Skip to main content

Treatment Selection for Superficial Radiotherapy

  • Chapter
  • First Online:
  • 2376 Accesses

Abstract

Superficial radiotherapy is a reasonable nonsurgical approach for the treatment of primary, nonaggressive basal cell carcinoma, and squamous cell carcinoma in patients where surgical intervention is either declined, unadvisable due to comorbidities, or potentially associated with significant functional or cosmetic limitations.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Parkin DM, Muir CS. Cancer incidence in five continents comparability and quality of data. IARC Sci Publ. 1992;120:45–173.

    PubMed  Google Scholar 

  2. MacDonald EJ, Bubendorf E. Some epidemiologic aspects of skin cancer. In: Cumley RW MJ, Aldridge D, et al., editors. Tumors of the skin. St. Louis, MO: Mosby-Year Book; 1964. p. 23–65.

    Google Scholar 

  3. Finizio L, Vidali C, Calacione R, Beorchia A, Trevisan G. What is the current role of radiation therapy in the treatment of skin carcinomas? Tumori. 2002;88(1):48–52.

    PubMed  Google Scholar 

  4. Lovett RD, Perez CA, Shapiro SJ, Garcia DM. External irradiation of epithelial skin cancer. Int J Radiat Oncol Biol Phys. 1990;19(2):235–42.

    Article  PubMed  CAS  Google Scholar 

  5. Schalock PC, Carter J, Zug KA. Use of ionizing radiation in dermatologic training centers. J Am Acad Dermatol. 2006;55(5):912–3.

    Article  PubMed  Google Scholar 

  6. Kingery FA. Radiation therapy in dermatologic training centers. J Am Acad Dermatol. 1986;14(6):1108–10.

    Article  PubMed  CAS  Google Scholar 

  7. Goldschmidt H. Treatment planning: selection of physical factors and radiation techniques. In: Goldschmidt H, Panizzon RG, editors. Modern dermatologic radiation therapy. New York: Springer; 1991.

    Chapter  Google Scholar 

  8. Alam M, Nanda S, Mittal BB, Kim NA, Yoo S. The use of brachytherapy in the treatment of nonmelanoma skin cancer: a review. J Am Acad Dermatol. 2011;65(2):377–88.

    Article  PubMed  Google Scholar 

  9. Cognetta AB, Howard B, Heaton H, Stoddard E, Hong HG, Green WH. Superficial X-ray in the treatment of basal and squamous cell carcinomas: a viable option in select patients. J Am Acad Dermatol. 2012;67(6):1235–41.

    Article  PubMed  Google Scholar 

  10. Rowe DE, Carroll RJ, Day Jr CL. Long-term recurrence rates in previously untreated (primary) basal cell carcinoma: implications for patient follow-up. J Dermatol Surg Oncol. 1989;15(3):315–28.

    PubMed  CAS  Google Scholar 

  11. Rowe DE, Carroll RJ, Day Jr CL. Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip implications for treatment modality selection. J Am Acad Dermatol. 1992;26(6):976–90.

    Article  PubMed  CAS  Google Scholar 

  12. Shore RE, Moseson M, Harley N, Pasternack BS. Tumors and other diseases following childhood x-ray treatment for ringworm of the scalp (Tinea capitis). Health Phys. 2003;85(4):404–8.

    Article  PubMed  CAS  Google Scholar 

  13. Wilder RB, Kittelson JM, Shimm DS. Basal cell carcinoma treated with radiation therapy. Cancer. 1991;68(10):2134–7.

    Article  PubMed  CAS  Google Scholar 

  14. Caccialanza M, Piccinno R, Grammatica A. Radiotherapy of recurrent basal and squamous cell skin carcinomas: a study of 249 re-treated carcinomas in 229 patients. Eur J Dermatol. 2001;11(1):25–8.

    PubMed  CAS  Google Scholar 

  15. Bart RS, Kopf AW, Petratos MA. X-ray therapy of skin cancer: evaluation of a “standardized” method for treating basal-cell epitheliomas. Proc Natl Cancer Conf. 1970;6:559–69.

    PubMed  CAS  Google Scholar 

  16. Bart RS, Kopf AW, Gladstein AH. Treatment of morphea-type basal cell carcinomas with radiation therapy. Arch Dermatol. 1977;113(6):783–6.

