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In vitro Production of Secondary Metabolites Using Elicitor in Catharanthus roseus: A Case Study

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Abstract

Secondary metabolites are mainly derived from plants and are used by humans from time immemorial. A plant cell, tissue, and organ culture has an inherent capacity to manufacture valuable chemical compounds as the parent plant does in nature. In vitro plant materials are one of the good sources for the production of secondary metabolite and elicitation can be used as one of the important tool in order to improve the synthesis of these compounds. In a variety of plant cell cultures, elicitors have increased production of terpenoid indole alkaloids, isoflavonoid phytoalexins, serquiterpenoid phytoalexin, coumarins etc. Although elicitation has been carried out in large number of medicinal plants, we extensively studied it in Catharanthus roseus, because it is an important source of anticancer compounds Vinblastine (VLB) and Vincristine (VCR). The use of elicitor is also important in order to meet the market demands, for reducing production costs and for in-depth investigation of biochemical and metabolic pathways. This information helps us in manipulation of biosynthetic pathways which can be used as a powerful tool to make natural product-like compounds.

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Acknowledgements

The first author is thankful to Council of Scientific and Industrial Research (CSIR) for receiving Senior Research Fellowship (SRF).

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Authors and Affiliations

  1. Department of Botany, Zakir Husain Delhi College, University of Delhi, Jawahar Lal Nehru Marg, 110002, New Delhi, India

    Zahid Hameed Siddiqui

  2. Department of Botany, Hamdard University, 110062, New Delhi, India

    Abdul Mujib &  Mahmooduzzafar

  3. Department of Biotechnology, Hamdard University, 110062, New Delhi, India

    Junaid Aslam

  4. Faculty of Forestry, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia

    Khalid Rehman Hakeem

  5. Department of Bioscience, Jamia Millia Islamia, 110025, New Delhi, India

    Talat Parween

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  1. Zahid Hameed Siddiqui
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  2. Abdul Mujib
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  3. Mahmooduzzafar
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  4. Junaid Aslam
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  5. Khalid Rehman Hakeem
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  6. Talat Parween
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Correspondence to Zahid Hameed Siddiqui .

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Editors and Affiliations

  1. , Faculty of Forestry, University Putra Malaysia, Darul Ehsan, Selangor, 43400, Malaysia

    Khalid Rehman Hakeem

  2. A.S. College, Department of Botany, University of Kashmir, Srinagar, 190008, India

    Parvaiz Ahmad

  3. , Faculty of Forestry, Universiti Putra Malaysia, n/a, Selangor, 35100, Malaysia

    Munir Ozturk

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Siddiqui, Z., Mujib, A., Mahmooduzzafar, Aslam, J., Rehman Hakeem, K., Parween, T. (2013). In vitro Production of Secondary Metabolites Using Elicitor in Catharanthus roseus: A Case Study. In: Hakeem, K., Ahmad, P., Ozturk, M. (eds) Crop Improvement. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-7028-1_14

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