physiol. 134: 192–201, 1941.

    Google Scholar 

  144. Poon C.S. Optimal control of ventilation in hypoxia, hypercapnia and exercise. In: B.J. Whipp and D.M. Wiberg. Modelling and Control of Breathing edited by Amsterdam: Elsevier, New York, 1983, pp. 189–196.

    Google Scholar 

  145. Poon C. Optimal control of ventilation in hypercapnia and exercise: an extended model. In: Concepts and Formalizations in the Control of Breathing, edited by G. Benchetrit, R. Baconnier, and J. Demongeot. Manchester: Manchester University Press, 1987, pp. 119–131.

    Google Scholar 

  146. Prabhakar N.R. Significance of excitatory and inhibitory neurochemicals in hypoxic chemotransmission of the carotid body. In: Control of Breathing: Modelling and Perspectives edited by Y. Honda. New York: Plenum Press, 1992.

    Google Scholar 

  147. Prabhakar N.R., G.K. Kumar, C.H. Chang, F.H. Agani, and M.A. Haxhiu. Nitric oxide in the sensory function of the carotid body. Brain Res. 625: 16–22, 1993.

    Article  PubMed  CAS  Google Scholar 

  148. Prabhakar N. R., J. Mitra, and N.S. Cherniack. Role of substance P in hypercapnic excitation of carotid chemoreceptors. J. Appl. Physiol. 63: 2418–2425, 1987.

    PubMed  CAS  Google Scholar 

  149. Remmers J. E., J. P. Baker Jr, and M. K. Younes. Graded inspiratory inhibition: the first stage of inspiratory “off-switching.” In: Central Nervous Control Mechanisms in Breathing, edited by C. von Euler and H. Lagercrantz. Wenner-Gren Center International Symposium Series, vol. 32. Oxford: Pergamon Press, 1979, pp. 195–201.

    Google Scholar 

  150. Remmers J. E., C. R. Bainton, D. Ballantyne, J. P. Klein, and D. W. Richter. Reflex prolongation of stage I of expiration. Pflügers Arch. 407: 190–198, 1986.

    Article  PubMed  CAS  Google Scholar 

  151. Richter, D.W. Respiratory neural rhythmogenesis and afferent control. In: Human Physiology: From Cellular Mechanisms to Integration. Berlin: Springer Verlag, 1966 (in press).

    Google Scholar 

  152. Richter D.W. and D. Ballantyne. A three phase theory about the basic respiratory pattern generator. In: Central Neurone Environment and the Control Systems of Breathing and Circulation, edited by M.E. Schlaefke, H.P. Koepchen, and W.R. See. Berlin: Springer Verlag, 1983, pp. 164–174.

    Chapter  Google Scholar 

  153. Richter D. W., D. Ballantyne, and J. E. Remmers. The differential organization of medullary post-inspiratory activities. Pflügers Arch. 410: 420–427, 1987.

    Article  PubMed  CAS  Google Scholar 

  154. Richter D. W., K. Ballanyi, and S.W. Schwartzacher. Mechanisms of respiratory rhythm generation, Curr. Opin. Neurobiol. 2: 788–793, 1992.

    Article  CAS  Google Scholar 

  155. Richter D.W., H. Camerer, M. Meesman, and N. Röhrig. Studies on the synaptic interconnection between bulbar respiratory neurones of cats. Pflügers Arch. 380: 245257, 1979.

    Google Scholar 

  156. Richter D.W., J. Champagnat, and S. Mifftin. Membrane properties involved in respiratory rhythm generation. In: Neurobiology of the Control of Breathing. edited by C. von Euler and H. Lagercrantz. Karolinska Institute Nobel Conference Series. New York: Raven Press, 1986, pp. 141–147.

    Google Scholar 

  157. Richter D. W., F. Heyde, and M. Gabriel. Intracellular recordings from different types of medullary respiratory neurons of the cat. J. Neurophysiol. 38: 1162–1171, 1975.

    CAS  Google Scholar 

  158. St. John W. M. Characterization of the tidal volume regulating function of the pneumotaxic center. Respir. Physiol. 18: 64–79, 1973.

    Article  PubMed  Google Scholar 

  159. St. John W.M. Differing responses to hypercapnia and hypoxia following pneumotaxic center ablation. Respir. Physiol. 23: 1–9, 1975.

    Article  Google Scholar 

  160. St. John W.M., D. Bartlett Jr., K.V. Knuth, and J.-C. Wang. Brain stem genesis of automatic ventilatory patterns independent of spinal mechanisms. J. Appl. Physiol.: Respir. Environ. Exercise Physiol. 51: 204–210, 1981.

