Lipid Lifesaver

Local anesthetic, lipid emulsion

Abstract

This case discusses the interesting but not fully understood pharmacodynamic interaction between local anesthetics and lipid emulsion.

Keywords

Bupivacaine Local anesthetic Toxicity Lipid Emulsion Local anesthetic systemic toxicity LAST 

References

  1. 1.
    Bern S, Akpa BS, Kuo I, et al. Lipid resuscitation: a life-saving antidote for local anesthetic toxicity. Curr Pharm Biotechnol. 2011;12(2):313–9.PubMedCrossRefGoogle Scholar
  2. 2.
    Rahman S, Li J, Bopassa JC, et al. Phosphorylation of GSK-3β mediates intralipid-induced cardioprotection against ischemia/reperfusion injury. Anesthesiology. 2011;115(2):242–53.PubMedPubMedCentralCrossRefGoogle Scholar
  3. 3.
    Neal JM, Bernards CM, Butterworth JF, et al. Practice advisory on local anesthetic systemic toxicity. Reg Anesth Pain Med. 2010;35(2):152–61.PubMedCrossRefGoogle Scholar
  4. 4.
    Hiller DB, Gregorio GD, Ripper R, et al. Epinephrine impairs lipid resuscitation from bupivacaine overdose: a threshold effect. Anesthesiology. 2009;111(3):498–505.PubMedCrossRefGoogle Scholar
  5. 5.
    Smith NA. Possible side effects of Intralipid rescue therapy. Anaesthesia. 2010;65(2):210–1.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of AnesthesiologyUniversity of IllinoisChicagoUSA

Personalised recommendations