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Physiology of Inflammation pp 473–495Cite as

Mast Cells in Inflammation

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Part of the book series: Methods in Physiology Series ((METHPHYS))

Abstract

Mammals have developed effective innate response mechanisms to rapidly identify and eliminate potentially harmful foreign particles or organisms. To be effective, these responses need a system to detect pathogens in the tissues, and a mechanism to destroy these foreign bodies. A deficiency in either detection or elimination of foreign particles leads to a compromised host. However, excessive or inappropriate activation of either aspect of the inflammatory response can also lead to debilitating or even fatal diseases. The mast cell is one detection system found in most tissues that can cause the effector phase of the inflammatory response to rapidly mobilize leukocytes from the vasculature to affected tissues. In this chapter, we will highlight evidence that mast cells can initiate the leukocyte recruitment cascade in response to allergens, infectious agents, oxidative stress, and other inflammatory mediators. Unexplored and controversial areas will also be highlighted.

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Authors
  1. Brent Johnston
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  2. Paul Kubes
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Editors and Affiliations

  1. Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, Virginia, USA

    Klaus Ley M.D.

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© 2001 American Physiological Society

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Johnston, B., Kubes, P. (2001). Mast Cells in Inflammation. In: Ley, K. (eds) Physiology of Inflammation. Methods in Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7512-5_23

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  • DOI: https://doi.org/10.1007/978-1-4614-7512-5_23

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7512-5

  • eBook Packages: Springer Book Archive

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