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Supplements to Enhance Male Fertility

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Biennial Review of Infertility

Abstract

The role of nutritional supplements in enhancing male fertility is a subject of substantial interest for patients and medical practitioners. Nutritional supplements are presumed to have antioxidant activity that may protect sperm integrity, enhance motility, and/or improve sperm production. Published data on these supplements are very limited. Most studies involve treatment with multiple agents. A recent Cochran meta-analysis suggests that supplements may enhance male fertility potential. A critical review of this report and the potential clinical role of supplements are provided. Existent data do not allow clinicians to make a rational recommendation of whether a male interested in enhancing fertility should take supplements, or what agent or dose to take.

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References

  1. Lewis SE. Is sperm evaluation useful in predicting human fertility? Reproduction. 2007;134(1):31–40.

    Article  PubMed  CAS  Google Scholar 

  2. Kefer JC, Agarwal A, Sabanegh E. Role of antioxidants in the treatment of male infertility. Int J Urol. 2009;16(5):449–57.

    Article  PubMed  CAS  Google Scholar 

  3. Showell MG, Brown J, Yazdani A, et al. Antioxidants for male subfertility. Cochrane Database Syst Rev. 2011;1:CD007411.

    PubMed  Google Scholar 

  4. Ross C, Morriss A, Khairy M, et al. A systematic review of the effect of oral antioxidants on male infertility. Reprod Biomed Online. 2010;20(6):711–23.

    Article  PubMed  CAS  Google Scholar 

  5. Fraga CG, Motchnik PA, Shigenaga MK, et al. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci USA. 1991;88(24):11003–6.

    Article  PubMed  CAS  Google Scholar 

  6. Dawson EB, Harris WA, Rankin WE, et al. Effect of ascorbic acid on male fertility. Ann N Y Acad Sci. 1987;498:312–23.

    Article  PubMed  CAS  Google Scholar 

  7. Omu AE, Al-Azemi MK, Kehinde EO, et al. Indications of the mechanisms involved in improved sperm parameters by zinc therapy. Med Princ Pract. 2008;17(2):108–16.

    Article  PubMed  CAS  Google Scholar 

  8. Ursini F, Heim S, Kiess M, et al. Dual function of the selenoprotein PHGPx during sperm maturation. Science. 1999;285(5432):1393–6.

    Article  PubMed  CAS  Google Scholar 

  9. Murphy LE, Mills JL, Molloy AM, et al. Folate and vitamin B12 in idiopathic male infertility. Asian J Androl. 2011;13(6):856–61.

    Article  PubMed  CAS  Google Scholar 

  10. Cavallini G, Ferraretti AP, Gianaroli L, et al. Cinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligo­asthenospermia. J Androl. 2004;25(5):761–70. discussion 71–2.

    PubMed  CAS  Google Scholar 

  11. Klebanov GI, Kapitanov AB, Teselkin Yu O, et al. The antioxidant properties of lycopene. Membr Cell Biol. 1998;12(2):287–300.

    PubMed  CAS  Google Scholar 

  12. Balercia G, Regoli F, Armeni T, et al. Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia. Fertil Steril. 2005;84(3):662–71.

    Article  PubMed  CAS  Google Scholar 

  13. Safarinejad MR, Safarinejad S. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol. 2009;181(2):741–51.

    Article  PubMed  CAS  Google Scholar 

  14. Scott R, MacPherson A, Yates RW, et al. The effect of oral selenium supplementation on human sperm motility. Br J Urol. 1998;82(1):76–80.

    Article  PubMed  CAS  Google Scholar 

  15. Tremellen K, Miari G, Froiland D, et al. A randomised control trial examining the effect of an antioxidant (Menevit) on pregnancy outcome during IVF-ICSI treatment. Aust N Z J Obstet Gynaecol. 2007;47(3):216–21.

    Article  PubMed  Google Scholar 

  16. Kessopoulou E, Powers HJ, Sharma KK, et al. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertil Steril. 1995;64(4):825–31.

    PubMed  CAS  Google Scholar 

  17. Suleiman SA, Ali ME, Zaki ZM, et al. Lipid peroxidation and human sperm motility: protective role of vitamin E. J Androl. 1996;17(5):530–7.

    PubMed  CAS  Google Scholar 

  18. Bjelakovic G, Nikolova D, Gluud LL, et al. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA. 2007;297(8):842–57.

    Article  PubMed  CAS  Google Scholar 

  19. Collins JA, Barnhart KT, Schlegel PN. Do sperm DNA integrity tests predict pregnancy with in vitro fertilization? Fertil Steril. 2008;89(4):823–31.

    Article  PubMed  Google Scholar 

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Correspondence to Peter N. Schlegel M.D. .

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Schlegel, P.N. (2013). Supplements to Enhance Male Fertility. In: Schlegel, P., Fauser, B., Carrell, D., Racowsky, C. (eds) Biennial Review of Infertility. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7187-5_1

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  • DOI: https://doi.org/10.1007/978-1-4614-7187-5_1

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7186-8

  • Online ISBN: 978-1-4614-7187-5

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