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Hypothetical Role of Endothelin in the Control of the Cardiovascular System

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Endothelin

Part of the book series: Clinical Physiology Series ((CLINPHY))

Abstract

The discovery that vascular endothelial cells can synthesize autocrine and paracrine substances that can alter the tone of the underlying smooth muscle and inhibit the aggregation of platelets revealed novel mechanisms that may contribute to cardiovascular homeostasis. This began with a series of studies that led to the discovery of prostacyclin41 and was followed by the demonstration that endothelial cells also form a nonprostanoid substance that was termed “endothelium-derived relaxing factor” (EDRF).21 Subsequent studies have shown that the major EDRF is nitric oxide or a labile nitroso compound20,27 formed from L-arginine in the endothelial ce11.42

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Authors
  1. Gabor M. Rubanyi
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  2. John T. Shepherd
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Editors and Affiliations

  1. Institute of Pharmacology, Research Center, Schering AG, Berlin, Germany

    Gabor M. Rubanyi M.D., Ph.D.

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© 1992 American Physiological Society

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Rubanyi, G.M., Shepherd, J.T. (1992). Hypothetical Role of Endothelin in the Control of the Cardiovascular System. In: Rubanyi, G.M. (eds) Endothelin. Clinical Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7514-9_16

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  • DOI: https://doi.org/10.1007/978-1-4614-7514-9_16

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7514-9

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