    Google Scholar 

  161. a.St. John W. M., Q. Hwang, E. E. Nattie, and D. Zhorn. Functions of the retrofacial nucleus in chemosensitivity and ventilatory neurogenesis. Respir. Physiol. 76: 159–172, 1989.

    Google Scholar 

  162. St. John W.M. and S.C. Wang. Alteration from apneusis to more regular rhythmic respiration in decerebrate cats. Respir. Physiol. 31: 91–106, 1977.

    Article  Google Scholar 

  163. Salmoiraghi G.C. and R. von Baumgarten. Intracellular potentials from respiratory neurones in brain-stem of cat and mechanism of rhythmic respiration. J. Neurophysiol. 24: 203–218, 1961.

    PubMed  CAS  Google Scholar 

  164. Salmoiraghi G.C. and B.D. Burns. Notes on mechanism of rhythmic respiration. J. Neurophysiol. 23: 14–26, 1960.

    PubMed  CAS  Google Scholar 

  165. Schlaefke M.E. Central chemosensitivity: a respiratory drive. Rev. Physiol. Biochem. Pharmacol. 909: 171–244, 1981.

    Article  Google Scholar 

  166. Sears T.A. The respiratory motoneurone: integration at spinal at spinal segmental level. In: Breathlessness, edited by J.B.L. Howell and E.J.M. Campbell. Oxford: Blackwell Scientific Publications, 1966, pp. 33–47.

    Google Scholar 

  167. Sears T.A. Breathing: a sensori motor act In The Scientific Basis of Medicine. Annual Reviews, edited by I. Gilliand and J. Francis. London: Athlone, 1971, pp. 129–147.

    Google Scholar 

  168. Segers L.S., S. Saporta, B.G. Lindsey, and R. Shannon. Functional associations among simultaneously monitored lateral medullary respiratory neurons in the cat. I. Evidence for excitatory and inhibitory actions of inspiratory neurons. J. Neurophysiol. 57: 1078 1100, 1987.

    Google Scholar 

  169. Sieck G.C., and R.M. Harper. Pneumotaxic area neuronal discharge during sleep-waking states in the cat. Exp. Neurol 67: 79–102, 1980.

    Article  PubMed  CAS  Google Scholar 

  170. Smith J.C. and J.L. Feldman. In vitro brainstem-spinal cord preparations for study of motor systems for mammalian respiration and locomotion. J. Neurosci. Meth. 21: 321–333, 1987.

    Article  CAS  Google Scholar 

  171. Smith J.C., H. Ellenberger, K. Ballanyi, D.W. Richter, and J.L. Feldman. Pre-Bötzinger complex: a brain stem region that may generate respiratory rhythm in mammals. Science 254: 726–729, 1991.

    Article  PubMed  CAS  Google Scholar 

  172. Smith J.C., J. Greer, G. Liu, and J.L. Feldman. Neural mechanisms generating respiratory pattern in mammalian brain stem-spinal coard in vitro. I. Spatiotemporal patterns of motor and medullary neuron activity. J. Neurophysiol. 64: 1149–1169, 1990.

    PubMed  CAS  Google Scholar 

  173. Speck D.F. Bötzinger complex region role in phrenic-to-phrenic inhibitory reflex of cat. J. Appl. Physiol. 67: 1364–1370, 1989.

    PubMed  CAS  Google Scholar 

  174. Speck D.F. and J.L. Feldman. The effect of microstimulation and microlesions in the dorsal and ventral respiratory groups in medulla of cat. J. Neurosci. 2: 744–757, 1982.

    PubMed  CAS  Google Scholar 

  175. Spyer K.M., D.S. McQueen, M.R. Dashwood, R.M. Sykes, M. de B. Daly, and J.R. Muddle. Localization of 125 I endothelin binding sites in the region of the carotid bifurcation and brain stem of the cat: possible baro-and chemoreceptor involvement. J. Cardiovas. Pharmacol. 17: S385 - S389. 1991.

    Article  CAS  Google Scholar 

  176. Srinivasan M., M. Goiny, T. Pantaleo, H. Lagercrantz, E. Brodin, M. Runold, and Y. Yamamoto. Enhanced in vivo release of substance P in the nucleus tactus solitarii during hypoxia in the rabbit: role of peripheral input. Brain Res. 546: 211–216, 1991.

