Endothelin pp 221-237 | Cite as

Endothelin in Human Disease. II: Shock, Pulmonary Hypertension, and Congestive Heart Failure

  • Duncan J. Stewart
Part of the Clinical Physiology Series book series (CLINPHY)


Since the identification of endothelin by Yanagisawa and coworkers less than four years ago, there has been considerable interest in defining the molecular biology of endothelin production and its biological properties. It is perhaps indicative of the times that our understanding of the physiological role of endothelin has lagged considerably behind our knowledge of its molecular biology.29 Although described in detail in accompanying chapters, some crucial aspects of endothelin’s biological activity relating to its possible physiological and pathophysiological importance are briefly reviewed here. Unless otherwise specified, the endothelin referred to in this chapter is endothelin-1, the principal endothelin product of vascular endothelium. When appropriate, endothelin-2 and endothelin-3 will be specified.


Pulmonary Hypertension Atrial Natriuretic Peptide Cardiogenic Shock Heart Circ Vasoconstrictor Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© American Physiological Society 1992

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  • Duncan J. Stewart

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