Effect of Dietary Phytochemicals on Metabolic Syndrome and Neurological Disorders

  • Akhlaq A. Farooqui


The widespread prevalence and deleterious effects of MetS have become a major public health challenge as it is associated with the development of type II diabetes, cardiovascular diseases, and age-related neurological disorders. This situation is caused by the consumption of Western diet, which is enriched in saturated and n-6 fatty acids and cholesterol. These dietary components may be responsible for induction of insulin resistance and maintenance of oxidative stress, and inflammation. In contrast, the consumption of diet enriched in fruits (polyphenols), vegetables (fiber), dry fruits (n-3 fatty acids, proteins of plant origin), and whole grains sensitizes insulin and decreases oxidative stress and inflammation by lowering levels of ROS, AGEs, lipid mediators, and cytokines. Thus, lifestyle modifications involving changes in diet and exercise may produce promising effects in managing MetS, diabetes, cardiovascular disease risk, and neurological disorders.


Alzheimer Disease Parkinson Disease Western Diet Ginkgo Biloba Extract Diallyl Trisulfide 
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Akhlaq A. Farooqui
    • 1
  1. 1.Ohio State UniversityColumbusUSA

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