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Magnesium Mama and the Mad Dad

Magnesium sulfate, propofol, remifentanil, vecuronium

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A Case Approach to Perioperative Drug-Drug Interactions

Abstract

This case discusses pharmacodynamic drug–drug interactions between magnesium sulfate and intravenous anesthetics and between magnesium sulfate and vecuronium. Additional information regarding the use of magnesium for perioperative patients is presented.

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References

  1. James MF. Magnesium: an emerging drug in anaesthesia. Br J Anaesth. 2009;103:465–7.

    Article  PubMed  CAS  Google Scholar 

  2. Greene MF. Magnesium sulfate for preeclampsia. N Engl J Med. 2003;348:275–6.

    Article  PubMed  Google Scholar 

  3. Soave PM, Conti G, Costa R, et al. Magnesium and anaesthesia. Curr Drug Targets. 2009;10:734–43.

    Article  PubMed  CAS  Google Scholar 

  4. Magpie Trial Collaborative Group. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. Lancet. 2002;359:1877–90.

    Article  Google Scholar 

  5. Fawcett WJ, Haxby EJ, Male DA. Magnesium: physiology and pharmacology. Br J Anaesth. 1999;83:302–20.

    Article  PubMed  CAS  Google Scholar 

  6. Lysakowski C, Dumont L, Czarnetzki C, et al. Magnesium as an adjuvant to postoperative analgesia: a systematic review of randomized trials. Anesth Analg. 2007;104:1532–9.

    Article  PubMed  CAS  Google Scholar 

  7. Czarnetzki C, Lysakowski C, Elia N, et al. Time course of rocuronium-induced neuromuscular block after pre-treatment with magnesium sulphate: a randomised study. Acta Anaesthesiol Scand. 2009;11:1–8.

    Google Scholar 

  8. Kussman B, Shorten G, Uppington J, et al. Administration of magnesium sulphate before rocuronium: effects on speed of onset and duration of neuromuscular block. Br J Anaesth. 1997;79(1):122–4.

    Article  PubMed  CAS  Google Scholar 

  9. James MF, Schenk PA, Van der Veen BW. Priming of pancuronium with magnesium. Br J Anaesth. 1991;66:247–9.

    Article  PubMed  CAS  Google Scholar 

  10. Lampl E, Dandoy M. Priming of atracurium with magnesium. Br J Anaesth. 1993;70:A139.

    Google Scholar 

  11. Fuchs-Buder T, Wilder-Smith OH, Borgeat A, et al. Interaction of magnesium sulphate with vecuronium induced neuromuscular block. Br J Anaesth. 1995;74:405–9.

    Article  PubMed  CAS  Google Scholar 

  12. Na HS, Lee JH, Hwang JY, et al. Effects of magnesium sulphate on intraoperative neuromuscular blocking agent requirements and postoperative analgesia in children with cerebral palsy. Br J Anaesth. 2010;104:344–50.

    Article  PubMed  CAS  Google Scholar 

  13. Gupta K, Vohra V, Sood J. The role of magnesium as an adjuvant during general anesthesia. Anaesthesia. 2006;61:1058–63.

    Article  PubMed  CAS  Google Scholar 

  14. Schultz-Stubner S, Wettmann G, Reyle-Hahn SM, et al. Magnesium as part of balanced general anesthesia with propofol, remifentanil, and mivacurium: a double-blind, randomized prospective study in 50 patients. Eur J Anaesthesiol. 2001;18(11):723–9.

    Article  Google Scholar 

  15. Telci L, Esen F, Akcora D, et al. Evaluation of effects of magnesium sulphate in reducing intraoperative anaesthetic requirements. Br J Anaesth. 2002;89:594.

    Article  PubMed  CAS  Google Scholar 

  16. Khafagy HF, Osman ES, Naguib AF. Effects of different dose regimens of magnesium on pharmacodynamics and anesthetic requirements of balanced general anesthesia. J Egypt Soc Parasitol. 2007;37(2):469–82.

    PubMed  Google Scholar 

  17. Dabbagh A, Elyasi H, Razavi SS, et al. Intravenous magnesium sulfate for post-operative pain in patients undergoing lower limb orthopedic surgery. Acta Anaesthesiol Scand. 2009;53(8):1088–91.

    Article  PubMed  CAS  Google Scholar 

  18. Lysakowki C, Dumont L, Czarnetzki C, et al. Magnesium as an adjuvant to postoperative analgesia: a systematic review of randomized trials. Anesth Analg. 2007;104(6):1532–9.

    Article  Google Scholar 

  19. Lee DH, Kwon IC. Magnesium sulphate has beneficial effects as an adjuvant during general anaesthesia for Caesarean section. Br J Anaesth. 2009;103(6):861–6.

    Article  PubMed  CAS  Google Scholar 

  20. Altan A, Turgut N, Yildiz F, et al. Effects of magnesium sulphate and clonidine on propofol consumption, haemodynamics and postoperative recovery. Br J Anaesth. 2005;94:438–41.

    Article  PubMed  CAS  Google Scholar 

  21. Mayer ML, Westbrook GL, Guthrie PB. Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurons. Nature. 1984;309:261–3.

    Article  PubMed  CAS  Google Scholar 

  22. Woolf CJ, Thompson SW. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartatic acid receptor activation: implications for treatment of post-injury pain hypersensitivity states. Pain. 1991;44:293–9.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Ana Maria Manrique MD .

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Manrique, A.M., Marcucci, C., Subramaniam, K. (2015). Magnesium Mama and the Mad Dad. In: Marcucci, C., et al. A Case Approach to Perioperative Drug-Drug Interactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7495-1_34

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  • DOI: https://doi.org/10.1007/978-1-4614-7495-1_34

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7494-4

  • Online ISBN: 978-1-4614-7495-1

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