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The Aging Male and Impact on Offspring

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Biennial Review of Infertility

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Abstract

Advancing age is known to severely affect female fertility with correlations to increased spontaneous abortions, chromosomal defects in offspring, preterm delivery, and intrauterine growth restriction. In contrast, the effect of advanced paternal age has received far less attention. This is likely a result of the absence of such striking effects compared with those associated with maternal aging. Nevertheless, recent data suggesting an association between advanced paternal age and neuropsychiatric disorders in offspring have increased the attention given to the effects of paternal age on sperm quality and to offspring health and disease susceptibility. We have learned from many recent studies that paternal aging does significantly affect fecundity in males through declines in semen parameters and increases in genetic and epigenetic abnormalities. The identification of these risks and their coverage in popular media require that physicians are well versed in the data and are able to communicate the relative risks of paternal aging on offspring health in addition to interpreting the absolute risk of these abnormalities to concerned patients. This chapter will review the current literature regarding male age-associated changes to semen parameters and the effects of advanced paternal age on offspring disease risk. We will also attempt to put these risks into clinical context.

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Authors and Affiliations

  1. Andrology and IVF Laboratories, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA

    Timothy G. Jenkins B.S.

  2. Andrology and IVF Laboratories, Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA

    Kenneth I. Aston Ph.D., H.C.L.D. & Douglas T. Carrell Ph.D., H.C.L.D.

  3. Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT, USA

    Douglas T. Carrell Ph.D., H.C.L.D.

  4. Department of Human Genetics, University of Utah School of Medicine, 675 Arapeen Dr. Suite 201, Salt Lake City, 84108, UT, USA

    Douglas T. Carrell Ph.D., H.C.L.D.

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  1. Timothy G. Jenkins B.S.
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  2. Kenneth I. Aston Ph.D., H.C.L.D.
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Correspondence to Douglas T. Carrell Ph.D., H.C.L.D. .

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Editors and Affiliations

  1. Weill Cornell Medical Center, Dept. Urology, New York Presbyterian Hospital, East 68th St. 525, New York, 10021, New York, USA

    Peter N. Schlegel

  2. , Department of Reproductive Medicine, University Medical Center Utrecht, PO Box 85500, Utrecht, 3508 GA, Netherlands

    Bart C. Fauser

  3. S. Arapeen Drive 675, Salt Lake, 84108, Utah, USA

    Douglas T. Carrell

  4. and Infertility, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinlogy, Francis St. 75, Boston, 02115, Massachusetts, USA

    Catherine Racowsky

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Jenkins, T.G., Aston, K.I., Carrell, D.T. (2013). The Aging Male and Impact on Offspring. In: Schlegel, P., Fauser, B., Carrell, D., Racowsky, C. (eds) Biennial Review of Infertility. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7187-5_3

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