Antibody Mediated Regulation of Humoral Immunity

  • Birgitta Heyman


Antibodies can regulate the antibody response against the antigen they bind to. This phenomenon is called antibody feedback regulation and can be both positive and negative. Passively administered erythrocyte-specific IgG antibodies can completely prevent an antibody response against erythrocytes. This is used clinically in Rhesus prophylaxis. IgM can enhance the antibody response to large antigens and this effect is dependent on the ability of IgM to activate complement. Enhancement by IgG3 is also dependent on complement whereas IgG1, IgG2a, and IgG2b enhance antibody responses to protein antigens via IgG Fc receptors. Finally, IgE is a potent enhancer of both antibody and CD4 T cells responses and this effect is mediated by the low-affinity receptor for IgE, CD23.


Rhesus prophylaxis Feedback regulation CD23 IgM IgE Complement receptor CD21 Fc receptors 


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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Medical Biochemistry and MicrobiologyUppsala UniversityUppsalaSweden

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