Advertisement

Skin Cancer pp 419-424 | Cite as

Lasers for Skin Cancer

  • Michael P. McLeod
  • Katherine M. Ferris
  • Sonal Choudhary
  • Yasser A. Alqubaisy
  • Keyvan Nouri
Chapter
Part of the Current Clinical Pathology book series (CCPATH)

Abstract

The optimal laser treatment for skin cancer has not yet been developed. The first lasers that were used in an attempt to treat skin cancer emitted a continuous wave; however, significant nonspecific thermal heating occurred. In order to not extend beyond the thermal relaxation time of targeted tissue, pulsed lasers were developed. These lasers are now showing promise for treating skin cancer, specifically basal cell carcinoma. Recent studies by Shah et al. followed by Konnikov et al. have demonstrated that the 595 nm pulse dye laser may be effective for basal cell carcinomas of approximately 1.5 cm or less in diameter. Other approaches combining the Er:YAG and CO2 ablative lasers as adjunctive agents to photodynamic therapy are also showing promise for the treatment of basal cell carcinomas.

Keywords

Basal Cell Carcinoma Actinic Keratose Reflectance Confocal Microscopy Yttrium Aluminum Garnet Laser Mohs Micrographic Surgery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Glossary

CW

Continuous wave

Er:YAG

Erbium-doped yttrium aluminum garnet

Nd-YAG

Neodymium-doped yttrium aluminum garnet

References

  1. 1.
    Wheeland RG, Bailin PL, Ratz JL, et al. Carbon dioxide laser vaporization and curettage in the treatment of large or multiple superficial basal cell carcinomas. J Dermatol Surg Oncol. 1987;13:119–25.PubMedCrossRefGoogle Scholar
  2. 2.
    Olbricht SM, Stern RS, Tang SV, et al. Complications of cutaneous laser surgery. A survey. Arch Dermatol. 1987;123:345–9.PubMedCrossRefGoogle Scholar
  3. 3.
    Kauvar AN, Waldorf HA, Geronemus RG. A histopathological comparison of “char-free” carbon dioxide lasers. Dermatol Surg. 1996;22:343–8.PubMedGoogle Scholar
  4. 4.
    Trelles MA, David LM, Rigau J. Penetration depth of ultrapulse carbon dioxide laser in human skin. Dermatol Surg. 1996;22:863–5.PubMedGoogle Scholar
  5. 5.
    Cotton J, Hood AF, Gonin R, et al. Histologic evaluation of preauricular and postauricular human skin after high-energy, short-pulse carbon dioxide laser. Arch Dermatol. 1996;132:425–8.PubMedCrossRefGoogle Scholar
  6. 6.
    Tanzi EL, Lupton JR, Alster TS. Lasers in dermatology: four decades of progress. J Am Acad Dermatol. 2003;49:1–31; quiz 31−4.PubMedCrossRefGoogle Scholar
  7. 7.
    Wheeland RG, Bailin PL, Norris MJ. Argon laser photocoagulative therapy of Kaposi’s sarcoma: a clinical and histologic evaluation. J Dermatol Surg Oncol. 1985;11:1180–5.PubMedCrossRefGoogle Scholar
  8. 8.
    Landthaler M, Haina D, Brunner R, et al. Laser therapy of bowenoid papulosis and Bowen’s disease. J Dermatol Surg Oncol. 1986;12:1253–7.PubMedGoogle Scholar
  9. 9.
    Arndt KA. New pigmented macule appearing 4 years after argon laser treatment of lentigo maligna. J Am Acad Dermatol. 1986;14:1092.PubMedCrossRefGoogle Scholar
  10. 10.
    Arndt KA. Argon laser treatment of lentigo maligna. J Am Acad Dermatol. 1984;10:953–7.PubMedCrossRefGoogle Scholar
