Advertisement

Emotion, Interventions, and Immunity

  • Kyung Bong KohEmail author
Chapter

Abstract

Psychological stress can alter one’s immune function and increase susceptibility to physical disease [1–3]. It can be assumed that negative events (stressors) lead to negative affective states (distress), producing alterations in human immunity [4]. For example, an individual’s emotional states, such as anxiety or depression, can be key factors in triggering immune alterations [4, 5].

Keywords

Natural Killer Cell Major Depressive Disorder Panic Disorder Natural Killer Cell Activity Cognitive Behavioral Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Elliot, G. R., & Eisengdorfer, C. (1982). Stress and human health: Analysis and implications of research, A Study by the Institute of Medicine and the National Academy of Sciences, New York: Springer.Google Scholar
  2. 2.
    Herberman, R. B. (1982). NK cells and other natural effector cells. New York: Academic Press.Google Scholar
  3. 3.
    Levy, L. (1974). Psychosocial stress and disease: A conceptual model. In E. K. Gunderson & R. H. Rahe (Eds.), Life stress and illness. Springfield, MA: Thomas.Google Scholar
  4. 4.
    Herbert, T. B., & Cohen, S. (1993). Depression and immunity: A meta-analytic review. Psychological Bulletin, 113, 472–486.PubMedCrossRefGoogle Scholar
  5. 5.
    Weisse, C. S. (1992). Depression and immunocompetence: A review of the literature. Psychological Bulletin, 111, 475–489.PubMedCrossRefGoogle Scholar
  6. 6.
    Locke, S. E., & Gorman, J. R. (1989). Behavior and immunity. In H. I. Kaplan & B. J. Sadock (Eds.), Comprehensive textbook of psychiatry. Baltimore, MD: Williams & Wilkins.Google Scholar
  7. 7.
    Camara, E. G., & Danao, T. C. (1989). The brain and the immune system: A psychosomatic network. Psychosomatics, 30, 140–146.PubMedCrossRefGoogle Scholar
  8. 8.
    Bartrop, R. W., Luckhurst, E., & Lazarus, L. (1977). Depressed lymphocyte function after bereavement. Lancet, 1, 834–836.PubMedCrossRefGoogle Scholar
  9. 9.
    Tecoma, E. S., & Huey, L. Y. (1985). Psychic distress and the immune response. Life Sciences, 36, 1799–1812.PubMedCrossRefGoogle Scholar
  10. 10.
    Calabrese, J. R., Skwerer, R. G., Barna, B., et al. (1986). Depression, immunocompetence, and prostaglandins of the E series. Psychiatry Research, 17, 41–47.PubMedCrossRefGoogle Scholar
  11. 11.
    Perez, M., & Farrant, J. (1988). Immune reactions and mental disorders (editorial). Psychosomatic Medicine, 18, 11–13.Google Scholar
  12. 12.
    Hickie, I., Silove, D., & Hickie, C. (1990). Is there immune dysfunction in depressive disorders? Psychological Medicine, 20, 755–761.PubMedCrossRefGoogle Scholar
  13. 13.
    Khansari, D. N., Murugo, A. H., & Faith, R. E. (1990). Effects of stress on the immune system. Immunology Today, 11, 170–175.PubMedCrossRefGoogle Scholar
  14. 14.
    Kiecolt-Glaser, J. K., & Glaser, R. (1992). Stress and the immune system: Human studies. In A. Tasman & M. B. Riba (Eds.), American psychiatric press review of psychiatry (Vol. 11). Washington, DC: American Psychiatric Press.Google Scholar
  15. 15.
    Weiss, J. M., & Sundar, S. (1992). Effects of stress on cellular immune responses in animals. In A. Tasman & M. B. Riba (Eds.), American psychiatric press review of psychiatry (Vol. 11). Washington, DC: American Psychiatric Press.Google Scholar
  16. 16.
    Kelley, K. W. (1985). Immunological consequences of changing environmental stimuli. In G. Moberg (Ed.), Animal stress. Bethesda, MD: American Psychological Society.Google Scholar
  17. 17.
    Kiecolt-Glaser, J. K., & Glaser, R. (1986). Psychological influences on immunity. Psychosomatics, 27, 621–624.CrossRefGoogle Scholar
  18. 18.
    Glaser, R., Rice, J., Speicher, C. E., et al. (1986). Stress depresses interferon production and natural killer (NK) cell activity in humans. Behavioral Neuroscience, 100, 675–678.PubMedCrossRefGoogle Scholar
  19. 19.
