Delicious but Malicious

Licorice, spironolactone, hypokalemia
  • Eric Fox
  • Kirk Lalwani


This case discusses the synergistic pharmacodynamic interaction between the mineralocorticoid activity of licorice, and the diuretic effects of hydrochlorothiazide, each contributing to the development of hypokalemia.


Synergism Synergistic Pharmacodynamics Licorice Hydrochlorothiazide Diuretic Diuresis Hypokalemia Nephron 


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.College of MedicineOregon Health and Science UniversityPortlandUSA
  2. 2.Department of Anesthesiology & Perioperative MedicineOregon Health and Science UniversityPortlandUSA

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