  11. 11.
    Goldman L. Surgery by laser for malignant melanoma. J Dermatol Surg Oncol. 1979;5:141–4.PubMedGoogle Scholar
  12. 12.
    Goldman L, Schwartz RA. Current development for laser surgery for skin cancer. In: Schwartz RA, editor. Skin cancer- recognition and management. New York: Spring; 1988. p. 346.CrossRefGoogle Scholar
  13. 13.
    Geronemus R, Ashinoff R. Lasers in the treatment of skin cancer. Dermatol Clin. 1991;9:765–76.PubMedGoogle Scholar
  14. 14.
    Stein BS. Laser treatment of condylomata acuminata. J Urol. 1986;136:593–4.PubMedGoogle Scholar
  15. 15.
    Achauer BM, Vander Kam VM. Capillary hemangioma (strawberry mark) of infancy: comparison of argon and Nd:YAG laser treatment. Plast Reconstr Surg. 1989;84:60–9; discussion 70.PubMedCrossRefGoogle Scholar
  16. 16.
    Brunner R, Landthaler M, Haina D, et al. Treatment of benign, semimalignant, and malignant skin tumors with the Nd:YAG laser. Lasers Surg Med. 1985;5:105–10.PubMedCrossRefGoogle Scholar
  17. 17.
    Landthaler M, Haina D, Brunner R, et al. Neodymium-YAG laser therapy for vascular lesions. J Am Acad Dermatol. 1986;14:107–17.PubMedCrossRefGoogle Scholar
  18. 18.
    Wishnow KI, Johnson DE. Effective outpatient treatment of Kaposi’s sarcoma of the urethral meatus using the neodymium:YAG laser. Lasers Surg Med. 1988;8:428–32.PubMedCrossRefGoogle Scholar
  19. 19.
    Keller GS, Doiron DR, Fisher GU. Photodynamic therapy in otolaryngology – head and neck surgery. Arch Otolaryngol. 1985;111:758–61.PubMedCrossRefGoogle Scholar
  20. 20.
    Wagner RI, Kozlov AP, Moskalik KG. Laser radiation therapy of skin melanoma. Strahlentherapie. 1981;157:670–2.PubMedGoogle Scholar
  21. 21.
    Moskalik K, Kozlov A, Demin E, et al. The efficacy of facial skin cancer treatment with high-energy pulsed neodymium and Nd:YAG lasers. Photomed Laser Surg. 2009;27:345–9.PubMedCrossRefGoogle Scholar
  22. 22.
    Goldman L, Wilson RG. Treatment of basal cell epithelioma by laser radiation. JAMA. 1964;189:773–5.PubMedCrossRefGoogle Scholar
  23. 23.
    Adams EL, Price NM. Treatment of basal-cell carcinomas with a carbon-dioxide laser. J Dermatol Surg Oncol. 1979;5:803–6.PubMedGoogle Scholar
  24. 24.
    Bailin PL. Use of the Co2 laser for non-port-wine-stain cutaneous lesions. In: Arndt K, Noe JM, Rosen S, editors. Cutaneous laser therapy: principles and methods. New York: Wiley; 1983. p. 187–99.Google Scholar
  25. 25.
    Bilik R, Kahanovich S, Rubin M, et al. Morbidity and recurrence rates after surgical treatment of malignant melanoma by scalpel versus CO2 laser beam. Surg Gynecol Obstet. 1987;165:333–8.PubMedGoogle Scholar
  26. 26.
    Lejeune FJ, Van Hoof G, Gerard A. Impairment of skin graft take after CO2 laser surgery in melanoma patients. Br J Surg. 1980;67:318–20.PubMedCrossRefGoogle Scholar
  27. 27.
    Stanley RJ, Roenigk RK. Actinic cheilitis: treatment with the carbon dioxide laser. Mayo Clin Proc. 1988;63:230–5.PubMedCrossRefGoogle Scholar
  28. 28.
    Shimizu I, Cruz A, Chang KH, et al. Treatment of squamous cell carcinoma in situ: a review. Dermatol Surg. 2011;37:1394–411.PubMedCrossRefGoogle Scholar