    Glaser, R., Rice, J., Sheridan, J., et al. (1987). Stress-related immune suppression: Health implications. Brain, Behavior, and Immunity, 1, 7–20.PubMedCrossRefGoogle Scholar
  20. 20.
    Marchesi, G. F., Cotani, P., Santone, G., et al. (1989). Psychological and immunological relationships during acute academic stress. New Trends in Experimental and Clinical Psychiatry, 5, 5–22.Google Scholar
  21. 21.
    Glaser, R., Kennedy, S., Lafuse, W. P., et al. (1990). Psychological stress-induced modulation of interleukin-2 receptor gene expression and interleukin-2 production in peripheral blood leukocytes. Archives of General Psychiatry, 47, 702–712.CrossRefGoogle Scholar
  22. 22.
    Dobbin, J. P., Harth, M., Mccain, G. A., et al. (1991). Cytokine production and lymphocyte transformation during stress. Brain, Behavior, and Immunity, 5, 339–348.PubMedCrossRefGoogle Scholar
  23. 23.
    Glaser, R., Pearson, G. R., Jones, J. F., et al. (1991). Stress-related activation of Epstein-Barr virus. Brain, Behavior, and Immunity, 5, 219–232.PubMedCrossRefGoogle Scholar
  24. 24.
    Fawzy, F. I. (1995). Behavior and immunity. In H. I. Kaplan & B. J. Sodock (Eds.), Comprehensive textbook of psychiatry. Baltimore, MD: Willams & Wilkins.Google Scholar
  25. 25.
    Deinzer, R., & Schuller, N. (1998). Dynamics of stress-related decrease of salivary immunoglobulin A (sIgA): Relationship to symptoms of the common cold and studying behavior. Behavioral Medicine, 23, 161–169.PubMedCrossRefGoogle Scholar
  26. 26.
    Marucha, D. T., Kiecolt-Glaser, J. K., & Favagehi, M. (1998). Mucosal wound healing is impaired by examination stress. Psychosomatic Medicine, 60, 362–365.PubMedGoogle Scholar
  27. 27.
    Rojas, I. G., Padgett, D. A., Sheridan, J. F., et al. (2002). Stress-induced susceptibility to bacterial infection during cutaneous wound healing. Brain, Behavior, and Immunity, 16, 74–84.PubMedCrossRefGoogle Scholar
  28. 28.
    Bosch, J. A., Brand, H. S., Ligtenberg, A. J. M., et al. (1998). The response of salivary protein levels and S-IgA to an academic examination are associated with daily stress. Journal of Psychophysiology, 4, 170–178.Google Scholar
  29. 29.
    Kang, D., Coe, C. L., & McCarthy, D. O. (1996). Academic examinations significantly impact immune responses, but not lung function, in healthy and well-managed asthmatic adolescents. Brain, Behavior, and Immunity, 10, 164–181.PubMedCrossRefGoogle Scholar
  30. 30.
    Koh, K. B. (2001). The relationship of stress-induced hypothalamic-pituitary-adrenal axis function with cell-mediated immunity. Journal of Korean Neuropsychiatric Association, 40, 857–866.Google Scholar
  31. 31.
    Koh, K. B., Choe, E., Song, J. E., et al. (2006). Effect of coping on endocrinoimmune functions in different stress situations. Psychiatry Research, 143, 223–234.PubMedCrossRefGoogle Scholar
  32. 32.
    Maes, M., van Bockstaele, D. R., Gastel, A. V., et al. (1999). The effects of psychological stress on leukocyte subset distribution in humans: Evidence of immune activation. Neuropsychobiology, 39, 1–9.PubMedCrossRefGoogle Scholar
  33. 33.
    Chrousos, G. P. (1992). The concept of stress and stress system disorders. Journal of the American Medical Association, 267, 1244–1252.PubMedCrossRefGoogle Scholar
  34. 34.
    Koh, K. B. (1998). Emotion and immunity. Journal of Psychosomatic Research, 45, 107–115.PubMedCrossRefGoogle Scholar
  35. 35.
    Chrousos, G. P. (1995). The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. The New England Journal of Medicine, 332, 1351–1362.PubMedCrossRefGoogle Scholar
  36. 36.
