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Genetic Variants in Alzheimer's Disease pp 191–199Cite as

Erythropoietin-Producing Human Hepatocellular Carcinoma (EphA1)

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Abstract

Eph-like receptors belong to the receptor tyrosine kinase family and are divided into two classes, A and B, based on their extracellular domains and the ephrin ligands that they bind. Eph signalling is complex as the two classes of receptors can interact to form functional “clusters” and the receptors themselves are capable of signalling. EphA1 is expressed in multiple tissues and is involved in cell adhesion and organisation of a range of developmental and physiological processes. In the CNS, EphA1 is involved in neural development, synapse plasticity and dendritic spine morphogenesis, suggesting that these receptors may be important as modifiers of neurodegenerative disease. A polymorphism (rs11767557) 3,154 bp upstream of EPHA1 has been significantly associated with Alzheimer’s disease in Caucasian cohorts; however, the functional variant remains unknown. Ephrin receptor signalling operates on known AD pathology pathways. Some ephrin receptors require processing by γ–secretase, which has previously been linked to AD. Furthermore, the role of ephrin receptors in neurodevelopment and spine morphology in AD areas of the brain suggests that differences in neural circuitry may be at fault.

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Authors and Affiliations

  1. Human Genetics, School of Molecular Medical Sciences, Queen’s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK

    Christopher Medway, Anne Braae & Kevin Morgan

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  1. Christopher Medway
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  2. Anne Braae
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  3. Kevin Morgan
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Correspondence to Christopher Medway .

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Editors and Affiliations

  1. Queen's Medical Centre, School of Molecular Medical Sciences, University of Nottingham, Hucknall Road, Nottingham, NG7 2UH, United Kingdom

    Kevin Morgan

  2. , Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, 32224, USA

    Minerva M. Carrasquillo

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Medway, C., Braae, A., Morgan, K. (2013). Erythropoietin-Producing Human Hepatocellular Carcinoma (EphA1). In: Morgan, K., Carrasquillo, M. (eds) Genetic Variants in Alzheimer's Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7309-1_10

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