The Topic of the Day

Fatal Forty DDI: cimetidine, lidocaine, CYP1A2, CYP3A4
  • Catherine Marcucci


This case discusses two pharmacokinetic interactions between lidocaine and cimetidine (metabolic and distribution) resulting in lidocaine toxicity.


Pharmacokinetic Metabolism Distribution Lidocaine Cimetidine CYP Cytochrome P450 1A2 3A4 2C9 2C19 2D6 2E19 CYP1A2 CYP3A4 Inhibition Paninhibition CYP2C9 CYP2C19 CYP2D6 CYP2E19 H2 receptor H2 receptor antagonism Topical anesthesia Awake intubation Toxicity Seizure 


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Anesthesia Services DepartmentPhiladelphia Veterans Affairs Medical CenterPhiladelphiaUSA

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