Skip to main content
SpringerLink
Log in
Book cover

A Case Approach to Perioperative Drug-Drug Interactions pp 15–22Cite as

Pharmacokinetic Interactions: Core Concepts

  • Chapter

Abstract

This chapter discusses the essential terms and concepts pertaining to how the body processes drugs. This subset of pharmacology is known as pharmacokinetics.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Kiani J, Imam SZ. Medicinal importance of grapefruit juice and its interaction with various drugs. Nutr J. 2007;6:33.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Kupferschmidt HH, Ha HR, Ziegler WH, et al. Interaction between grapefruit juice and midazolam in humans. Clin Pharmacol Ther. 1995;58:20–8.

    Article  PubMed  CAS  Google Scholar 

  3. Product Information: COUMADIN(R) oral tablets, intravenous injection, warfarin sodium oral tablets, intravenous injection. Princeton: Bristol-Myers Squibb Company; 2007.

    Google Scholar 

  4. Maron BA, Rocco TP. Pharmacotherapy of congestive heart failure. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 12th ed. New York: McGraw-Hill Medical; 2011.

    Google Scholar 

  5. Tatro DS. Drug Interaction Facts: The Authority on Drug Interactions. Wolters Kluwer Health: St. Louis, MO; 2007.

    Google Scholar 

  6. Badyal DK, Dadhich AP. Cytochrome P450 and drug interactions. Indian J Pharmacol. 2001;33:248–59.

    CAS  Google Scholar 

  7. Leucuta SE, Vlase L. Pharmacokinetics and metabolic drug interactions. Curr Clin Pharmacol. 2006;1:5–20.

    Article  PubMed  CAS  Google Scholar 

  8. Williams JA, Ring BJ, Cantrell VE, et al. Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug Metab Dispos. 2002;30:883–91.

    Article  PubMed  CAS  Google Scholar 

  9. Granfors MT, Wang JS, Kajosaari LI, et al. Differential inhibition of cytochrome P450 3A4, 3A5 and 3A7 by five human immunodeficiency virus (HIV) protease inhibitors in vitro. Basic Clin Pharmacol Toxicol. 2006;98:79–85.

    Article  PubMed  CAS  Google Scholar 

  10. May T, Rambeck B. Serum concentrations of valproic acid: influence of dose and comedication. Ther Drug Monit. 1985;7:387–90.

    Article  PubMed  CAS  Google Scholar 

  11. Perucca E. Clinically relevant drug interactions with antiepileptic drugs. Br J Clin Pharmacol. 2006;61:246–55.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  12. Sideras K, Ingle JN, Ames MM, et al. Coprescription of tamoxifen and medications that inhibit CYP2D6. J Clin Oncol. 2010;28:2768–76.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA

    Erica D. Wittwer MD, PhD & Wayne T. Nicholson MD, PharmD, MSc

Authors
  1. Erica D. Wittwer MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wayne T. Nicholson MD, PharmD, MSc
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Erica D. Wittwer MD, PhD .

Editor information

Editors and Affiliations

  1. Anesthesia Services Department, Philadelphia Veterans Affairs Med Center, Philadelphia, PA, USA

    Catherine Marcucci MD

  2. Department of Anesthesiology, Oregon Health and Science University, Portland, OR, USA

    Michael P. Hutchens MD

  3. Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA

    Erica D. Wittwer MD, PhD , Toby N. Weingarten MD , Juraj Sprung MD, PhD  & Wayne T. Nicholson MD, PharmD, MSc , ,  & 

  4. Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Kirk Lalwani MD

  5. Department of Anesthesiology, University of Pittsburgh School of Med Liliane S. Kaufmann Building, Pittsburgh, PA, USA

    David G. Metro MD

  6. Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, USA

    Randal O. Dull MD, PhD

  7. Department of Anesthesiology, Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Christopher E. Swide MD

  8. Department of Learning Health Sciences, University of Michigan Medical School, Ann Arbor, MI, USA

    F. Jacob Seagull PhD

  9. Department of Anesthesiology and Perioperative Medicine, Portland, OR, USA

    Jeffrey R. Kirsch MD (Professor and Chair) (Professor and Chair)

  10. Department of Psychiatry, University of Maryland Medical System VA Maryland Health Care System, Baltimore, MD, USA

    Neil B. Sandson MD

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media New York

About this chapter

Cite this chapter

Wittwer, E.D., Nicholson, W.T. (2015). Pharmacokinetic Interactions: Core Concepts. In: Marcucci, C., et al. A Case Approach to Perioperative Drug-Drug Interactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7495-1_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-7495-1_3

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7494-4

  • Online ISBN: 978-1-4614-7495-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation