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Primary Cutaneous Lymphomas

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Skin Cancer

Part of the book series: Current Clinical Pathology ((CCPATH))

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Abstract

Primary cutaneous lymphomas (PCL) represent a heterogeneous group of skin neoplasms, which sometimes can pose difficulties in their diagnosis and in the differential diagnosis with benign lymphoid proliferations.

This chapter analyses the main problems in evaluating lymphoid infiltrates of the skin, with particular attention to the distinction between benign and malignant proliferation, and addresses the most frequent diagnostic challenges in everyday practice. Moreover, the advantages and disadvantages of the available diagnostic tools have been detailed, with particular reference to the immunohistochemistry and molecular pathology techniques.

Finally, the most common entities between T-cell and B-cell lymphoid neoplasms primary of the skin have been described in detail, according to the updated classification schemes.

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Author information

Authors and Affiliations

  1. Pathology Unit, Hospital A. Manzoni, Via dell’Eremo 9/12, Lecco, 23900, Italy

    Emanuela Bonoldi

  2. Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

    Umberto Gianelli

Authors
  1. Emanuela Bonoldi
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  2. Umberto Gianelli
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Corresponding author

Correspondence to Emanuela Bonoldi .

Editor information

Editors and Affiliations

  1. and Pharmaceutical Sciences and Technologies, Second University of Naples Department of Environmental, Biological, Naples, Italy

    Alfonso Baldi

  2. Department of Dermatology, Pius Hospital de Valls, Valls, Tarragona, Spain

    Paola Pasquali

  3. S.A.F.U. Department, Regina Elena Cancer Institute, Rome, Italy

    Enrico P Spugnini

Glossary

Epidermotropism

Tendency to infiltrate the epidermis

Extranodal

A localisation of lymphoproliferative neoplasms different from a lymph node

Grenz zone

An area savings the epidermis

Mono(poly)clonality

Belonging to a single (or multiple) cell clone(s)

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Bonoldi, E., Gianelli, U. (2014). Primary Cutaneous Lymphomas. In: Baldi, A., Pasquali, P., Spugnini, E. (eds) Skin Cancer. Current Clinical Pathology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-7357-2_9

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  • DOI: https://doi.org/10.1007/978-1-4614-7357-2_9

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4614-7356-5

  • Online ISBN: 978-1-4614-7357-2

  • eBook Packages: MedicineMedicine (R0)

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