    Sternberg, E. M., Chrousos, G. P., Wilder, R. L., et al. (1992). The stress response and the regulation of inflammatory disease. Annals of Internal Medicine, 117, 854–866.PubMedCrossRefGoogle Scholar
  37. 37.
    Maes, M., Song, C., Lin, A., et al. (1998). The effects of psychological stress on humans: Increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety. Cytokine, 10, 313–318.PubMedCrossRefGoogle Scholar
  38. 38.
    Maes, M., Song, C., Lin, A., et al. (1998). Immune and clinical correlates of psychological stress-induced production of interferon—γ and IL-10 in humans. In N. P. Plotnikoff, R. E. Faith, A. J. Murgo, & R. A. Good (Eds.), Cytokines, stress and immunity. Boca Raton, FL: Raven Press.Google Scholar
  39. 39.
    Goebel, M. U., Mills, P. J., Irwin, M. R., et al. (2000). Interleukin-6 and tumor necrosis factor-α production after acute psychological stress, exercise, and infused isoproterenol: Differential effects and pathways. Psychosomatic Medicine, 62, 591–598.PubMedGoogle Scholar
  40. 40.
    Steptoe, A., Willemsen, G., Owen, N., et al. (2001). Acute mental stress elicits delayed increases in circulating inflammatory cytokine levels. Clinical Science, 101, 185–192.PubMedCrossRefGoogle Scholar
  41. 41.
    Segerstrom, S. C., & Miller, G. E. (2004). Psychological stress and the human immune system: A meta-analytic study of 30 years of inquiry. Psychological Bulletin, 130, 601–630.PubMedCrossRefGoogle Scholar
  42. 42.
    Wirtz, P. H., von Kanel, R., Emini, L., et al. (2007). Variations in anticipatory cognitive stress appraisal and differential proinflammatory cytokine expression in response to acute stress. Brain, Behavior, and Immunity, 21, 851–859.PubMedCrossRefGoogle Scholar
  43. 43.
    Koh, K. B., Lee, Y., Beyn, K. M., et al. (2012). Effects of high and low stress on proinflammatory and antiinflammatory cytokines. Psychophysiology, 49, 1290–1297.PubMedCrossRefGoogle Scholar
  44. 44.
    Koh, K. B. (2011). Stress and psychosomatic medicine. Seoul: Ilchokak.Google Scholar
  45. 45.
    Kronfol, A., Silva, J., Gredin, J., et al. (1983). Impaired lymphocyte function in depressive illness. Life Sciences, 33, 241–247.PubMedCrossRefGoogle Scholar
  46. 46.
    Kronfol, Z., & House, J. D. (1984). Depression, cortisol, and immune function. Lancet, 1, 1026–1027.PubMedCrossRefGoogle Scholar
  47. 47.
    Krueger, R. B., Levy, E. M., & Cathcart, E. S. (1984). Lymphocyte subsets in patients with major depression: Preliminary findings. Advances, 1, 5–9.Google Scholar
  48. 48.
    Stein, M., Keller, S. E., & Schleifer, S. J. (1985). Stress and immunomodulation: The role of depression and neuroendocrine function. Journal of Immunology, 135, 827–833.Google Scholar
  49. 49.
    Schleifer, S. J., Keller, S. E., Camereno, M., et al. (1983). Suppression of lymphocyte stimulation following bereavement. Journal of the American Medical Association, 250, 374–377.PubMedCrossRefGoogle Scholar
  50. 50.
    Schleifer, S. J., Keller, S. E., Meyerson, A. T., et al. (1984). Lymphocyte function in major depressive disorder. Archives of General Psychiatry, 41, 484–486.PubMedCrossRefGoogle Scholar
  51. 51.
    Stein, M., Miller, A. H., & Trestman, R. L. (1991). Depression, the immune system, and health and illness. Archives of General Psychiatry, 48, 171–177.PubMedCrossRefGoogle Scholar
  52. 52.
    Maes, M., Bosmans, E., Suy, E., et al. (1989). Impaired lymphocyte stimulation by mitogens in severely depressed patients. The British Journal of Psychiatry, 155, 793–798.PubMedCrossRefGoogle Scholar
  53. 53.
    Hickie, I., Hickie, C., Lloyd, A., et al. (1993). Impaired in vivo immune responses in patients with melancholia. The British Journal of Psychiatry, 162, 651–657.PubMedCrossRefGoogle Scholar
  54. 54.