  29. 29.
    Bain L, Geronemus R. The association of lichen planus of the penis with squamous cell carcinoma in situ and with verrucous squamous carcinoma. J Dermatol Surg Oncol. 1989;15:413–7.PubMedCrossRefGoogle Scholar
  30. 30.
    Eliezri YD. The toluidine blue test: an aid in the diagnosis and treatment of early squamous cell carcinomas of mucous membranes. J Am Acad Dermatol. 1988;18:1339–49.PubMedCrossRefGoogle Scholar
  31. 31.
    Greenbaum SS, Glogau R, Stegman SJ, et al. Carbon dioxide laser treatment of erythroplasia of Queyrat. J Dermatol Surg Oncol. 1989;15:747–50.PubMedCrossRefGoogle Scholar
  32. 32.
    King CM, Yates VM, Dave VK. Multicentric pigmented Bowen’s disease of the genitalia associated with carcinoma in situ of the cervix. Br J Vener Dis. 1984;60:406–8.PubMedGoogle Scholar
  33. 33.
    Wollina U, Konrad H, Karamfilov T. Treatment of common warts and actinic keratoses by Er:YAG laser. J Cutan Laser Ther. 2001;3:63–6.PubMedCrossRefGoogle Scholar
  34. 34.
    Jiang SB, Levine VJ, Nehal KS, et al. Er:YAG laser for the treatment of actinic keratoses. Dermatol Surg. 2000;26:437–40.PubMedCrossRefGoogle Scholar
  35. 35.
    Iyer S, Friedli A, Bowes L, et al. Full face laser resurfacing: therapy and prophylaxis for actinic keratoses and non-melanoma skin cancer. Lasers Surg Med. 2004;34:114–9.PubMedCrossRefGoogle Scholar
  36. 36.
    Grunt TW, Lametschwandtner A, Staindl O. The vascular pattern of basal cell tumors: light microscopy and scanning electron microscopic study on vascular corrosion casts. Microvasc Res. 1985;29:371–86.PubMedCrossRefGoogle Scholar
  37. 37.
    DeFatta RJ, Krishna S, Williams 3rd EF. Pulsed-dye laser for treating ecchymoses after facial cosmetic procedures. Arch Facial Plast Surg. 2009;11:99–103.PubMedCrossRefGoogle Scholar
  38. 38.
    Shah SM, Konnikov N, Duncan LM, et al. The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas. Lasers Surg Med. 2009;41:417–22.PubMedCrossRefGoogle Scholar
  39. 39.
    Konnikov N, Avram M, Jarell A, et al. Pulsed dye laser as a novel non-surgical treatment for basal cell carcinomas: response and follow up 12–21 months after treatment. Lasers Surg Med. 2011;43:72–8.PubMedCrossRefGoogle Scholar
  40. 40.
    Smucler R, Vlk M. Combination of Er:YAG laser and photodynamic therapy in the treatment of nodular basal cell carcinoma. Lasers Surg Med. 2008;40:153–8.PubMedCrossRefGoogle Scholar
  41. 41.
    Whitaker IS, Shokrollahi K, James W, et al. Combined CO(2) laser with photodynamic therapy for the treatment of nodular basal cell carcinomas. Ann Plast Surg. 2007;59:484–8.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Michael P. McLeod
    • 1
  • Katherine M. Ferris
    • 2
  • Sonal Choudhary
    • 1
  • Yasser A. Alqubaisy
    • 1
  • Keyvan Nouri
    • 1
    • 3
  1. 1.Department of Dermatology and Cutaneous SurgeryUniversity of Miami Leonard M. Miller School of MedicineMiamiUSA
  2. 2.Department of Dermatology and Cutaneous SurgeryUniversity of Miami HospitalMiamiUSA
  3. 3.Department of DermatologySylvester Comprehensive Cancer Center/University of Miami Hospital and ClinicsMiamiUSA

Personalised recommendations