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Knockout Mice in Inflammation Research

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Physiology of Inflammation

Part of the book series: Methods in Physiology Series ((METHPHYS))

Abstract

The study of mutations has tremendously aided the identification of genes and their functions in many different experimental organisms. In the past, researchers working in mammalian systems relied on naturally occurring mutations or those induced by chemicals or radiation to study the different biological roles of a gene. These efforts were tremendously aided by the development of strategies during the 1980s that allowed the generation of mice carrying specific gene mutations (Capecchi, 1989; Joyner, 1993). This technique was referred to as gene targeting and has been widely used to study the functions of many different mammalian genes in physiologic processes. More recently, gene targeting has been applied to genes that mediate inflammation.

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Authors
  1. Daniel C. Bullard
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Editors and Affiliations

  1. Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, Virginia, USA

    Klaus Ley M.D.

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© 2001 American Physiological Society

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Bullard, D.C. (2001). Knockout Mice in Inflammation Research. In: Ley, K. (eds) Physiology of Inflammation. Methods in Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7512-5_18

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  • DOI: https://doi.org/10.1007/978-1-4614-7512-5_18

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