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Fibrohistiocytic Lesions

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Atlas of Soft Tissue Tumor Pathology

Part of the book series: Atlas of Anatomic Pathology ((AAP))

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Abstract

The fibrohistiocytic concept was introduced by Stout in the 1960s, based on misinterpreted studies of a heterogeneous group of neoplasms grown in tissue culture. It was considered that some tumors supposedly composed of histiocytes could acquire morphologic and functional properties of fibroblasts. The storiform-pleomorphic malignant fibrous histiocytoma became the most frequently diagnosed sarcoma in all sites in adults, and rarer giant cell and inflammatory, myxoid, and angiomatoid variants were described. However, newer investigative techniques revealed that many such neoplasms might be categorized specifically as pleomorphic rhabdomyosarcomas or liposarcomas, dedifferentiated liposarcomas, melanomas, or poorly differentiated carcinomas. The apparently undifferentiated remainder were not histiocytic but comprised pleomorphic fibroblastic and myofibroblastic cells.

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Authors and Affiliations

  1. Department of Histopathology, The Royal Marsden Hospital, London, UK

    Cyril Fisher MA, MD, DSc, FRCPath

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  1. Cyril Fisher MA, MD, DSc, FRCPath
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Fisher, C. (2013). Fibrohistiocytic Lesions. In: Atlas of Soft Tissue Tumor Pathology. Atlas of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7025-0_5

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  • DOI: https://doi.org/10.1007/978-1-4614-7025-0_5

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7024-3

  • Online ISBN: 978-1-4614-7025-0

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