    Irwin, M. R., & Miller, A. H. (2007). Depressive disorders and immunity: 20 years of progress and discovery. Brain, Behavior, and Immunity, 21, 374–383.PubMedCrossRefGoogle Scholar
  55. 55.
    Zoriller, E. P., Luborsky, L., McKay, J. R., et al. (2001). The relationship of depression and stressors to immunological assays: A meta-analytic review. Brain, Behavior, and Immunity, 15, 199–226.CrossRefGoogle Scholar
  56. 56.
    Eilat, E., Mendlovic, S., Doron, A., et al. (1999). Increased apoptosis in patients with major depression: A preliminary study. Journal of Immunology, 163, 533–534.Google Scholar
  57. 57.
    Ivanova, S. A., Semke, V. Y., Vetlugina, T. P., et al. (2007). Signs of apoptosis of immunocompetent cells in patients with depression. Neuroscience and Behavioral Physiology, 37, 527–530.PubMedCrossRefGoogle Scholar
  58. 58.
    Szuster-Ciesielska, A., Slotwinska, M., Stachura, A., et al. (2008). Accelerated apoptosis of blood leukocytes and oxidative stress in blood of patients with major depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 32, 686–694.CrossRefGoogle Scholar
  59. 59.
    Dantzer, R., O’Connor, J. C., Freund, G. G., et al. (2008). From inflammation to sickness and depression: When the immune system subjugates the brain. Nature Reviews Neuroscience, 9, 46–56.PubMedCrossRefGoogle Scholar
  60. 60.
    Schwarcz, R., & Pellicciari, R. (2002). Manipulation of brain kynurenines: Glial targets, neuronal effects, and clinical opportunities. Journal of Pharmacology and Experimental Therapeutics, 303, 1–10.PubMedCrossRefGoogle Scholar
  61. 61.
    Bonaccorso, S., Marino, V., Puzella, A., et al. (2002). Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonergic system. Journal of Clinical Psychopharmacology, 22, 86–90.PubMedCrossRefGoogle Scholar
  62. 62.
    Capuron, L., Ravaud, A., Neveu, P. J., et al. (2002). Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy. Molecular Psychiatry, 7, 468–473.PubMedCrossRefGoogle Scholar
  63. 63.
    Beisssert, S., Schwarz, A., Schwarz, T., et al. (2006). Regulatory T cells. The Journal of Investigative Dermatology, 126, 15–24.CrossRefGoogle Scholar
  64. 64.
    Mellor, A. L., Munn, D., Chandler, P., et al. (2003). Tryptophan catabolism and T cell responses. Advances in Experimental Medicine and Biology, 527, 27–35.PubMedCrossRefGoogle Scholar
  65. 65.
    McEwen, B. S., Biron, C. A., Brunson, K. W., et al. (1997). The role of adrenocorticoids as modulators of immune function in health and disease: Neural, endocrine and immune interactions. Brain Research Reviews, 23, 79–133.PubMedCrossRefGoogle Scholar
  66. 66.
    Pariante, C. M., & Miller, A. H. (2001). Glucocorticoid receptors in major depression: Relevance to pathophysiology and treatment. Biological Psychiatry, 49, 391–404.PubMedCrossRefGoogle Scholar
  67. 67.
    Kronfol, Z., House, J. D., Silva, J., Jr., et al. (1986). Depression, urinary free cortisol excretion and lymphocyte function. The British Journal of Psychiatry, 148, 70–73.PubMedCrossRefGoogle Scholar
  68. 68.
    Bauer, M. E., Papadopoulos, A., Poon, L., et al. (2003). Altered glucocorticoid immunoregulation in treatment resistant depression. Psychoneuroendocrinology, 28, 49–65.PubMedCrossRefGoogle Scholar
  69. 69.
    Raison, C. L., & Miller, A. H. (2003). When not enough is too much: The role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. The American Journal of Psychiatry, 160, 1554–1565.PubMedCrossRefGoogle Scholar
  70. 70.
    Miller, A. H., Maletic, V., Raison, C. L., et al. (2009). Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression. Biological Psychiatry, 65, 732–741.PubMedCrossRefGoogle Scholar
  71. 71.
    Cope, A. P., Liblau, R. S., Yang, X. D., et al. (1997). Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling. The Journal of Experimental Medicine, 185, 1573–1584.PubMedCrossRefGoogle Scholar
  72. 72.
    Cope, A. P., Londei, M., Chu, N. R., et al. (1994). Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis. The Journal of Clinical Investigation, 94, 749–760.PubMedCrossRefGoogle Scholar
  73. 73.
