Skin Cancer pp 89-108 | Cite as

Skin Adnexal Tumours: A Large Spectrum of Clinic-Pathological Lesions

  • Renato Franco
  • Maria Elena Errico
  • Federica Zito Marino
  • Anna Maria Anniciello
  • Gerardo Botti
  • Michele Caraglia
  • Anna Grimaldi
Chapter
Part of the Current Clinical Pathology book series (CCPATH)

Abstract

Skin adnexal neoplasms comprise a wide spectrum of more than 80 benign and malignant tumours, exhibiting morphological differentiation towards pilosebaceous unit, eccrine and apocrine glands. In addition more than one line of differentiation in this neoplasm could be observed. These tumours generally exhibit a benign behaviour, but malignant histotypes also exist. Clinical diagnosis of specific entity and of their potential malignancy is quite impossible. Thus, the diagnosis always requires surgical excision of skin lesion, and histological features at haematoxylin and eosin-stained sections are considered generally adequate for the correct classification of skin adnexal tumours. The use of histochemical and immunohistochemical stains could further aid in this purpose. Finally, they are usually encountered as single, sporadic tumours, but they may also occasionally be multiple and hereditary, heralding complex genetic syndromes that comprise visceral cancers.

Keywords

Adenoma Ghost Astrocytoma Rapamycin Celecoxib 

Notes

Glossary

APC

Adenomatous polyposis coli

BCC

Basal-cell carcinoma

BHDS

Birt–Hogg–Dube’ syndrome

CAT

Cutaneous appendage tumors

CHRPE

Congenital hypertrophy of the retinal pigment epithelium

CS

Cowden syndrome

CSG

Cutaneous sweat gland

CSGT

Cutaneous sweat gland tumours

FAP

Familial adenomatous polyposis

FLCN

Folliculin

GS

Gardner syndrome

H&E

Haematoxylin and eosin

MFT

Multiple familial tricoepithelioma

MLG

Mammary-like glands

MTS

Muir–Torre syndrome

NSJ

Nevus sebaceous of Jadassohn

PTC

Proliferating trichilemmal cyst

PTEN

Phosphatase and TENsin

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Renato Franco
    • 1
  • Maria Elena Errico
    • 2
  • Federica Zito Marino
    • 1
  • Anna Maria Anniciello
    • 1
  • Gerardo Botti
    • 1
  • Michele Caraglia
    • 3
  • Anna Grimaldi
    • 3
  1. 1.Pathology UnitNational Institute of Tumours Fondazione “G. Pascale”NaplesItaly
  2. 2.Pathology UnitPaediatric Hospital Santobono-PausiliponNaplesItaly
  3. 3.Department of Biochemistry and BiophysicsSecond University of NaplesNaplesItaly

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