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Sialic Acid Binding Immunoglobulin-Like Lectin-3 (CD33)

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Genetic Variants in Alzheimer's Disease

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Abstract

CD33 (siglec-3) is a member of the family of immunoglobulin containing siglecs. Expressed in myeloid cells, CD33 contains an inhibitory motif which responds to the extracellular “sialoglycome” to dampen immune responses. Genetic variants within anti-inflammatory signalling proteins may contribute to the hyper-inflammatory state associated with Alzheimer’s disease brain. However, the genetic evidence implicating CD33 in Alzheimer’s disease requires independent replication before translational research can be embarked on.

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Author information

Authors and Affiliations

  1. Human Genetics, School of Molecular Medical Sciences, Queen’s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK

    Christopher Medway & Kevin Morgan

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  1. Christopher Medway
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  2. Kevin Morgan
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Correspondence to Christopher Medway .

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Editors and Affiliations

  1. Queen's Medical Centre, School of Molecular Medical Sciences, University of Nottingham, Hucknall Road, Nottingham, NG7 2UH, United Kingdom

    Kevin Morgan

  2. , Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, 32224, USA

    Minerva M. Carrasquillo

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Medway, C., Morgan, K. (2013). Sialic Acid Binding Immunoglobulin-Like Lectin-3 (CD33). In: Morgan, K., Carrasquillo, M. (eds) Genetic Variants in Alzheimer's Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7309-1_9

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