    Dentino, A. N., Pieper, C. F., Rao, K. M. K., et al. (1999). Association of interleukin-6 and other biologic variables with depression in older people living in the community. Journal of American Geriatrics Society, 47, 6–11.Google Scholar
  74. 74.
    Maes, M., Bosmans, E., Jongh, D., et al. (1995). Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression. Cytokine, 9, 853–858.CrossRefGoogle Scholar
  75. 75.
    Maes, M., Lin, A., Delmeire, L., et al. (1999). Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events. Biological Psychiatry, 45, 833–839.PubMedCrossRefGoogle Scholar
  76. 76.
    Kiecolt-Glaser, J. K., & Glaser, R. (2002). Depression and immune function: Central pathways to morbidity and mortality. Journal of Psychosomatic Research, 53, 873–876.PubMedCrossRefGoogle Scholar
  77. 77.
    Wong, M. L., Dong, C., Maestre-Mesa, J., et al. (2008). Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response. Molecular Psychiatry, 13, 800–812.PubMedCrossRefGoogle Scholar
  78. 78.
    Lewitus, G. M., & Schwartz, M. (2009). Behavioral immunization: Immunity to self-antigens contributes to psychological stress resilience. Molecular Psychiatry, 14, 532–536.PubMedCrossRefGoogle Scholar
  79. 79.
    Lewitus, G. M., Wilf-Yarkoni, A., Ziv, Y., et al. (2009). Vaccination as a novel approach for treating depressive behavior. Biological Psychiatry, 65, 283–288.PubMedCrossRefGoogle Scholar
  80. 80.
    Rook, G. A., & Lowry, C. A. (2008). The hygiene hypothesis and psychiatric disorders. Trends in Immunology, 29, 150–158.PubMedCrossRefGoogle Scholar
  81. 81.
    Miller, A. H. (2010). Depression and immunity: A role for T cells? Brain, Behavior, and Immunity, 24, 1–8.PubMedCrossRefGoogle Scholar
  82. 82.
    La Via, M. F., Workman, E. W., & Lydiard, R. B. (1992). Subtype response to stress-induced immunodepression. Functional Neurology, 7(Supp. 3), 19–22.Google Scholar
  83. 83.
    Linn, B. S., Linn, M. W., & Jensen, J. (1981). Anxiety and immune responsiveness. Psychological Reports, 49, 969–970.PubMedCrossRefGoogle Scholar
  84. 84.
    La Via, M. F., Munno, I., Lydiard, R. B., et al. (1996). The influence of stress intrusion on immunodepression in generalized anxiety disorder patients and controls. Psychosomatic Medicine, 58, 138–142.PubMedGoogle Scholar
  85. 85.
    Marazziti, D., Ambrogi, F., Vanacore, R., et al. (1992). Immune cell imbalance in major depressive and panic disorders. Neuropsychobiology, 26, 23–26.PubMedCrossRefGoogle Scholar
  86. 86.
    Koh, K. B., & Lee, B. K. (1998). Reduced lymphocyte proliferation and interleukin-2 production in anxiety disorders. Psychosomatic Medicine, 60, 479–483.PubMedGoogle Scholar
  87. 87.
    Schleifer, S. J., Keller, S. E., Scotte, B. J., et al. (1990). Lymphocyte function in panic disorder. Biological Psychiatry, 27(suppl.), 66A.Google Scholar
  88. 88.
    Surman, O. S., Williams, J., Sheehan, D. V., et al. (1986). Immunological response to stress in agoraphobia and panic attacks. Biological Psychiatry, 21, 768–774.PubMedCrossRefGoogle Scholar
  89. 89.
    Brambilla, F., Bellodi, L., Perna, G., et al. (1992). Psychoimmunoendocrine aspects of panic disorder. Neuropsychobiology, 26, 12–22.PubMedCrossRefGoogle Scholar
  90. 90.
    Andreoil, A., Keller, S. E., Taban, C., et al. (1990). Immune function in major depressive disorder: Relation to panic disorder comorbidity. Biological Psychiatry, 27(suppl. 9A), 95A.Google Scholar
  91. 91.
    Koh, K. B., & Lee, Y. (2004). Reduced anxiety level by therapeutic interventions and cell-mediated immunity in panic disorder patients. Psychotherapy and Psychosomatics, 73, 286–292.PubMedCrossRefGoogle Scholar
  92. 92.
