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Skin Cancer pp 529-545 | Cite as

Gene Expression Profiling in Melanoma

Chapter
Part of the Current Clinical Pathology book series (CCPATH)

Abstract

One of the big challenges in cancer research is to identify genomic alterations responsible for genesis and progression of disease. Melanoma is one of the most difficult tumours to treat for its aggressiveness, strong therapeutic resistance and proclivity for late metastasis. Here we describe the new gene high-throughput technologies, microarray and next-generation sequencing (NGS), and their impact in melanoma research. We illustrate their use from the discovery of melanoma biomarkers and therapeutic targets to clinical applications including patients’ classification and stratification.

Keywords

Primary Melanoma Vasculogenic Mimicry Primary Cutaneous Melanoma Thin Melanoma Superficial Spreading Melanoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgement

We are grateful to Anna Maria Aliperti for her assistance in the editing of the manuscript.

Glossary

ALM

Acral lentiginous melanoma, a melanoma subtype not associated with UV exposure

Cye3 and Cy5

Fluorescent dyes belonging to the cyanine dye family

Gbp

Giga base pairs, one billion pairs of DNA nucleotide bases

GWA

Genome-wide association

LMM

Lentigo maligna melanoma, a melanoma subtype associated with chronic sun exposure

MM

Metastatic melanoma

NGS

Next-generation sequencing

NHEM

Normal human epidermal melanocytes

PCM

Primary cutaneous melanoma

RGP

Radial growth phase melanoma

SSM

Superficial spreading melanoma, a melanoma subtype linked to severe sunburns

TMA

Tissue microarray

VGP

Vertical growth phase melanoma

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Institute of Genetics and Biophysics, I.G.B., A.Buzzati-Traverso, CNRNaplesItaly
  2. 2.Department of Genetics and BiophysicsInstitute of Genetics and BiophysicsNaplesItaly

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