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Introduction to Neuropathology

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Imaging the Brain in Autism

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Abstract

Neuropathology is the study of nervous system tissue in terms of either macro- or microscopic alterations. In this chapter we will concentrate on those microscopic alterations at the cellular (e.g., regressive changes, lipofuscin accumulation) and tissue level (e.g., necrosis) that have been variously claimed to be of relevance to autism. The discussions will draw upon the perspective of the author as to their adequacy for postmortem research. Commentaries by senior investigators will discuss the value of neuropathological studies, especially as compared to other research endeavors.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, University of Louisville, 500 S Preston St Bldg 55A Ste 217, Louisville, KY, 40202, USA

    Manuel F. Casanova M.D.

  2. 151B Beckman Behavioral Laboratories, California Institute of Technology, 1200 East California Blvd., Pasadena, CA, 91125, USA

    Paul H. Patterson Ph.D.

  3. Autism Treatment Research Laboratory, Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 1031-6356, USA

    Eric London Ph.D.

Authors
  1. Manuel F. Casanova M.D.
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  2. Paul H. Patterson Ph.D.
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  3. Eric London Ph.D.
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Correspondence to Manuel F. Casanova M.D. .

Editor information

Editors and Affiliations

  1. , Department of Psychiatry, University of Louisville, S. Preston Street 500, Louisville, 40292, Kentucky, USA

    Manuel F. Casanova

  2. , Department of Bioengineering, University of Louisville, Louisville, 40208, USA

    Ayman S. El-Baz

  3. Global Biomedical Technologies, Otter Glen Ct. 208, Roseville, 95661, California, USA

    Jasjit S. Suri

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Casanova, M.F., Patterson, P.H., London, E. (2013). Introduction to Neuropathology. In: Casanova, M., El-Baz, A., Suri, J. (eds) Imaging the Brain in Autism. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6843-1_1

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