    Ramesh, C., Yeragani, V. K., & Balon, R. (1991). A comparative study of immune status in panic disorder patients and controls. Acta Psychiatrica Scandinavica, 84, 396–397.PubMedCrossRefGoogle Scholar
  93. 93.
    Maes, M., Meltzer, H. Y., & Bosmans, E. (1994). Psychoimmune investigation in obsessive-compulsive disorder: Assays of plasma transferrin, IL-2 and IL-6 receptor, and IL-1β and IL-6 concentrations. Neuropsychobiology, 30, 57–60.PubMedCrossRefGoogle Scholar
  94. 94.
    Ironson, G., Wynings, C., Schneiderman, N., et al. (1997). Posttraumatic stress symptoms, intrusive thoughts, loss, and immune function after Hurricane Andrew. Psychosomatic Medicine, 59, 128–141.PubMedGoogle Scholar
  95. 95.
    Watson, P. B., Muller, H. K., Jones, I. H., et al. (1993). Cell-mediated immunity in combat veterans with post-traumatic stress disorder. The Medical Journal of Australia, 159, 513–516.PubMedGoogle Scholar
  96. 96.
    Schleifer, S. J., Keller, S. E., Scott, B. J., et al. (1989). Familial traumatic injury and immunity. San Francisco, CA: American Psychiatric Association New Research. May (Abstract).Google Scholar
  97. 97.
    Koh, K. B. (1995). The Relationship between stress and natural killer-cell activity in medical college students. Korean Journal of Psychosomatic Medicine, 3, 3–10.Google Scholar
  98. 98.
    Chandrashekara, S., Jayashree, K., Veeranna, H. B., et al. (2007). Effects of anxiety on TNF-α levels during psychological stress. Journal of Psychosomatic Research, 63, 65–69.PubMedCrossRefGoogle Scholar
  99. 99.
    Menaghan, E. G. (1982). Measuring coping effectiveness: A panel analysis of marital problems and coping efforts. Journal of Health and Social Behavior, 23, 220–234.PubMedCrossRefGoogle Scholar
  100. 100.
    Holroyd, K. A., & Lazarus, R. S. (1982). Stress, coping and somatic adaptation. In L. Goldberger & S. Breznitz (Eds.), Handbook of stress: Theoretical and clinical aspects. New York: Free Press.Google Scholar
  101. 101.
    Bohnen, N., Nicolson, N., Sulon, J., et al. (1991). Coping style, trait anxiety and cortisol reactivity during mental stress. Journal of Psychosomatic Research, 35, 141–147.PubMedCrossRefGoogle Scholar
  102. 102.
    Burns, V. E., Carroll, D., Ring, C., et al. (2002). Stress, coping, and hepatitis B antibody status. Psychosomatic Medicine, 64, 287–293.PubMedCrossRefGoogle Scholar
  103. 103.
    Kiecolt-Glaser, J. K., Garner, W., Speicher, C., et al. (1984). Psychosocial modifiers of immunocompetence in medical students. Psychosomatic Medicine, 46, 7–14.PubMedGoogle Scholar
  104. 104.
    Glaser, R., Kiecolt-Glaser, J. K., Bonneau, R., et al. (1992). Stress-induced modulation of the immune response to recombinant hepatitis B vaccine. Psychosomatic Medicine, 54, 22–29.PubMedGoogle Scholar
  105. 105.
    Segerstrom, S. C. (2001). Optimism, goal conflict, and stressor-related immune change. Journal of Behavioral Medicine, 24, 441–467.PubMedCrossRefGoogle Scholar
  106. 106.
    Stowell, J. R., Kiecolt-Glaser, J. K., & Glaser, R. (2001). Perceived stress and cellular immunity: When coping counts. Journal of Behavioral Medicine, 24, 323–339.PubMedCrossRefGoogle Scholar
  107. 107.
    Peavey, B. S., Lawlis, G. F., & Goven, A. (1985). Biofeedback-assisted relaxation: Effects on phagocytic capacity. Biofeedback and Self-Regulation, 10, 33–47.PubMedCrossRefGoogle Scholar
  108. 108.
    Green, R. G., & Green, M. L. (1987). Relaxation increases salivary immunoglobulin A. PsychologicalReports, 61, 623–629.PubMedCrossRefGoogle Scholar
  109. 109.
    Laidlaw, T. M., Booth, R. J., & Large, R. G. (1996). Reduction in skin reactions to histamine after a hypnotic procedure. Psychosomatic Medicine, 58, 242–248.PubMedGoogle Scholar
  110. 110.
    Kabat-Zinn, J., Wheeler, E., Light, T., et al. (1998). Influence of a mindfulness meditation-based stress reduction in patients with moderate to severe psoriasis undergoing phototherapy (UVB) and photochemotherapy (PUVA). Psychosomatic Medicine, 60, 625–632.PubMedGoogle Scholar
  111. 111.
    Koh, K. B., Lee, Y., Beyn, K. M., et al. (2008). Counter-stress effects of relaxation on proinflammatory and anti-inflammatory cytokines. Brain, Behavior, and Immunity, 22, 1130–1137.PubMedCrossRefGoogle Scholar
  112. 112.
    Davidson, R. J., Kabat-zinn, J., Schumacher, J., et al. (2003). Alterations in brain and immune function produced by mindfulness meditation. Psychosomatic Medicine, 65, 564–570.PubMedCrossRefGoogle Scholar
  113. 113.
    Pace, T. W., Negi, L. T., Adame, D. D., et al. (2009). Effect of compassion meditation on neuroendocrine, innate immune and behavioral responses to psychosocial stress. Psychoneuroendocrinology, 34, 87–98.PubMedCrossRefGoogle Scholar
  114. 114.
    Lutgendorf, S. K., Logan, H., Costanzo, E., et al. (2004). Effects of acute stress, relaxation, and a neurogenic inflammatory stimulus on interleukin-6 in humans. Brain, Behavior, and Immunity, 18, 55–64.PubMedCrossRefGoogle Scholar
  115. 115.
    Epel, E. S., Blackburn, E. H., Lin, J., et al. (2004). Accelerated telomere shortening in response to life stress. Proceedings of the National Academy of Sciences of the United States of America, 101, 17312–17315.PubMedCrossRefGoogle Scholar
  116. 116.
    Jacob, T. L., Epel, E. S., Lin, J., et al. (2011). Intensive meditation training, immune cell telomerase activity, and psychological mediators. Psychoneuroendocrinology, 36, 664–681.CrossRefGoogle Scholar
  117. 117.
    Baggett, H. L., Antoni, M. H., & August, S. M. (1990). The effects of frequency of relaxation practice on immune markers in an HIV-1 high risk group. Psychosomatic Medicine, 52, 243.Google Scholar
  118. 118.
    Cruess, S., Antoni, M., Cruess, D., et al. (2000). Reductions in herpes simplex virus type 2 antibody titers after cognitive behavioral stress management and relationships with neuroendocrine function, relaxation skills, and social support in HIV-positive men. Psychosomatic Medicine, 62, 828–837.PubMedGoogle Scholar
  119. 119.
    Taylor, D. N. (1995). Effects of a behavioral stress-management program on anxiety, mood, self-esteem, and T-cell count in HIV positive men. Psychological Reports, 76, 451–457.PubMedCrossRefGoogle Scholar
  120. 120.
    Kiecolt-Glaser, J. K., Glaser, R., & Williger, D. (1985). Psychosocial enhancement of immunocompetence in a geriatric population. Health Psychology, 4, 25–41.PubMedCrossRefGoogle Scholar
  121. 121.
    Andersen, B. L., Golden-Kreutz, D., Emery, C. F., et al. (2007). Distress reduction from a psychological intervention contributes to improved health for cancer patients. Brain, Behavior, and Immunity, 21, 953–961.PubMedCrossRefGoogle Scholar
  122. 122.
    Nunes, D. F., Rodriguez, A. L., da Silva Hoffmann, F., et al. (2007). Relaxation and guided imagery program in patients with breast cancer undergoing radiotherapy is not associated with neuroimmunomodulatory effects. Journal of Psychosomatic Research, 63, 647–655.PubMedCrossRefGoogle Scholar
  123. 123.
    Robinson, F. P., Mathews, H. L., Witek-Janusek, L., et al. (2003). Psycho-endocrine-immune response to mindfulness-based stress reduction in individuals infected with the human immunodeficiency virus: a quasiexperimental study. Journal of Alternative and Complementary Medicine New York, 9, 683–694.CrossRefGoogle Scholar
  124. 124.
    Creswell, J. D., Myers, H. F., Cole, S. W., et al. (2009). Mindfulness meditation training effects on CD4+ T lymphocytes in HIV-1 infected adults: A small randomized controlled trial. Brain, Behavior, and Immunity, 23, 184–188.PubMedCrossRefGoogle Scholar
  125. 125.
