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Membrane Protein Structure: Lessons from Gramicidin

  • Chapter
Membrane Protein Structure

Part of the book series: Methods in Physiology Series ((METHPHYS))

Abstract

Gramicidin is an unusual membrane protein; it has a molecular weight of less than 2,000 daltons and contains D-amino acids, whereas most membrane proteins have molecular weights on the order of 100,000 daltons or more and contain L-amino acids exclusively. This small peptide, however, has the remarkable property of forming well-defined ion channels in lipid bilayer membranes. In fact, it is perhaps the best-characterized of all membrane ion channels. As a result of the many studies on gramicidin channels, a considerable amount of information on the structural and functional aspects of this molecule is available, and this information and the methods used to derive it are generally relevant to the study of other membrane protein structures.

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Authors
  1. G. Andrew Woolley
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  2. B. A. Wallace
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Editors and Affiliations

  1. College of Medicine, Department of Physiology and Biophysics, University of California, Irvine, Irvine, California, USA

    Stephen H. White Ph.D. (Professor of Physiology and Biophysics) (Professor of Physiology and Biophysics)

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© 1994 American Physiological Society

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Woolley, G.A., Wallace, B.A. (1994). Membrane Protein Structure: Lessons from Gramicidin. In: White, S.H. (eds) Membrane Protein Structure. Methods in Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7515-6_14

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  • DOI: https://doi.org/10.1007/978-1-4614-7515-6_14

  • Publisher Name: Springer, New York, NY

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