    Article  PubMed  CAS  Google Scholar 

  177. Srinivasan M., G.R. Srinivasan, A.A. Mathé, and E. Theodorsson. Endothelin concentrations in the respiration-related structures of the medulla during the perinatal period of the rat. Dev. Brain Res. 74: 117–121, 1993.

    Article  CAS  Google Scholar 

  178. Srinivasan M., Y. Yamamoto, H. Lagercrantz, and H. Persson. Effect of a non peptide substance P antagonist on neonatal preprotachykinin-A gene expression in respiration-related structures of the brain stem. In: International Symposium on Substance P and Related Peptides. Regulatory Peptides, Suppl. 1, S149, 1992.

    Google Scholar 

  179. Srinivasan M., Y. Yamamoto, H. Persson, and H. Lagercrantz. Birth-related activation of preprotachykinin-A mRNA in the respiratory neural structures of the rabbit. Pediat. Res.: 29: 369–371, 1991.

    CAS  Google Scholar 

  180. Stella G. On the mechanism of production, and the physiological significance of “apneusis.” J. Physiol. (Lond.) 93: 10–23, 1938.

    CAS  Google Scholar 

  181. Stella G. The dependence of the activity of the “apneustic centre” on the carbon dioxide of the arterial blood. J. Physiol. (Lond.) 93: 263–275, 1938.

    CAS  Google Scholar 

  182. Strohl K.P., M.J. Hensley, M. Hallett, N.A. Saunders, and R.H. Ingram. Activation of upper airway muscles before onset of inspiration in normal humans. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 49: 638–642, 1980.

    CAS  Google Scholar 

  183. Tang P.C. Localization of the pneumotaxic center in the cat. Am. J. Physiol. 172: 645–652, 1953

    PubMed  CAS  Google Scholar 

  184. Tell F., A. Jean. Activation of N-methl-D aspartate receptors induces endogenous rhythmic bursting activities in nucleus tractur solitari neurons: An intracellular study on adult rat brain stem slices. Eur. J. Neurosci. 3: 1353–1365, 1991.

    Article  PubMed  Google Scholar 

  185. Vibert J. F., D. Caille, A.S. Foutz, A. Hugelin, and M. F. Villard. Does a multi-oscillator system control respiratory frequency independently of ventilation? In: Concepts and Formalizations in the Control of Breathing, edited by P. Baconnier, G. Benchetrit, and J. Demongeot. Manchester: Manchester University Press, 1987, pp. 377–388.

    Google Scholar 

  186. Wang S.C., S.H. Ngai, and M.J. Frumin. Organization of central respiratory mechanisms in the brain stem of the cat: genesis of normal respiratory rhythmicity. Am. J. Physiol. 190: 333–342, 1957.

    PubMed  CAS  Google Scholar 

  187. Ward D.G., A.M. Lefcourt, and D. S. Gann. Neurons in the dorsal rostral pons process information about changes in venous return and in arterial pressure. Brain Res. 181: 75–88, 1980.

    Article  PubMed  CAS  Google Scholar 

  188. Wiener, N. Cybernetics or control and communication in the Animal and the Machine, 2d ed. Cambridge, MA: The MIT Press, 1961.

    Google Scholar 

  189. Yamamoto Y. and H. Lagercrantz. Some effects of substance P on central respiratory control in rabbit pups. Acta Physiol. Scand. 124: 449–455, 1985.

    Article  PubMed  CAS  Google Scholar 

  190. Yamamoto Y., H. Onimaru, and I. Homma. Effect of substance P on respiratory rhythm and pre-inspiratory neurons in the ventrolateral structure of rostral medulla oblongata: an in vitro study. Brain Res. 599: 272–274, 1992.

    Article  PubMed  CAS  Google Scholar 

  191. Yamashiro S.M., J.A. Daubenspeck, F.S. Grodins, and T. N. Lauritsen. Total work rate of breathing optimization in CO, inhalation and exercise. J. Appl. Physiol. 38: 702–709, 1975.

    PubMed  CAS  Google Scholar 

  192. Yates F. E. Outline of physical theory of physiological systems. Can. J. Physiol. Pharmacol. 60: 1982, pp. 217–248.

    Article  PubMed  CAS  Google Scholar 

  193. Younes M. K., J.P. Baker, and J.E. Remmers. Characteristics of inspiratory inhibition by phasic volume feedback in cats. J. Appl. Physiol. 45: 80–86, 1978.

    PubMed  CAS  Google Scholar 

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von Euler, C. (1996). Rhythm Generation. In: West, J.B. (eds) Respiratory Physiology. People and Ideas. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7520-0_9

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