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Are Drug-Drug Interactions The Smoking Guns of Local Anesthetic Toxicity? Smoking Gun II

Bupivacaine, methocarbamol

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A Case Approach to Perioperative Drug-Drug Interactions

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Abstract

This case discusses a possible synergistic pharmacodynamic interaction between bupivacaine and methocarbamol, leading to CNS depression and change in mental status.

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References

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Author information

Authors and Affiliations

  1. Department of Anesthesiology & Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    L. Michele Noles MD

Authors
  1. L. Michele Noles MD
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Corresponding author

Correspondence to L. Michele Noles MD .

Editor information

Editors and Affiliations

  1. Anesthesia Services Department, Philadelphia Veterans Affairs Med Center, Philadelphia, PA, USA

    Catherine Marcucci MD

  2. Department of Anesthesiology, Oregon Health and Science University, Portland, OR, USA

    Michael P. Hutchens MD

  3. Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA

    Erica D. Wittwer MD, PhD , Toby N. Weingarten MD , Juraj Sprung MD, PhD  & Wayne T. Nicholson MD, PharmD, MSc , ,  & 

  4. Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Kirk Lalwani MD

  5. Department of Anesthesiology, University of Pittsburgh School of Med Liliane S. Kaufmann Building, Pittsburgh, PA, USA

    David G. Metro MD

  6. Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, USA

    Randal O. Dull MD, PhD

  7. Department of Anesthesiology, Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Christopher E. Swide MD

  8. Department of Learning Health Sciences, University of Michigan Medical School, Ann Arbor, MI, USA

    F. Jacob Seagull PhD

  9. Department of Anesthesiology and Perioperative Medicine, Portland, OR, USA

    Jeffrey R. Kirsch MD (Professor and Chair) (Professor and Chair)

  10. Department of Psychiatry, University of Maryland Medical System VA Maryland Health Care System, Baltimore, MD, USA

    Neil B. Sandson MD

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Noles, L.M. (2015). Are Drug-Drug Interactions The Smoking Guns of Local Anesthetic Toxicity? Smoking Gun II. In: Marcucci, C., et al. A Case Approach to Perioperative Drug-Drug Interactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7495-1_42

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  • DOI: https://doi.org/10.1007/978-1-4614-7495-1_42

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7494-4

  • Online ISBN: 978-1-4614-7495-1

  • eBook Packages: MedicineMedicine (R0)

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