Skip to main content

Ovarian Cancer

  • Chapter
  • First Online:
Atlas of Gynecologic Oncology Imaging

Part of the book series: Atlas of Oncology Imaging ((AOI))

  • 2264 Accesses

Abstract

The ovaries are paired pelvic organs typically found below the bifurcation of the common iliac vessels lateral to the uterus. They are responsible for hormone secretion and the production of female reproductive cells. Histologically, the ovaries are composed of follicles embedded in a mesh of stroma formed of connective tissue and spindle cells and covered by a layer of surface epithelium. Abnormal proliferation of any of the tissue types can result in both benign and malignant ovarian tumors.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 2011;61:212–36. doi:10.3322/caac.20121.

    Article  PubMed  Google Scholar 

  2. Omura GA, Brady MF, Homesley HD, et al. Long-term follow-up and prognostic factor analysis in advanced ovarian carcinoma: the Gynecologic Oncology Group experience. J Clin Oncol. 1991;9:1138–50.

    PubMed  CAS  Google Scholar 

  3. Ramirez I. The role of surgery in the management of epithelial ovarian cancer. Cancer Control. 2011;18:22–30.

    PubMed  Google Scholar 

  4. Vergote I, Trope CG, Amant F, et al. Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer. N Engl J Med. 2010;363:943–53. doi:10.1056/NEJMoa0908806.

    Article  PubMed  CAS  Google Scholar 

  5. Jung SE, Lee JM, Rha SE, Byun JY, Jung JI, Hahn ST. CT and MR imaging of ovarian tumors with emphasis on differential diagnosis. Radiographics. 2002;22:1305–25.

    Article  PubMed  Google Scholar 

  6. Timmerman D, Ameye L, Fischerova D, et al. Simple ultrasound rules to distinguish between benign and malignant adnexal masses before surgery: prospective validation by IOTA group. BMJ. 2010;341:c6839. doi:10.1136/bmj.c6839.

    Article  PubMed  Google Scholar 

  7. Spencer JA, Gore RM. The adnexal incidentaloma: a practical approach to management. Cancer Imaging. 2011;11:48–51. doi:10.1102/1470-7330.2011.0008.

    Article  PubMed  Google Scholar 

  8. Levine D, Brown DL, Andreotti RF, et al. Management of asymptomatic ovarian and other adnexal cysts imaged at US Society of Radiologists in Ultrasound Consensus Conference Statement. Radiology. 2010;256:943–54. doi:10.1148/radiol.10100213.

    Article  PubMed  Google Scholar 

  9. Spencer JA, Forstner R, Cunha TM, Kinkel K. ESUR guidelines for MR imaging of the sonographically indeterminate adnexal mass: an algorithmic approach. Eur Radiol. 2010;20:25–35.

    Article  PubMed  Google Scholar 

  10. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A, editors. AJCC cancer staging manual. 7th ed. New York: Springer; 2010.

    Google Scholar 

  11. FIGO Committee on Gynecologic Oncology. Current FIGO staging for cancer of the vagina, fallopian tube, ovary, and gestational trophoblastic neoplasia. Int J Gynaecol Obstet. 2009;105:3–4.

    Article  Google Scholar 

  12. Mironov O, Ishill NM, Mironov S, et al. Pleural effusion detected at CT prior to primary cytoreduction for stage III or IV ovarian carcinoma: effect on survival. Radiology. 2011;258:776–84.

    Article  PubMed  Google Scholar 

  13. Tempany CM, Zou KH, Silverman SG, Brown DL, Kurtz AB, McNeil BJ. Staging of advanced ovarian cancer: comparison of imaging modalities–report from the Radiological Diagnostic Oncology Group. Radiology. 2000;215:761–7.

    PubMed  CAS  Google Scholar 

  14. Coakley FV. Staging ovarian cancer: role of imaging. Radiol Clin North Am. 2002;40:609–36. doi:10.1007/s00330-010-1886-4.

    Article  PubMed  Google Scholar 

  15. Forstner R, Sala E, Kinkel K, Spencer JA. ESUR guidelines: ovarian cancer staging and follow-up. Eur Radiol. 2010;20:2773–80.

    Article  PubMed  Google Scholar 

  16. Ricke J, Sehouli J, Hach C, Hanninen EL, Lichtenegger W, Feliz R. Prospective evaluation of contrast-enhanced MRI in the depiction of peritoneal spread in primary or recurrent ovarian cancer. Eur Radiol. 2003;13:943–9. doi:10.1148/radiol.2482070371.

    Article  PubMed  Google Scholar 

  17. Akin O, Sala E, Moskowitz CS, et al. Perihepatic metastases from ovarian cancer: sensitivity and specificity of CT for the detection of metastases with and those without liver parenchymal invasion. Radiology. 2008;248:511–7. doi:10.1148/radiol.10100162.

    Article  PubMed  Google Scholar 

  18. Rustin G, Tuxen M. Use of CA 125 in follow-up of ovarian cancer. Lancet. 1996;348(9021):191–2. doi:S0140673696240292 [pii].

    Article  PubMed  CAS  Google Scholar 

  19. Tuxen MK, Soletormos G, Dombernowsky P. Tumor markers in the management of patients with ovarian cancer. Cancer Treat Rev. 1995;21:215–45.

    Article  PubMed  CAS  Google Scholar 

  20. Folk JJ, Botsford M, Musa AG. Monitoring cancer antigen 125 levels in induction chemotherapy for epithelial ovarian carcinoma and predicting outcome of second-look procedure. Gynecol Oncol. 1995;57:178–82. doi:10.1006/gyno.1995.1121.

    Article  PubMed  CAS  Google Scholar 

  21. Patsner B, Orr Jr JW, Mann Jr WJ, Taylor PT, Partridge E, Allmen T. Does serum CA-125 level prior to second-look laparotomy for invasive ovarian adenocarcinoma predict size of residual disease? Gynecol Oncol. 1990;38:373–6. doi:10.1016/0090-8258(90)90076-W [pii].

    Article  PubMed  CAS  Google Scholar 

  22. Rubin SC, Hoskins WJ, Hakes TB, et al. Serum CA 125 levels and surgical findings in patients undergoing secondary operations for epithelial ovarian cancer. Am J Obstet Gynecol. 1989;160:667–71.

    Article  PubMed  CAS  Google Scholar 

  23. Low RN, Duggan B, Barone RM, Saleh F, Song SY. Treated ovarian cancer: MR imaging, laparotomy reassessment, and serum CA-125 values compared with clinical outcome at 1 year. Radiology. 2005;235:918–26.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Oguz Akin MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this chapter

Cite this chapter

Vargas, H.A., Di Paolo, P.L., Afaq, A., Akin, O. (2014). Ovarian Cancer. In: Akin, O. (eds) Atlas of Gynecologic Oncology Imaging. Atlas of Oncology Imaging. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7212-4_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-7212-4_1

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7211-7

  • Online ISBN: 978-1-4614-7212-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics