Abstract
It is estimated that over 400,000 embryos remain in storage in the United States. These surplus embryos are the by-products of modern-day assisted reproductive techniques. Couples who have completed childbearing often struggle with decisions regarding the disposition of these embryos. Options include embryo disposal, donation to research, or donation to other infertile couples. Use of these surplus embryos would potentially benefit infertile couples at lower costs compared to fresh in vitro fertilization (IVF) cycles, with costs approaching those of frozen embryo transfer (FET) cycles. Limited data show pregnancy success rates to be comparable to fresh IVF and autologous FET cycles. Eligible donors and recipients should ideally comply with and meet all criteria established by the American Society of Reproductive Medicine prior to embryo donation. While embryo donation has numerous inherent medical and legal challenges, it may be an ideal option for couples who do not find embryo disposal acceptable and wish to help other infertile couples in their efforts to conceive.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Hoffman DI, Zellman GL, Fair CC, Mayer JF, Zeitz JG, Gibbons WE, et al. Cryopreserved embryos in the United States and their availability for research. Fertil Steril. 2003;79(5):1063–9.
Caplan, A. The problem with embryo adoption.24 Jun 2003. www.msnbc.msn.com/id/3076556/ns/…/problem-embryo-adoption/.
Keenan JA, Chang J, Finger RF, Jeng G, Cornman KI, Macaluso M. National surveillance data confirm favorable outcome rates from embryo donation (abstract). Fertil Steril. 2008;90:S209.
Trounson A, Leeton J, Besanko M, Wood C, Conti A. Pregnancy established in an infertile patient after transfer of a donated embryo fertilized in vitro. Br Med J. 1983;286:835–8.
Wurmbrand MJ. Frozen embryos: moral, social, and legal implications. South Calif Law Rev. 1986;59(5): 1079–100.
Devroey P, Camus M, van den Abbeel E, van Waesberghe L, Wisanto A, van Steirteghem AC. Establishment of 22 pregnancies after oocyte and embryo donation. Br J Obstet Gynaecol. 1989;96(8):900–6.
Definition of adopted. www.merriam-webster.com. 2012.
The Ethics Committee of the American Society for Reproductive Medicine. American Society for Reproductive Medicine: defining embryo donation. Fertil Steril. 2009;92:1818.
Louisiana Revised Statutes, 6:126–133. http://www.legis.state.la.us/lss/lss.asp?doc=108443
Georgia Code Title 19, Chapter 8, Article 2. http://www.legis.state.ga.us/legis/2009_10/pdf/hb388.pdf
Crockin SL. The “embryo” wars: at the epicenter of science, law, religion, and politics. Family Law Q. 2005;39(3):599–632.
Meirow D, Biederman H, Anderson RA, Wallace WH. Toxicity of chemotherapy and radiation on female reproduction. Clin Obstet Gynecol. 2010;53(4):727–39. Review.
Howell SJ, Shalet SM. Fertility preservation and management of gonadal failure associated with lymphoma therapy. Curr Oncol Rep. 2002;4(5):443–52.
Stahl PJ, Schlegel PN. Genetic evaluation of the azoospermic or severely oligozoospermic male. Curr Opin Obstet Gynecol. 2012;24(4):221–8.
Lee J, Yap C. Embryo donation: a review. Acta Obstet Gynecol Scand. 2003;82(11):991–6.
Keenan JA, Gissler M, Finger R. Assisted reproduction using donated embryos: outcomes from surveillance systems in six countries. Hum Reprod. 2012;27(3):747–52.
Golombok S, Brewaeys A, Cook R, Giavazzi MT, Guerra D, Mantovani A, et al. The European study of assisted reproduction families: family functioning and child development. Hum Reprod. 1996;11(10):2324–31.
Practice Committee of American Society for Reproductive Medicine; Practice Committee of Society for Assisted Reproductive Technology. Guidelines for gamete and embryo donation: a Practice Committee report. Fertil Steril. 2008;90(5 Suppl):S30–44.
Van Voorhis BJ, Grinstead DM, Sparks AE, Gerard JL, Weir RF. Establishment of a successful donor embryo program: medical, ethical, and policy issues. Fertil Steril. 1999;71(4):604–820.
Devreker F, Englert Y. Implantation rates and embryo numbers. Hum Reprod. 1994;9(2):186.
Chang EM, Han JE, Kim YS, Lyu SW, Lee WS, Yoon TK. Use of the natural cycle and vitrification thawed blastocyst transfer results in better in-vitro fertilization outcomes: cycle regimens of vitrification thawed blastocyst transfer. J Assist Reprod Genet. 2011; 28(4):369–74. Epub 2011 Jan 13.
Glujovsky D, Blake D, Farquhar C, Bardach A. Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology. Cochrane Database Syst Rev. 2012 Jul 11;7:CD002118. Review.
El Bahja D, Hertz P, Schweitzer T, Lestrade F, Ragage JP. [Frozen embryo transfer protocol: Does spontaneous cycle give good results?] Gynecol Obstet Fertil. 2012 Feb 15. [Epub ahead of print].
Glujovsky D, Pesce R, Fiszbajn G, Sueldo C, Hart RJ, Ciapponi A. Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD006359.
Haddad G, Saguan DA, Maxwell R, Thomas MA. Intramuscular route of progesterone administration increases pregnancy rates during non-downregulated frozen embryo transfer cycles. J Assist Reprod Genet. 2007;24(10):467–70.
Yanushpolsky E, Hurwitz S, Greenberg L, Racowsky C, Hornstein M. Crinone vaginal gel is equally effective and better tolerated than intramuscular progesterone for luteal phase support in vitro fertilization-embryo transfer cycles: a prospective randomized study. Fertil Steril. 2010;94(7):2596–9.
Bjuresten K, Landgren B-M, Hovatta O, Stavreus-Evers A. Luteal phase progesterone increases live birth rate after frozen embryo transfer. Fertil Steril. 2011;95(2):534–7.
Konc J, Kanyo K, Varga E, Kriston R, Cseh S. The effect of cycle regimen used for endometrium preparation on the outcome of day 3 frozen embryo transfer cycle. Fertil Steril. 2010;94(2):767–8.
Ghobara T, Vandekerckhove P. Cycle regimens for frozen-thawed embryo transfer. Cochrane Database Syst Rev. 2008;1, CD003414.
Life Issues Institute. Embryo Adoption. www.lifeissues.org/embryo_adoption/index.html. 2004
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media New York
About this chapter
Cite this chapter
Patel, B.G., Rossi, B.V. (2014). Embryo Donation: Medical Aspects. In: Goldfarb, J. (eds) Third-Party Reproduction. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7169-1_9
Download citation
DOI: https://doi.org/10.1007/978-1-4614-7169-1_9
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-7168-4
Online ISBN: 978-1-4614-7169-1
eBook Packages: MedicineMedicine (R0)