Skip to main content

Embryo Donation: Medical Aspects

  • Chapter
  • First Online:
Third-Party Reproduction

Abstract

It is estimated that over 400,000 embryos remain in storage in the United States. These surplus embryos are the by-products of modern-day assisted reproductive techniques. Couples who have completed childbearing often struggle with decisions regarding the disposition of these embryos. Options include embryo disposal, donation to research, or donation to other infertile couples. Use of these surplus embryos would potentially benefit infertile couples at lower costs compared to fresh in vitro fertilization (IVF) cycles, with costs approaching those of frozen embryo transfer (FET) cycles. Limited data show pregnancy success rates to be comparable to fresh IVF and autologous FET cycles. Eligible donors and recipients should ideally comply with and meet all criteria established by the American Society of Reproductive Medicine prior to embryo donation. While embryo donation has numerous inherent medical and legal challenges, it may be an ideal option for couples who do not find embryo disposal acceptable and wish to help other infertile couples in their efforts to conceive.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Hoffman DI, Zellman GL, Fair CC, Mayer JF, Zeitz JG, Gibbons WE, et al. Cryopreserved embryos in the United States and their availability for research. Fertil Steril. 2003;79(5):1063–9.

    Article  PubMed  Google Scholar 

  2. Caplan, A. The problem with embryo adoption.24 Jun 2003. www.msnbc.msn.com/id/3076556/ns/…/problem-embryo-adoption/.

  3. Keenan JA, Chang J, Finger RF, Jeng G, Cornman KI, Macaluso M. National surveillance data confirm favorable outcome rates from embryo donation (abstract). Fertil Steril. 2008;90:S209.

    Article  Google Scholar 

  4. Trounson A, Leeton J, Besanko M, Wood C, Conti A. Pregnancy established in an infertile patient after transfer of a donated embryo fertilized in vitro. Br Med J. 1983;286:835–8.

    Article  CAS  Google Scholar 

  5. Wurmbrand MJ. Frozen embryos: moral, social, and legal implications. South Calif Law Rev. 1986;59(5): 1079–100.

    PubMed  Google Scholar 

  6. Devroey P, Camus M, van den Abbeel E, van Waesberghe L, Wisanto A, van Steirteghem AC. Establishment of 22 pregnancies after oocyte and embryo donation. Br J Obstet Gynaecol. 1989;96(8):900–6.

    Article  PubMed  CAS  Google Scholar 

  7. Definition of adopted. www.merriam-webster.com. 2012.

  8. The Ethics Committee of the American Society for Reproductive Medicine. American Society for Reproductive Medicine: defining embryo donation. Fertil Steril. 2009;92:1818.

    Article  Google Scholar 

  9. Louisiana Revised Statutes, 6:126–133. http://www.legis.state.la.us/lss/lss.asp?doc=108443

  10. Georgia Code Title 19, Chapter 8, Article 2. http://www.legis.state.ga.us/legis/2009_10/pdf/hb388.pdf

  11. Crockin SL. The “embryo” wars: at the epicenter of science, law, religion, and politics. Family Law Q. 2005;39(3):599–632.

    Google Scholar 

  12. Meirow D, Biederman H, Anderson RA, Wallace WH. Toxicity of chemotherapy and radiation on female reproduction. Clin Obstet Gynecol. 2010;53(4):727–39. Review.

    Article  PubMed  Google Scholar 

  13. Howell SJ, Shalet SM. Fertility preservation and management of gonadal failure associated with lymphoma therapy. Curr Oncol Rep. 2002;4(5):443–52.

    Article  PubMed  Google Scholar 

  14. Stahl PJ, Schlegel PN. Genetic evaluation of the azoospermic or severely oligozoospermic male. Curr Opin Obstet Gynecol. 2012;24(4):221–8.

    Article  PubMed  Google Scholar 

  15. Lee J, Yap C. Embryo donation: a review. Acta Obstet Gynecol Scand. 2003;82(11):991–6.

    Article  PubMed  Google Scholar 

  16. Keenan JA, Gissler M, Finger R. Assisted reproduction using donated embryos: outcomes from surveillance systems in six countries. Hum Reprod. 2012;27(3):747–52.

    Article  PubMed  Google Scholar 

  17. Golombok S, Brewaeys A, Cook R, Giavazzi MT, Guerra D, Mantovani A, et al. The European study of assisted reproduction families: family functioning and child development. Hum Reprod. 1996;11(10):2324–31.

    Article  PubMed  CAS  Google Scholar 

  18. Practice Committee of American Society for Reproductive Medicine; Practice Committee of Society for Assisted Reproductive Technology. Guidelines for gamete and embryo donation: a Practice Committee report. Fertil Steril. 2008;90(5 Suppl):S30–44.

    Google Scholar 

  19. Van Voorhis BJ, Grinstead DM, Sparks AE, Gerard JL, Weir RF. Establishment of a successful donor embryo program: medical, ethical, and policy issues. Fertil Steril. 1999;71(4):604–820.

    Article  PubMed  Google Scholar 

  20. Devreker F, Englert Y. Implantation rates and embryo numbers. Hum Reprod. 1994;9(2):186.

    PubMed  CAS  Google Scholar 

  21. Chang EM, Han JE, Kim YS, Lyu SW, Lee WS, Yoon TK. Use of the natural cycle and vitrification thawed blastocyst transfer results in better in-vitro fertilization outcomes: cycle regimens of vitrification thawed blastocyst transfer. J Assist Reprod Genet. 2011; 28(4):369–74. Epub 2011 Jan 13.

    Article  PubMed  Google Scholar 

  22. Glujovsky D, Blake D, Farquhar C, Bardach A. Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology. Cochrane Database Syst Rev. 2012 Jul 11;7:CD002118. Review.

    Google Scholar 

  23. El Bahja D, Hertz P, Schweitzer T, Lestrade F, Ragage JP. [Frozen embryo transfer protocol: Does spontaneous cycle give good results?] Gynecol Obstet Fertil. 2012 Feb 15. [Epub ahead of print].

    Google Scholar 

  24. Glujovsky D, Pesce R, Fiszbajn G, Sueldo C, Hart RJ, Ciapponi A. Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD006359.

    Google Scholar 

  25. Haddad G, Saguan DA, Maxwell R, Thomas MA. Intramuscular route of progesterone administration increases pregnancy rates during non-downregulated frozen embryo transfer cycles. J Assist Reprod Genet. 2007;24(10):467–70.

    Article  PubMed  Google Scholar 

  26. Yanushpolsky E, Hurwitz S, Greenberg L, Racowsky C, Hornstein M. Crinone vaginal gel is equally effective and better tolerated than intramuscular progesterone for luteal phase support in vitro fertilization-embryo transfer cycles: a prospective randomized study. Fertil Steril. 2010;94(7):2596–9.

    Article  PubMed  CAS  Google Scholar 

  27. Bjuresten K, Landgren B-M, Hovatta O, Stavreus-Evers A. Luteal phase progesterone increases live birth rate after frozen embryo transfer. Fertil Steril. 2011;95(2):534–7.

    Article  PubMed  CAS  Google Scholar 

  28. Konc J, Kanyo K, Varga E, Kriston R, Cseh S. The effect of cycle regimen used for endometrium preparation on the outcome of day 3 frozen embryo transfer cycle. Fertil Steril. 2010;94(2):767–8.

    Article  PubMed  Google Scholar 

  29. Ghobara T, Vandekerckhove P. Cycle regimens for frozen-thawed embryo transfer. Cochrane Database Syst Rev. 2008;1, CD003414.

    PubMed  Google Scholar 

  30. Life Issues Institute. Embryo Adoption. www.lifeissues.org/embryo_adoption/index.html. 2004

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Bonnie G. Patel M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this chapter

Cite this chapter

Patel, B.G., Rossi, B.V. (2014). Embryo Donation: Medical Aspects. In: Goldfarb, J. (eds) Third-Party Reproduction. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7169-1_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-7169-1_9

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7168-4

  • Online ISBN: 978-1-4614-7169-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics