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The Cytochrome P450 System in Disease States—A Brief Review

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Book cover A Case Approach to Perioperative Drug-Drug Interactions

Abstract

This chapter briefly discusses the cytochrome P450 system in several disease states, including heart, liver, and kidney failure.

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References

  1. Kirwan CJ, Lee T, Holt DW, et al. Using midazolam to monitor changes in hepatic drug metabolism in critically ill patients. Intensive Care Med. 2009;35(7):1271–5. Epub 2009 Feb 7.

    Article  PubMed  CAS  Google Scholar 

  2. Kirwan CJ, MacPhee IA, Lee T, et al. Acute kidney injury reduces the hepatic metabolism of midazolam in critically ill patients. Intensive Care Med. 2012;38(1):76–84. Epub 2011 Oct 18.

    Article  PubMed  CAS  Google Scholar 

  3. Zordoky BN, El-Kadi AO. Modulation of cardiac and hepatic cytochrome P450 enzymes during heart failure. Curr Drug Metab. 2008;9(2):122–8.

    Article  PubMed  CAS  Google Scholar 

  4. Adedoyin A, Arns PA, Richards WO, et al. Selective effect of liver disease on the activities of specific metabolizing enzymes: investigation of cytochromes P450 2C19 and 2D6. Clin Pharmacol Ther. 1998;64(1):8–17.

    Article  PubMed  CAS  Google Scholar 

  5. Frye RF, Zgheib NK, Matzke GR, et al. Liver disease selectively modulates cytochrome P450–mediated metabolism. Clin Pharmacol Ther. 2006;80(3):235–45.

    Article  PubMed  CAS  Google Scholar 

  6. Chiu KW, Nakano T, Hu TH, et al. Influence of CYP2C19 genotypes on graft pathological findings and postoperative liver function in recipients after living-donor liver transplantation. Ann Transplant. 2010;15(4):38–43.

    PubMed  CAS  Google Scholar 

  7. Chiu KW, Nakano T, Tseng HP, et al. Western blotting analysis for quantitative detection of CYP2C19 expression in liver tissues in the setting of living donor liver transplantation. Hepatogastroenterology. 2012;59(115):805–8.

    PubMed  CAS  Google Scholar 

  8. McCance-Katz EF. Drug interactions associated with methadone, buprenorphine, cocaine, and HIV medications: implications for pregnant women. Life Sci. 2011;88(21–22):953–8.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  9. Madadi P, Avard D, Koren G. Pharmacogenetics of opioids for the treatment of acute maternal pain during pregnancy and lactation. Curr Drug Metab. 2012;13(6):721–7.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Anesthesia Services Department, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA

    Catherine Marcucci MD

Authors
  1. Catherine Marcucci MD
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Corresponding author

Correspondence to Catherine Marcucci MD .

Editor information

Editors and Affiliations

  1. Anesthesia Services Department, Philadelphia Veterans Affairs Med Center, Philadelphia, PA, USA

    Catherine Marcucci MD

  2. Department of Anesthesiology, Oregon Health and Science University, Portland, OR, USA

    Michael P. Hutchens MD

  3. Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA

    Erica D. Wittwer MD, PhD , Toby N. Weingarten MD , Juraj Sprung MD, PhD  & Wayne T. Nicholson MD, PharmD, MSc , ,  & 

  4. Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Kirk Lalwani MD

  5. Department of Anesthesiology, University of Pittsburgh School of Med Liliane S. Kaufmann Building, Pittsburgh, PA, USA

    David G. Metro MD

  6. Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, USA

    Randal O. Dull MD, PhD

  7. Department of Anesthesiology, Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Christopher E. Swide MD

  8. Department of Learning Health Sciences, University of Michigan Medical School, Ann Arbor, MI, USA

    F. Jacob Seagull PhD

  9. Department of Anesthesiology and Perioperative Medicine, Portland, OR, USA

    Jeffrey R. Kirsch MD (Professor and Chair) (Professor and Chair)

  10. Department of Psychiatry, University of Maryland Medical System VA Maryland Health Care System, Baltimore, MD, USA

    Neil B. Sandson MD

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Marcucci, C. (2015). The Cytochrome P450 System in Disease States—A Brief Review. In: Marcucci, C., et al. A Case Approach to Perioperative Drug-Drug Interactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7495-1_13

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  • DOI: https://doi.org/10.1007/978-1-4614-7495-1_13

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7494-4

  • Online ISBN: 978-1-4614-7495-1

  • eBook Packages: MedicineMedicine (R0)

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