    Witek-Janusek, L., Albuquerque, K., Chroniak, K. R., et al. (2008). Effect of mindfulness based stress reduction on immune function, quality of life and coping in women newly diagnosed with early stage breast cancer. Brain, Behavior, and Immunity, 22, 969–981.PubMedCrossRefGoogle Scholar
  126. 126.
    Carlson, L. E., Speca, M., Patel, K. D., et al. (2003). Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress, and immune parameters in breast and prostate cancer outpatients. Psychosomatic Medicine, 65, 571–581.PubMedCrossRefGoogle Scholar
  127. 127.
    Scanga, C. B., Verde, T. J., Paolone, A. M., et al. (1998). Effects of weight loss and exercise training on natural killer cell activity in obese women. Medicine & Science in Sports & Exercise, 30, 1666–1671.CrossRefGoogle Scholar
  128. 128.
    Koh, K. B., & Lew, S. H. (1999). The effect of vitamin B-complex on stress-induced immune alteration. Korean Journal of Psychosomatic Medicine, 7, 196–202.Google Scholar
  129. 129.
    Otto, M. W., Hong, J. J., & Safren, S. A. (2002). Benzodiazepine discontinuation difficulties in panic disorder: Conceptual model and outcome for cognitive behavioral therapy. Current Pharmaceutical Design, 8, 75–80.PubMedCrossRefGoogle Scholar
  130. 130.
    Kampman, M., Keijsers, G. P., Hoogduin, C. A. L., et al. (2002). A randomized, double-blind, placebo-controlled study of the effects of adjunctive paroxetine in panic disorder patients unsuccessfully treated with cognitive-behavioral therapy alone. The Journal of Clinical Psychiatry, 63, 772–777.PubMedCrossRefGoogle Scholar
  131. 131.
    Atanackovic, D., Kroger, H., Serke, S., et al. (2004). Immune parameters in patients with anxiety or depression during psychotherapy. Journal of Affective Disorders, 81, 201–209.PubMedCrossRefGoogle Scholar
  132. 132.
    Irwin, M., Lacher, U., & Caldwell, C. (1992). Depression and reduced natural killer cytotoxicity: A longitudinal study of depressed patients and control subjects. Psychological Medicine, 22, 1045–1050.PubMedCrossRefGoogle Scholar
  133. 133.
    Andersen, B. L., Farrar, W. B., Golden-Kreutz, D. M., et al. (2004). Psychological, behavioral, and immune changes after a psychological intervention: A clinical trial. Journal of Clinical Oncology, 22, 3570–3580.PubMedCrossRefGoogle Scholar
  134. 134.
    Antoni, M. H., Lechner, S., Diaz, A., et al. (2009). Cognitive behavioral stress management effects on psychosocial and physiological adaptation in women undergoing treatment for breast cancer. Brain, Behavior, and Immunity, 23, 580–591.PubMedCrossRefGoogle Scholar
  135. 135.
    van der Pompe, G., Duivenvoorden, H. J., Antoni, M. H., et al. (1997). Effectiveness of a short-term group psychotherapy program on endocrine and immune function in breast cancer patients: An exploratory study. Journal of Psychosomatic Research, 42, 453–466.PubMedCrossRefGoogle Scholar
  136. 136.
    Koh, K. B., Sohn, S.-H., Kang, J. I., et al. (2012). Relationship between neural activity and immunity in patients with undifferentiated somatoform disorder. Psychiatry Research: Neuroimaging, 202, 252–256.PubMedCrossRefGoogle Scholar
  137. 137.
    Dantzer, R. (2005). Somatization: A psychoneuroimmune perspective. Psychoneuroendocrinology, 30, 947–952.PubMedCrossRefGoogle Scholar
  138. 138.
    Daruna, J. H., & Morgan, J. E. (1990). Psychosocial effects on immune function: Neuroendocrine pathways. Psychosomatics, 31, 4–12.PubMedCrossRefGoogle Scholar
  139. 139.
    Liang, S.-W., Jemerin, J. M., Tschann, J. M., et al. (1997). Life events, frontal electroencephalogram laterality, and functional immune status after acute psychological stressors in adolescents. Psychosomatic Medicine, 59, 178–186.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of PsychiatryYonsei University College of MedicineSeodaemun-gu, SeoulKorea

Personalised recommendations