    Article  PubMed  CAS  Google Scholar 

  17. Kyrgidis A, Tzellos TG, Kechagias N, Patrikidou A, Xirou P, Kitikidou K, et al. Cutaneous squamous cell carcinoma (SCC) of the head and neck: risk factors of overall and recurrence-free survival. Eur J Cancer. 2010;46(9):1563–72.

    Article  PubMed  Google Scholar 

  18. Jackson JE, Dickie GJ, Wiltshire KL, Keller J, Tripcony L, Poulsen MG, et al. Radiotherapy for perineural invasion in cutaneous head and neck carcinomas: toward a risk-adapted treatment approach. Head Neck. 2009;31(5):604–10.

    Article  PubMed  Google Scholar 

  19. Mendenhall WM, Amdur RJ, Hinerman RW, Cognetta AB, Mendenhall NP. Radiotherapy for cutaneous squamous and basal cell carcinomas of the head and neck. Laryngoscope. 2009;119(10):1994–9.

    Article  PubMed  Google Scholar 

  20. Leibovitch I, Huilgol SC, Selva D, Hill D, Richards S, Paver R. Cutaneous squamous cell carcinoma treated with Mohs micrographic surgery in Australia II. Perineural invasion. J Am Acad Dermatol. 2005;53(2):261–6.

    Article  PubMed  Google Scholar 

  21. Han A, Ratner D. What is the role of adjuvant radiotherapy in the treatment of cutaneous squamous cell carcinoma with perineural invasion? Cancer. 2007;109(6):1053–9.

    Article  PubMed  Google Scholar 

  22. Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5(6):649–55.

    Article  PubMed  CAS  Google Scholar 

  23. Mendenhall WM, Parsons JT, Mendenhall NP, Million RR. T2-T4 carcinoma of the skin of the head and neck treated with radical irradiation. Int J Radiat Oncol Biol Phys. 1987;13(7):975–81.

    Article  PubMed  CAS  Google Scholar 

  24. Friedman DL, Whitton J, Leisenring W, Mertens AC, Hammond S, Stovall M, et al. Subsequent neoplasms in 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2010;102(14):1083–95.

    Article  PubMed  Google Scholar 

  25. Newhauser WD, Durante M. Assessing the risk of second malignancies after modern radiotherapy. Nat Rev Cancer. 2011;11(6):438–48.

    Article  PubMed  CAS  Google Scholar 

  26. Gatti RA. The inherited basis of human radiosensitivity. Acta Oncol. 2001;40(6):702–11.

    Article  PubMed  CAS  Google Scholar 

  27. Kleinerman RA. Radiation-sensitive genetically susceptible pediatric sub-populations. Pediatr Radiol. 2009;39 Suppl 1Suppl 1:S27–31.

    Article  PubMed  Google Scholar 

  28. Veness MJ, Harris D. Role of radiotherapy in the management of organ transplant recipients diagnosed with non-melanoma skin cancers. Australas Radiol. 2007;51(1):12–20.

    Article  PubMed  CAS  Google Scholar 

  29. Mendenhall WM, Amdur RJ, Williams LS, Mancuso AA, Stringer SP, Price MN. Carcinoma of the skin of the head and neck with perineural invasion. Head Neck. 2002;24(1):78–83.

    Article  PubMed  Google Scholar 

  30. Goldberg LH, Kimyai-Asadi A. Diffuse epidermal and periadnexal squamous cell carcinoma in situ: a report of 13 patients. J Am Acad Dermatol. 2005;53(4):623–7.

    Article  PubMed  Google Scholar 

  31. Halpern JN. Radiation therapy in skin cancer. A historical perspective and current applications. Dermatol Surg. 1997;23(11):1089–93.

    Article  PubMed  CAS  Google Scholar 

  32. Shore RE, Albert RE, Reed M, Harley N, Pasternack BS. Skin cancer incidence among children irradiated for ringworm of the scalp. Radiat Res. 1984;100(1):192–204.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Armand B. Cognetta Jr. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this chapter

Cite this chapter

Cognetta, A.B., Wolfe, C.M. (2013). Treatment Selection for Superficial Radiotherapy. In: Cognetta Jr., A., Mendenhall, W. (eds) Radiation Therapy for Skin Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6986-5_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6986-5_8

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6985-8

  • Online ISBN: 978-1-4614-6986-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics