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Male Infertility

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Clinical Reproductive Medicine and Surgery

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Abstract

Abnormalities of the male account for a substantial portion of instances of infertility. Causes encompass genetic, chromosomal, endocrine, anatomic, and vascular disorders, and compromise of spermatogenesis may be due to environmental or nutritional factors as well. Thorough, formal evaluation may identify causes amenable to specific treatment. For instances in which specific treatment is not available or no identifiable cause is found, intrauterine insemination or specific manipulations in assisted reproductive technology offer options for fertility for many men.

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References

  1. Check JH, Chase JS. Improved semen quality after a short-interval second ejaculation. Fertil Steril. 1985;44(3):416–8.

    CAS  Google Scholar 

  2. Hornstein MD, Cohen JN, Thomas PP, Gleason RE, Friedman AJ, Mutter GL. The effect of consecutive day inseminations on semen characteristics in an intrauterine insemination program. Fertil Steril. 1992;58(2):433–5.

    CAS  Google Scholar 

  3. Levitas E, Lunenfeld E, Weiss N, Friger M, Har-Vardi I, Koifman A, et al. Relationship between the duration of sexual abstinence and semen quality: analysis of 9,489 semen samples. Fertil Steril. 2005;83(6):1680–6.

    Google Scholar 

  4. Marshburn PB, Alanis M, Matthews ML, Usadi R, Papadakis MH, Kullstam S, et al. A short period of ejaculatory abstinence before intrauterine insemination is associated with higher pregnancy rates. Fertil Steril. 2010;93(1):286–8.

    Google Scholar 

  5. Tur-Kaspa I, Maor Y, Dor J, Mashiach S. Frequency of intercourse for couples trying to conceive. Lancet. 1994;344(8925):766.

    CAS  Google Scholar 

  6. Peterson BD, Newton CR, Feingold T. Anxiety and sexual stress in men and women undergoing infertility treatment. Fertil Steril. 2007;88(4):911–4.

    Google Scholar 

  7. Saleh RA, Ranga GM, Raina R, Nelson DR, Agarwal A. Sexual dysfunction in men undergoing infertility evaluation: a cohort observational study. Fertil Steril. 2003;79(4):909–12.

    Google Scholar 

  8. Morales A, Buvat J, Gooren LJ, Guay AT, Kaufman JM, Tan HM, et al. Endocrine aspects of sexual dysfunction in men. J Sex Med. 2004;1(1):69–81.

    CAS  Google Scholar 

  9. Wischmann TH. Sexual disorders in infertile couples. J Sex Med. 2010;7(5):1868–76.

    Google Scholar 

  10. Griffith ER, Tomko MA, Timms RJ. Sexual function in spinal cord-injured patients: a review. Arch Phys Med Rehabil. 1973;54(12): 539–43.

    CAS  Google Scholar 

  11. Hendry WF. Disorders of ejaculation: congenital, acquired and functional. Br J Urol. 1998;82(3):331–41.

    CAS  Google Scholar 

  12. Hsiao W, Deveci S, Mulhall JP. Outcomes of the management of post-chemotherapy retroperitoneal lymph node dissection-associated anejaculation. BJU Int. 2012;110(8):1196–200.

    Google Scholar 

  13. Safarinejad MR. Midodrine for the treatment of organic anejaculation but not spinal cord injury: a prospective randomized placebo-controlled double-blind clinical study. Int J Impot Res. 2009;21(4):213–20.

    CAS  Google Scholar 

  14. McGuire C, Manecksha RP, Sheils P, McDermott TE, Grainger R, Flynn R. Electroejaculatory stimulation for male infertility secondary to spinal cord injury: the Irish experience in National Rehabilitation Hospital. Urology. 2011;77(1):83–7.

    Google Scholar 

  15. Schuster TG, Ohl DA. Diagnosis and treatment of ejaculatory dysfunction. Urol Clin North Am. 2002;29(4):939–48.

    Google Scholar 

  16. Sonksen J, Fode M, Lochner-Ernst D, Ohl DA. Vibratory ejaculation in 140 spinal cord injured men and home insemination of their partners. Spinal Cord. 2012;50(1):63–6.

    CAS  Google Scholar 

  17. Steinberger RE, Ohl DA, Bennett CJ, McCabe M, Wang SC. Nifedipine pretreatment for autonomic dysreflexia during electroejaculation. Urology. 1990;36(3):228–31.

    CAS  Google Scholar 

  18. Iremashvili V, Brackett NL, Ibrahim E, Aballa TC, Lynne CM. The choice of assisted ejaculation method is relevant for the diagnosis of azoospermia in men with spinal cord injuries. Spinal Cord. 2011;49(1):55–9.

    CAS  Google Scholar 

  19. Iremashvili VV, Brackett NL, Ibrahim E, Aballa TC, Lynne CM. A minority of men with spinal cord injury have normal semen quality—can we learn from them? A case-control study. Urology. 2010;76(2):347–51.

    Google Scholar 

  20. Momen MN, Fahmy I, Amer M, Arafa M, Zohdy W, Naser TA. Semen parameters in men with spinal cord injury: changes and aetiology. Asian J Androl. 2007;9(5):684–9.

    Google Scholar 

  21. Jorgensen N, Meyts ER, Main KM, Skakkebaek NE. Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesis. Int J Androl. 2010;33(2): 298–303.

    CAS  Google Scholar 

  22. Toppari J, Virtanen HE, Main KM, Skakkebaek NE. Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): environmental connection. Birth Defects Res A Clin Mol Teratol. 2010;88(10):910–9.

    CAS  Google Scholar 

  23. Akre O, Richiardi L. Does a testicular dysgenesis syndrome exist? Hum Reprod. 2009;24(9):2053–60.

    Google Scholar 

  24. Thorup J, McLachlan R, Cortes D, Nation TR, Balic A, Southwell BR, et al. What is new in cryptorchidism and hypospadias—a critical review on the testicular dysgenesis hypothesis. J Pediatr Surg. 2010;45(10):2074–86.

    Google Scholar 

  25. Everaert K, Mahmoud A, Depuydt C, Maeyaert M, Comhaire F. Chronic prostatitis and male accessory gland infection—is there an impact on male infertility (diagnosis and therapy)? Andrologia. 2003;35(5):325–30.

    CAS  Google Scholar 

  26. Menkveld R, Huwe P, Ludwig M, Weidner W. Morphological sperm alternations in different types of prostatitis. Andrologia. 2003;35(5):288–93.

    CAS  Google Scholar 

  27. Menkveld R, Kruger TF. Sperm morphology and male urogenital infections. Andrologia. 1998;30 Suppl 1Suppl 1:49–53.

    Google Scholar 

  28. Jahnukainen K, Heikkinen R, Henriksson M, Cooper TG, Puukko-Viertomies LR, Makitie O. Semen quality and fertility in adult long-term survivors of childhood acute lymphoblastic leukemia. Fertil Steril. 2011;96(4):837–42.

    Google Scholar 

  29. Nurmio M, Keros V, Lahteenmaki P, Salmi T, Kallajoki M, Jahnukainen K. Effect of childhood acute lymphoblastic leukemia therapy on spermatogonia populations and future fertility. J Clin Endocrinol Metab. 2009;94(6):2119–22.

    CAS  Google Scholar 

  30. Pacey AA. Fertility issues in survivors from adolescent cancers. Cancer Treat Rev. 2007;33(7):646–55.

    CAS  Google Scholar 

  31. Green DM, Kawashima T, Stovall M, Leisenring W, Sklar CA, Mertens AC, et al. Fertility of male survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2010;28(2):332–9.

    Google Scholar 

  32. Holoch P, Wald M. Current options for preservation of fertility in the male. Fertil Steril. 2011;96(2):286–90.

    Google Scholar 

  33. Leader A, Lishner M, Michaeli J, Revel A. Fertility considerations and preservation in haemato-oncology patients undergoing treatment. Br J Haematol. 2011;153(3):291–308.

    Google Scholar 

  34. Muthusami KR, Chinnaswamy P. Effect of chronic alcoholism on male fertility hormones and semen quality. Fertil Steril. 2005;84(4):919–24.

    CAS  Google Scholar 

  35. Said TM, Ranga G, Agarwal A. Relationship between semen quality and tobacco chewing in men undergoing infertility evaluation. Fertil Steril. 2005;84(3):649–53.

    Google Scholar 

  36. Soares SR, Melo MA. Cigarette smoking and reproductive function. Curr Opin Obstet Gynecol. 2008;20(3):281–91.

    Google Scholar 

  37. Jensen TK, Hjollund NH, Henriksen TB, Scheike T, Kolstad H, Giwercman A, et al. Does moderate alcohol consumption affect fertility? Follow up study among couples planning first pregnancy. BMJ. 1998;317(7157):505–10.

    CAS  Google Scholar 

  38. Martini AC, Molina RI, Estofan D, Senestrari D, Fiol de Cuneo M, Ruiz RD. Effects of alcohol and cigarette consumption on human seminal quality. Fertil Steril. 2004;82(2):374–7.

    Google Scholar 

  39. Povey AC, Clyma JA, McNamee R, Moore HD, Baillie H, Pacey AA, et al. Modifiable and non-modifiable risk factors for poor semen quality: a case-referent study. Hum Reprod. 2012;27(9):2799–806.

    CAS  Google Scholar 

  40. Fuentes A, Munoz A, Barnhart K, Arguello B, Diaz M, Pommer R. Recent cigarette smoking and assisted reproductive technologies outcome. Fertil Steril. 2010;93(1):89–95.

    CAS  Google Scholar 

  41. Hammoud AO, Gibson M, Peterson CM, Meikle AW, Carrell DT. Impact of male obesity on infertility: a critical review of the current literature. Fertil Steril. 2008;90(4):897–904.

    Google Scholar 

  42. Roth MY, Amory JK, Page ST. Treatment of male infertility ­secondary to morbid obesity. Nat Clin Pract Endocrinol Metab. 2008;4(7):415–9.

    Google Scholar 

  43. Hammoud AO, Carrell DT, Gibson M, Peterson CM, Meikle AW. Updates on the relation of weight excess and reproductive function in men: sleep apnea as a new area of interest. Asian J Androl. 2012;14(1):77–81.

    Google Scholar 

  44. Relwani R, Berger D, Santoro N, Hickmon C, Nihsen M, Zapantis A, et al. Semen parameters are unrelated to BMI but vary with SSRI use and prior urological surgery. Reprod Sci. 2011;18(4):391–7.

    Google Scholar 

  45. Rybar R, Kopecka V, Prinosilova P, Markova P, Rubes J. Male obesity and age in relationship to semen parameters and sperm chromatin integrity. Andrologia. 2011;43(4):286–91.

    CAS  Google Scholar 

  46. Hammoud AO, Griffin J, Meikle AW, Gibson M, Peterson CM, Carrell DT. Association of aromatase (TTTAn) repeat polymorphism length and the relationship between obesity and decreased sperm concentration. Hum Reprod. 2010;25(12):3146–51.

    CAS  Google Scholar 

  47. Hofny ER, Ali ME, Abdel-Hafez HZ, Kamal Eel D, Mohamed EE, Abd El-Azeem HG, et al. Semen parameters and hormonal profile in obese fertile and infertile males. Fertil Steril. 2010;94(2):581–4.

    CAS  Google Scholar 

  48. Sermondade N, Massin N, Boitrelle F, Pfeffer J, Eustache F, Sifer C, et al. Sperm parameters and male fertility after bariatric surgery: three case series. Reprod Biomed Online. 2012;24(2):206–10.

    Google Scholar 

  49. Arce JC, De Souza MJ. Exercise and male factor infertility. Sports Med. 1993;15(3):146–69.

    CAS  Google Scholar 

  50. Gebreegziabher Y, Marcos E, McKinon W, Rogers G. Sperm characteristics of endurance trained cyclists. Int J Sports Med. 2004;25(4):247–51.

    CAS  Google Scholar 

  51. Vaamonde D, Da Silva ME, Poblador MS, Lancho JL. Reproductive profile of physically active men after exhaustive endurance exercise. Int J Sports Med. 2006;27(9):680–9.

    CAS  Google Scholar 

  52. Wu FC, Aitken RJ, Ferguson A. Inflammatory bowel disease and male infertility: effects of sulfasalazine and 5-aminosalicylic acid on sperm-fertilizing capacity and reactive oxygen species generation. Fertil Steril. 1989;52(5):842–5.

    CAS  Google Scholar 

  53. de Souza GL, Hallak J. Anabolic steroids and male infertility: a comprehensive review. BJU Int. 2011;108(11):1860–5.

    Google Scholar 

  54. Lombardo F, Sgro P, Salacone P, Gilio B, Gandini L, Dondero F, et al. Androgens and fertility. J Endocrinol Invest. 2005;28(3 Suppl):51–5.

    CAS  Google Scholar 

  55. Boxmeer JC, Smit M, Utomo E, Romijn JC, Eijkemans MJ, Lindemans J, et al. Low folate in seminal plasma is associated with increased sperm DNA damage. Fertil Steril. 2009;92(2):548–56.

    CAS  Google Scholar 

  56. Colagar AH, Marzony ET, Chaichi MJ. Zinc levels in seminal plasma are associated with sperm quality in fertile and infertile men. Nutr Res. 2009;29(2):82–8.

    CAS  Google Scholar 

  57. Ebisch IM, Thomas CM, Peters WH, Braat DD, Steegers-Theunissen RP. The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Hum Reprod Update. 2007;13(2):163–74.

    CAS  Google Scholar 

  58. Mendiola J, Torres-Cantero AM, Vioque J, Moreno-Grau JM, Ten J, Roca M, et al. A low intake of antioxidant nutrients is associated with poor semen quality in patients attending fertility clinics. Fertil Steril. 2010;93(4):1128–33.

    CAS  Google Scholar 

  59. Mistry HD, Broughton Pipkin F, Redman CW, Poston L. Selenium in reproductive health. Am J Obstet Gynecol. 2012;206(1): 21–30.

    CAS  Google Scholar 

  60. Murphy LE, Mills JL, Molloy AM, Qian C, Carter TC, Strevens H, et al. Folate and vitamin B12 in idiopathic male infertility. Asian J Androl. 2011;13(6):856–61.

    CAS  Google Scholar 

  61. Safarinejad MR, Shafiei N, Safarinejad S. Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase (C677T, A1298C, and G1793A) as risk factors for idiopathic male infertility. Reprod Sci. 2011;18(3):304–15.

    CAS  Google Scholar 

  62. Hawkes WC, Alkan Z, Wong K. Selenium supplementation does not affect testicular selenium status or semen quality in North American men. J Androl. 2009;30(5):525–33.

    CAS  Google Scholar 

  63. Hammoud A, Carrell DT, Gibson M, Sanderson M, Parker-Jones K, Peterson CM. Decreased sperm motility is associated with air pollution in Salt Lake City. Fertil Steril. 2010;93(6):1875–9.

    Google Scholar 

  64. Benoff S, Jacob A, Hurley IR. Male infertility and environmental exposure to lead and cadmium. Hum Reprod Update. 2000;6(2): 107–21.

    CAS  Google Scholar 

  65. Schuurs AH. Reproductive toxicity of occupational mercury. A review of the literature. J Dent. 1999;27(4):249–56.

    CAS  Google Scholar 

  66. Duty SM, Silva MJ, Barr DB, Brock JW, Ryan L, Chen Z, et al. Phthalate exposure and human semen parameters. Epidemiology. 2003;14(3):269–77.

    Google Scholar 

  67. Hauser R, Meeker JD, Duty S, Silva MJ, Calafat AM. Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites. Epidemiology. 2006;17(6): 682–91.

    Google Scholar 

  68. Dalvie MA, Myers JE, Thompson ML, Robins TG, Dyer S, Riebow J, et al. The long-term effects of DDT exposure on semen, fertility, and sexual function of malaria vector-control workers in Limpopo Province, South Africa. Environ Res. 2004;96(1):1–8.

    CAS  Google Scholar 

  69. Hauser R, Chen Z, Pothier L, Ryan L, Altshul L. The relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and p,p′-DDE. Environ Health Perspect. 2003;111(12):1505–11.

    CAS  Google Scholar 

  70. Rozati R, Reddy PP, Reddanna P, Mujtaba R. Xenoesterogens and male infertility: myth or reality? Asian J Androl. 2000;2(4):263–9.

    CAS  Google Scholar 

  71. Hanke W, Jurewicz J. The risk of adverse reproductive and developmental disorders due to occupational pesticide exposure: an overview of current epidemiological evidence. Int J Occup Med Environ Health. 2004;17(2):223–43.

    Google Scholar 

  72. Phillips KP, Tanphaichitr N. Human exposure to endocrine disrupters and semen quality. J Toxicol Environ Health B Crit Rev. 2008;11(3–4):188–220.

    CAS  Google Scholar 

  73. Sadeu JC, Hughes CL, Agarwal S, Foster WG. Alcohol, drugs, caffeine, tobacco, and environmental contaminant exposure: reproductive health consequences and clinical implications. Crit Rev Toxicol. 2010;40(7):633–52.

    CAS  Google Scholar 

  74. Toft G, Rignell-Hydbom A, Tyrkiel E, Shvets M, Giwercman A, Lindh CH, et al. Semen quality and exposure to persistent organochlorine pollutants. Epidemiology. 2006;17(4):450–8.

    Google Scholar 

  75. Kolettis PN, Sandlow JI. Clinical and genetic features of patients with congenital unilateral absence of the vas deferens. Urology. 2002;60(6):1073–6.

    Google Scholar 

  76. Stahl P, Schlegel PN. Standardization and documentation of varicocele evaluation. Curr Opin Urol. 2011;21(6):500–5.

    Google Scholar 

  77. Cocuzza M, Athayde KS, Alvarenga C, Srougi M, Hallak J. Grade 3 varicocele in fertile men: a different entity. J Urol. 2012;187(4): 1363–8.

    Google Scholar 

  78. Li F, Yue H, Yamaguchi K, Okada K, Matsushita K, Ando M, et al. Effect of surgical repair on testosterone production in infertile men with varicocele: a meta-analysis. Int J Urol. 2012;19(2): 149–54.

    CAS  Google Scholar 

  79. Mostafa T, Anis T, El Nashar A, Imam H, Osman I. Seminal plasma reactive oxygen species-antioxidants relationship with varicocele grade. Andrologia. 2012;44(1):66–9.

    CAS  Google Scholar 

  80. Chen SS, Chen LK. Risk factors for progressive deterioration of semen quality in patients with varicocele. Urology. 2012;79(1):128–32.

    Google Scholar 

  81. Cozzolino DJ, Lipshultz LI. Varicocele as a progressive lesion: positive effect of varicocele repair. Hum Reprod Update. 2001;7(1):55–8.

    CAS  Google Scholar 

  82. Mac LJ, Gold RZ. The male factor in fertility and infertility. IV. Sperm morphology in fertile and infertile marriage. Fertil Steril. 1951;2(5):394–414.

    Google Scholar 

  83. Macleod J. Semen quality in 1000 men of known fertility and in 800 cases of infertile marriage. Fertil Steril. 1951;2(2):115–39.

    CAS  Google Scholar 

  84. Macleod J, Gold RZ. The male factor in fertility and infertility. II. Spermatozoon counts in 1000 men of known fertility and in 1000 cases of infertile marriage. J Urol. 1951;66(3):436–49.

    CAS  Google Scholar 

  85. WHO. WHO laboratory manual for the examination and processing of human semen. 5th ed. Geneva: WHO Press; 2010.

    Google Scholar 

  86. Cooper TG, Noonan E, von Eckardstein S, Auger J, Baker HW, Behre HM, et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update. 2010;16(3): 231–45.

    Google Scholar 

  87. Guzick DS, Overstreet JW, Factor-Litvak P, Brazil CK, Nakajima ST, Coutifaris C, et al. Sperm morphology, motility, and concentration in fertile and infertile men. N Engl J Med. 2001;345(19): 1388–93.

    CAS  Google Scholar 

  88. Mallidis C, Howard EJ, Baker HW. Variation of semen quality in normal men. Int J Androl. 1991;14(2):99–107.

    CAS  Google Scholar 

  89. Hammoud AO, Gibson M, Peterson MC, Carrell DT. Effect of sperm preparation techniques by density gradient on intra-individual variation of sperm motility. Arch Androl. 2007;53(6):349–51.

    Google Scholar 

  90. Bonde JP, Ernst E, Jensen TK, Hjollund NH, Kolstad H, Henriksen TB, et al. Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners. Lancet. 1998;352(9135):1172–7.

    CAS  Google Scholar 

  91. Ho LM, Lim AS, Lim TH, Hum SC, Yu SL, Kruger TF. Correlation between semen parameters and the Hamster Egg Penetration Test (HEPT) among fertile and subfertile men in Singapore. J Androl. 2007;28(1):158–63.

    Google Scholar 

  92. Menkveld R. Clinical significance of the low normal sperm morphology value as proposed in the fifth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen. Asian J Androl. 2010;12(1):47–58.

    Google Scholar 

  93. Slama R, Eustache F, Ducot B, Jensen TK, Jorgensen N, Horte A, et al. Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities. Hum Reprod. 2002;17(2):503–15.

    CAS  Google Scholar 

  94. Bjorndahl L. What is normal semen quality? On the use and abuse of reference limits for the interpretation of semen analysis results. Hum Fertil (Camb). 2011;14(3):179–86.

    Google Scholar 

  95. De Jonge C. Semen analysis: looking for an upgrade in class. Fertil Steril. 2012;97(2):260–6.

    Google Scholar 

  96. Eliasson R. Semen analysis with regard to sperm number, sperm morphology and functional aspects. Asian J Androl. 2010;12(1):26–32.

    Google Scholar 

  97. Esteves SC, Zini A, Aziz N, Alvarez JG, Sabanegh ES, Agarwal A. Critical appraisal of World Health Organization’s new reference values for human semen characteristics and effect on diagnosis and treatment of subfertile men. Urology. 2012;79:16–22.

    Google Scholar 

  98. Franken DR, Oehninger S. Semen analysis and sperm function testing. Asian J Androl. 2012;14(1):6–13.

    Google Scholar 

  99. Menkveld R, Stander FS, Kotze TJ, Kruger TF, van Zyl JA. The evaluation of morphological characteristics of human spermatozoa according to stricter criteria. Hum Reprod. 1990;5(5):586–92.

    CAS  Google Scholar 

  100. Guven S, Gunalp GS, Tekin Y. Factors influencing pregnancy rates in intrauterine insemination cycles. J Reprod Med. 2008;53(4):257–65.

    Google Scholar 

  101. Kruger TF, Coetzee K. The role of sperm morphology in assisted reproduction. Hum Reprod Update. 1999;5(2):172–8.

    CAS  Google Scholar 

  102. Kruger TF, Swanson RJ, Hamilton M, Simmons KF, Acosta AA, Matta JF, et al. Abnormal sperm morphology and other semen parameters related to the outcome of the hamster oocyte human sperm penetration assay. Int J Androl. 1988;11(2):107–13.

    CAS  Google Scholar 

  103. Morelli SS, Seungdamrong A, McCulloh DH, McGovern PG. Abnormal sperm count and motility on semen analysis are not sufficiently predictive of abnormal Kruger morphology. Fertil Steril. 2010;94(7):2882–4.

    Google Scholar 

  104. Van Waart J, Kruger TF, Lombard CJ, Ombelet W. Predictive value of normal sperm morphology in intrauterine insemination (IUI): a structured literature review. Hum Reprod Update. 2001;7(5):495–500.

    Google Scholar 

  105. Esterhuizen AD, Franken DR, Lourens JG, van Rooyen LH. Clinical importance of zona pellucida-induced acrosome reaction and its predictive value for IVF. Hum Reprod. 2001;16(1):138–44.

    CAS  Google Scholar 

  106. Menkveld R, Rhemrev JP, Franken DR, Vermeiden JP, Kruger TF. Acrosomal morphology as a novel criterion for male fertility diagnosis: relation with acrosin activity, morphology (strict criteria), and fertilization in vitro. Fertil Steril. 1996;65(3):637–44.

    CAS  Google Scholar 

  107. Oehninger S, Acosta AA, Veeck LL, Brzyski R, Kruger TF, Muasher SJ, et al. Recurrent failure of in vitro fertilization: role of the hemizona assay in the sequential diagnosis of specific sperm-oocyte defects. Am J Obstet Gynecol. 1991;164(5 Pt 1):1210–5.

    CAS  Google Scholar 

  108. Bastiaan HS, Windt ML, Menkveld R, Kruger TF, Oehninger S, Franken DR. Relationship between zona pellucida-induced acrosome reaction, sperm morphology, sperm-zona pellucida binding, and in vitro fertilization. Fertil Steril. 2003;79(1):49–55.

    Google Scholar 

  109. Zahalsky MP, Zoltan E, Medley N, Nagler HM. Morphology and the sperm penetration assay. Fertil Steril. 2003;79(1):39–41.

    Google Scholar 

  110. Natali A, Turek PJ. An assessment of new sperm tests for male infertility. Urology. 2011;77(5):1027–34.

    Google Scholar 

  111. Evenson DP, Jost LK, Marshall D, Zinaman MJ, Clegg E, Purvis K, et al. Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic. Hum Reprod. 1999;14(4):1039–49.

    CAS  Google Scholar 

  112. Muratori M, Tamburrino L, Marchiani S, Guido C, Forti G, Baldi E. Critical aspects of detection of sperm DNA fragmentation by TUNEL/flow cytometry. Syst Biol Reprod Med. 2010;56(4):277–85.

    CAS  Google Scholar 

  113. Tamburrino L, Marchiani S, Montoya M, Elia Marino F, Natali I, Cambi M, et al. Mechanisms and clinical correlates of sperm DNA damage. Asian J Androl. 2012;14(1):24–31.

    CAS  Google Scholar 

  114. Bungum M, Humaidan P, Spano M, Jepson K, Bungum L, Giwercman A. The predictive value of sperm chromatin structure assay (SCSA) parameters for the outcome of intrauterine insemination, IVF and ICSI. Hum Reprod. 2004;19(6):1401–8.

    CAS  Google Scholar 

  115. Irvine DS, Twigg JP, Gordon EL, Fulton N, Milne PA, Aitken RJ. DNA integrity in human spermatozoa: relationships with semen quality. J Androl. 2000;21(1):33–44.

    CAS  Google Scholar 

  116. Virro MR, Larson-Cook KL, Evenson DP. Sperm chromatin structure assay (SCSA) parameters are related to fertilization, blastocyst development, and ongoing pregnancy in in vitro fertilization and intracytoplasmic sperm injection cycles. Fertil Steril. 2004;81(5):1289–95.

    Google Scholar 

  117. Werthman P, Wixon R, Kasperson K, Evenson DP. Significant decrease in sperm deoxyribonucleic acid fragmentation after varicocelectomy. Fertil Steril. 2008;90(5):1800–4.

    Google Scholar 

  118. Alvarez JG, Sharma RK, Ollero M, Saleh RA, Lopez MC, Thomas Jr AJ, et al. Increased DNA damage in sperm from leukocytospermic semen samples as determined by the sperm chromatin structure assay. Fertil Steril. 2002;78(2):319–29.

    Google Scholar 

  119. Evenson DP, Wixon R. Environmental toxicants cause sperm DNA fragmentation as detected by the Sperm Chromatin Structure Assay (SCSA). Toxicol Appl Pharmacol. 2005;207(2 Suppl):532–7.

    Google Scholar 

  120. Silver EW, Eskenazi B, Evenson DP, Block G, Young S, Wyrobek AJ. Effect of antioxidant intake on sperm chromatin stability in healthy nonsmoking men. J Androl. 2005;26(4):550–6.

    CAS  Google Scholar 

  121. Tanrikut C, Feldman AS, Altemus M, Paduch DA, Schlegel PN. Adverse effect of paroxetine on sperm. Fertil Steril. 2010;94(3): 1021–6.

    CAS  Google Scholar 

  122. Barratt CL, De Jonge CJ. Clinical relevance of sperm DNA assessment: an update. Fertil Steril. 2010;94(6):1958–9.

    Google Scholar 

  123. Henkel R, Hoogendijk CF, Bouic PJ, Kruger TF. TUNEL assay and SCSA determine different aspects of sperm DNA damage. Andrologia. 2010;42(5):305–13.

    Google Scholar 

  124. Carrell DT. Epigenetics of the male gamete. Fertil Steril. 2012;97(2):267–74.

    CAS  Google Scholar 

  125. Hammoud SS, Nix DA, Hammoud AO, Gibson M, Cairns BR, Carrell DT. Genome-wide analysis identifies changes in histone retention and epigenetic modifications at developmental and imprinted gene loci in the sperm of infertile men. Hum Reprod. 2011;26(9):2558–69.

    CAS  Google Scholar 

  126. Jenkins T, Carrell DT. The sperm epigenome and potential implications for the developing embryo. Reprod. 2011;143(6):727–34.

    Google Scholar 

  127. Navarro-Costa P, Nogueira P, Carvalho M, Leal F, Cordeiro I, Calhaz-Jorge C, et al. Incorrect DNA methylation of the DAZL promoter CpG island associates with defective human sperm. Hum Reprod. 2010;25(10):2647–54.

    CAS  Google Scholar 

  128. Cookson MS, Witt MA, Kimball KT, Grantmyre JE, Lipshultz LI. Can semen analysis predict the presence of antisperm antibodies in patients with primary infertility? World J Urol. 1995;13(5): 318–22.

    CAS  Google Scholar 

  129. Menkveld R, Kruger TF, Kotze TJ, Windt ML, Pretorius E. Detection of sperm antibodies on unwashed spermatozoa with the immunobead test: a comparison of results with the routine method and seminal plasma TAT titers and SCMC test. Am J Reprod Immunol. 1991;25(2):88–91.

    CAS  Google Scholar 

  130. Pretorius E, Windt ML, Menkveld R, Kruger T. Evaluation of immunobead test (IBT), tray-agglutination test (TAT), and sperm immobilization test (SIT). Arch Androl. 1988;20(2):159–62.

    CAS  Google Scholar 

  131. Bohring C, Krause W. Differences in the antigen pattern recognized by antisperm antibodies in patients with infertility and vasectomy. J Urol. 2001;166(3):1178–80.

    CAS  Google Scholar 

  132. Shibahara H, Tsunoda T, Taneichi A, Hirano Y, Ohno A, Takamizawa S, et al. Diversity of antisperm antibodies bound to sperm surface in male immunological infertility. Am J Reprod Immunol. 2002;47(3):146–50.

    Google Scholar 

  133. Ombelet W, Vandeput H, Janssen M, Cox A, Vossen C, Pollet H, et al. Treatment of male infertility due to sperm surface antibodies: IUI or IVF? Hum Reprod. 1997;12(6):1165–70.

    CAS  Google Scholar 

  134. Windt ML, Menkveld R, Kruger TF, van der Merwe JP, Lombard CJ. Effect of rapid dilution of semen on sperm-bound autoantibodies. Arch Androl. 1989;22(3):227–31.

    CAS  Google Scholar 

  135. Franken D, Windt ML, Oosthuizen T, Kruger T, Menkveld R, Coddington C, et al. Assisted reproductive technologies may obviate apparent immunologic infertility. Andrologia. 1991;23(4): 291–5.

    CAS  Google Scholar 

  136. Tasdemir I, Tasdemir M, Fukuda J, Kodama H, Matsui T, Tanaka T. Sperm immobilization antibodies in infertile male sera decrease the acrosome reaction: a possible mechanism for immunologic infertility. J Assist Reprod Genet. 1996;13(5):413–6.

    CAS  Google Scholar 

  137. Eliasson R, Mossberg B, Camner P, Afzelius BA. The immotile-cilia syndrome. A congenital ciliary abnormality as an etiologic factor in chronic airway infections and male sterility. N Engl J Med. 1977;297(1):1–6.

    CAS  Google Scholar 

  138. Lungarella G, Fonzi L, Burrini AG. Ultrastructural abnormalities in respiratory cilia and sperm tails in a patient with Kartagener’s syndrome. Ultrastruct Pathol. 1982;3(4):319–23.

    CAS  Google Scholar 

  139. Sturgess JM, Chao J, Wong J, Aspin N, Turner JA. Cilia with defective radial spokes: a cause of human respiratory disease. N Engl J Med. 1979;300(2):53–6.

    CAS  Google Scholar 

  140. Matsumoto Y, Goto S, Hashimoto H, Kokeguchi S, Shiotani M, Okada H. A healthy birth after intracytoplasmic sperm injection using ejaculated spermatozoa from a patient with Kartagener’s syndrome. Fertil Steril. 2010;93(6):2074.e17–9.

    Google Scholar 

  141. von Zumbusch A, Fiedler K, Mayerhofer A, Jessberger B, Ring J, Vogt HJ. Birth of healthy children after intracytoplasmic sperm injection in two couples with male Kartagener’s syndrome. Fertil Steril. 1998;70(4):643–6.

    Google Scholar 

  142. Ochsenkuhn R, Kamischke A, Nieschlag E. Imipramine for successful treatment of retrograde ejaculation caused by retroperitoneal surgery. Int J Androl. 1999;22(3):173–7.

    CAS  Google Scholar 

  143. Tomasi PA, Fanciulli G, Delitala G. Successful treatment of retrograde ejaculation with the alpha1-adrenergic agonist methoxamine: case study. Int J Impot Res. 2005;17(3):297–9.

    CAS  Google Scholar 

  144. Gerris J, Van Royen E, Mangel-Schots K, Joostens M, de Vits A. Pregnancy after intracytoplasmic sperm injection of metaphase II oocytes with spermatozoa from a man with complete retrograde ejaculation. Hum Reprod. 1994;9(7):1293–6.

    CAS  Google Scholar 

  145. Nikolettos N, Al-Hasani S, Baukloh V, Schopper B, Demirel LC, Baban N, et al. The outcome of intracytoplasmic sperm injection in patients with retrograde ejaculation. Hum Reprod. 1999;14(9):2293–6.

    CAS  Google Scholar 

  146. Yavetz H, Yogev L, Hauser R, Lessing JB, Paz G, Homonnai ZT. Retrograde ejaculation. Hum Reprod. 1994;9(3):381–6.

    CAS  Google Scholar 

  147. Cavallini G. Male idiopathic oligoasthenoteratozoospermia. Asian J Androl. 2006;8(2):143–57.

    CAS  Google Scholar 

  148. Calogero AE, De Palma A, Grazioso C, Barone N, Burrello N, Palermo I, et al. High sperm aneuploidy rate in unselected infertile patients and its relationship with intracytoplasmic sperm injection outcome. Hum Reprod. 2001;16(7):1433–9.

    CAS  Google Scholar 

  149. Cavallini G, Crippa A, Magli MC, Cavallini N, Ferraretti AP, Gianaroli L. A study to sustain the hypothesis of the multiple genesis of oligoasthenoteratospermia in human idiopathic infertile males. Biol Reprod. 2008;79(4):667–73.

    CAS  Google Scholar 

  150. Bernardini L, Gianaroli L, Fortini D, Conte N, Magli C, Cavani S, et al. Frequency of hyper-, hypohaploidy and diploidy in ejaculate, epididymal and testicular germ cells of infertile patients. Hum Reprod. 2000;15(10):2165–72.

    CAS  Google Scholar 

  151. Gianaroli L, Magli MC, Cavallini G, Crippa A, Nadalini M, Bernardini L, et al. Frequency of aneuploidy in sperm from patients with extremely severe male factor infertility. Hum Reprod. 2005;20(8):2140–52.

    Google Scholar 

  152. Ushijima C, Kumasako Y, Kihaile PE, Hirotsuru K, Utsunomiya T. Analysis of chromosomal abnormalities in human spermatozoa using multi-colour fluorescence in-situ hybridization. Hum Reprod. 2000;15(5):1107–11.

    Google Scholar 

  153. Burrello N, Arcidiacono G, Vicari E, Asero P, Di Benedetto D, De Palma A, et al. Morphologically normal spermatozoa of patients with secretory oligo-astheno-teratozoospermia have an increased aneuploidy rate. Hum Reprod. 2004;19(10):2298–302.

    Google Scholar 

  154. Magli MC, Gianaroli L, Ferraretti AP, Gordts S, Fredericks V, Crippa A. Paternal contribution to aneuploidy in preimplantation embryos. Reprod Biomed Online. 2009;18(4):536–42.

    CAS  Google Scholar 

  155. Boissonnas CC, Abdalaoui HE, Haelewyn V, Fauque P, Dupont JM, Gut I, et al. Specific epigenetic alterations of IGF2-H19 locus in spermatozoa from infertile men. Eur J Hum Genet. 2010;18(1):73–80.

    Google Scholar 

  156. Liu CH, Tsao HM, Cheng TC, Wu HM, Huang CC, Chen CI, et al. DNA fragmentation, mitochondrial dysfunction and chromosomal aneuploidy in the spermatozoa of oligoasthenoteratozoospermic males. J Assist Reprod Genet. 2004;21(4):119–26.

    CAS  Google Scholar 

  157. Ramos L, van der Heijden GW, Derijck A, Berden JH, Kremer JA, van der Vlag J, et al. Incomplete nuclear transformation of human spermatozoa in oligo-astheno-teratospermia: characterization by indirect immunofluorescence of chromatin and thiol status. Hum Reprod. 2008;23(2):259–70.

    CAS  Google Scholar 

  158. Schlegel PN, Goldstein M. Alternate indications for varicocele repair: non-obstructive azoospermia, pain, androgen deficiency and progressive testicular dysfunction. Fertil Steril. 2011;96(6): 1288–93.

    Google Scholar 

  159. Abdel-Meguid TA. Predictors of sperm recovery and azoospermia relapse in men with nonobstructive azoospermia after varicocele repair. J Urol. 2012;187(1):222–6.

    Google Scholar 

  160. Baazeem A, Belzile E, Ciampi A, Dohle G, Jarvi K, Salonia A, et al. Varicocele and male factor infertility treatment: a new meta-analysis and review of the role of varicocele repair. Eur Urol. 2011;60(4):796–808.

    Google Scholar 

  161. Williams DH, Karpman E, Lipshultz LI. Varicocele: surgical techniques in 2005. Can J Urol. 2006;13 Suppl 1Suppl 1:13–7.

    Google Scholar 

  162. Evers JH, Collins J, Clarke J. Surgery or embolisation for varicoceles in subfertile men. Cochrane Database Syst Rev. 2008;(3): CD000479.

    Google Scholar 

  163. Ficarra V, Cerruto MA, Liguori G, Mazzoni G, Minucci S, Tracia A, et al. Treatment of varicocele in subfertile men: the Cochrane Review—a contrary opinion. Eur Urol. 2006;49(2):258–63.

    Google Scholar 

  164. Miyaoka R, Esteves SC. A critical appraisal on the role of varicocele in male infertility. Adv Urol. 2012;2012:597495.

    Google Scholar 

  165. Schlegel PN. Is assisted reproduction the optimal treatment for varicocele-associated male infertility? A cost-effectiveness analysis. Urology. 1997;49(1):83–90.

    CAS  Google Scholar 

  166. Oates R. Evaluation of the azoospermic male. Asian J Androl. 2012;14(1):82–7.

    Google Scholar 

  167. Skakkebaek NE, Rajpert-De Meyts E, Main KM. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod. 2001;16(5):972–8.

    CAS  Google Scholar 

  168. Chen SC, Hsieh JT, Yu HJ, Chang HC. Appropriate cut-off value for follicle-stimulating hormone in azoospermia to predict spermatogenesis. Reprod Biol Endocrinol. 2010;8:108.

    Google Scholar 

  169. Bonomi M, Libri DV, Guizzardi F, Guarducci E, Maiolo E, Pignatti E, et al. New understandings of the genetic basis of isolated idiopathic central hypogonadism. Asian J Androl. 2012;14(1):49–56.

    CAS  Google Scholar 

  170. Colao A, Vitale G, Cappabianca P, Briganti F, Ciccarelli A, De Rosa M, et al. Outcome of cabergoline treatment in men with prolactinoma: effects of a 24-month treatment on prolactin levels, tumor mass, recovery of pituitary function, and semen analysis. J Clin Endocrinol Metab. 2004;89(4):1704–11.

    CAS  Google Scholar 

  171. Shimon I, Benbassat C, Hadani M. Effectiveness of long-term cabergoline treatment for giant prolactinoma: study of 12 men. Eur J Endocrinol. 2007;156(2):225–31.

    CAS  Google Scholar 

  172. Cruger DG, Agerholm I, Byriel L, Fedder J, Bruun-Petersen G. Genetic analysis of males from intracytoplasmic sperm injection couples. Clin Genet. 2003;64(3):198–203.

    CAS  Google Scholar 

  173. Foresta C, Garolla A, Bartoloni L, Bettella A, Ferlin A. Genetic abnormalities among severely oligospermic men who are candidates for intracytoplasmic sperm injection. J Clin Endocrinol Metab. 2005;90(1):152–6.

    CAS  Google Scholar 

  174. Harton GL, Tempest HG. Chromosomal disorders and male infertility. Asian J Androl. 2012;14(1):32–9.

    Google Scholar 

  175. Yoshida A, Miura K, Shirai M. Cytogenetic survey of 1,007 infertile males. Urol Int. 1997;58(3):166–76.

    CAS  Google Scholar 

  176. Van Assche E, Bonduelle M, Tournaye H, Joris H, Verheyen G, Devroey P, et al. Cytogenetics of infertile men. Hum Reprod. 1996;11 Suppl 4:1–24; discussion 25–6.

    Google Scholar 

  177. Morris JK, Alberman E, Scott C, Jacobs P. Is the prevalence of Klinefelter syndrome increasing? Eur J Hum Genet. 2008;16(2): 163–70.

    CAS  Google Scholar 

  178. Ishikawa T. Surgical recovery of sperm in non-obstructive azoospermia. Asian J Androl. 2012;14(1):109–15.

    Google Scholar 

  179. Ramasamy R, Ricci JA, Leung RA, Schlegel PN. Successful repeat microdissection testicular sperm extraction in men with nonobstructive azoospermia. J Urol. 2011;185(3):1027–31.

    Google Scholar 

  180. Schlegel PN. Testicular sperm extraction: microdissection improves sperm yield with minimal tissue excision. Hum Reprod. 1999;14(1):131–5.

    CAS  Google Scholar 

  181. Lee JY, Dada R, Sabanegh E, Carpi A, Agarwal A. Role of genetics in azoospermia. Urology. 2011;77(3):598–601.

    Google Scholar 

  182. Martin RH. Cytogenetic determinants of male fertility. Hum Reprod Update. 2008;14(4):379–90.

    CAS  Google Scholar 

  183. Perrin A, Douet-Guilbert N, Le Bris MJ, Keromnes G, Langlois ML, Barriere P, et al. Segregation of chromosomes in sperm of a t(X;18)(q11;p11.1) carrier inherited from his mother: case report. Hum Reprod. 2008;23(1):227–30.

    CAS  Google Scholar 

  184. Harper JC, Coonen E, De Rycke M, Harton G, Moutou C, Pehlivan T, et al. ESHRE PGD Consortium data collection X: cycles from January to December 2007 with pregnancy follow-up to October 2008. Hum Reprod. 2010;25(11):2685–707.

    CAS  Google Scholar 

  185. Fischer J, Colls P, Escudero T, Munne S. Preimplantation genetic diagnosis (PGD) improves pregnancy outcome for translocation carriers with a history of recurrent losses. Fertil Steril. 2010;94(1):283–9.

    Google Scholar 

  186. Massart A, Lissens W, Tournaye H, Stouffs K. Genetic causes of spermatogenic failure. Asian J Androl. 2012;14(1):40–8.

    CAS  Google Scholar 

  187. Stouffs K, Vandermaelen D, Massart A, Menten B, Vergult S, Tournaye H, et al. Array comparative genomic hybridization in male infertility. Hum Reprod. 2012;27(3):921–9.

    CAS  Google Scholar 

  188. McLachlan RI, O’Bryan MK. Clinical Review#: state of the art for genetic testing of infertile men. J Clin Endocrinol Metab. 2010;95(3):1013–24.

    CAS  Google Scholar 

  189. Ferlin A, Vinanzi C, Garolla A, Selice R, Zuccarello D, Cazzadore C, et al. Male infertility and androgen receptor gene mutations: clinical features and identification of seven novel mutations. Clin Endocrinol. 2006;65(5):606–10.

    CAS  Google Scholar 

  190. Gottlieb B, Lombroso R, Beitel LK, Trifiro MA. Molecular pathology of the androgen receptor in male (in)fertility. Reprod Biomed Online. 2005;10(1):42–8.

    CAS  Google Scholar 

  191. Zuccarello D, Ferlin A, Vinanzi C, Prana E, Garolla A, Callewaert L, et al. Detailed functional studies on androgen receptor mild mutations demonstrate their association with male infertility. Clin Endocrinol. 2008;68(4):580–8.

    CAS  Google Scholar 

  192. Griffin DK, Hyland P, Tempest HG, Homa ST. Safety issues in assisted reproduction technology: should men undergoing ICSI be screened for chromosome abnormalities in their sperm? Hum Reprod. 2003;18(2):229–35.

    CAS  Google Scholar 

  193. Sheynkin YR, Hendin BN, Schlegel PN, Goldstein M. Microsurgical repair of iatrogenic injury to the vas deferens. J Urol. 1998;159(1):139–41.

    CAS  Google Scholar 

  194. Tanrikut C, Goldstein M. Obstructive azoospermia: a microsurgical success story. Semin Reprod Med. 2009;27(2):159–64.

    Google Scholar 

  195. Vernaeve V, Festre V, Baetens P, Devroey P, Van Steirteghem A, Tournaye H. Reproductive decisions by couples undergoing artificial insemination with donor sperm for severe male infertility: implications for medical counselling. Int J Androl. 2005;28(1):22–6.

    CAS  Google Scholar 

  196. Gat Y, Bachar GN, Everaert K, Levinger U, Gornish M. Induction of spermatogenesis in azoospermic men after internal spermatic vein embolization for the treatment of varicocele. Hum Reprod. 2005;20(4):1013–7.

    Google Scholar 

  197. Pasqualotto FF, Lucon AM, Hallak J, Goes PM, Saldanha LB, Arap S. Induction of spermatogenesis in azoospermic men after varicocele repair. Hum Reprod. 2003;18(1):108–12.

    Google Scholar 

  198. Santoro N, Filicori M, Crowley Jr WF. Hypogonadotropic disorders in men and women: diagnosis and therapy with pulsatile gonadotropin-releasing hormone. Endocr Rev. 1986;7(1):11–23.

    CAS  Google Scholar 

  199. Bouloux PM, Nieschlag E, Burger HG, Skakkebaek NE, Wu FC, Handelsman DJ, et al. Induction of spermatogenesis by recombinant follicle-stimulating hormone (puregon) in hypogonadotropic azoospermic men who failed to respond to human chorionic gonadotropin alone. J Androl. 2003;24(4):604–11.

    CAS  Google Scholar 

  200. Liu PY, Baker HW, Jayadev V, Zacharin M, Conway AJ, Handelsman DJ. Induction of spermatogenesis and fertility during gonadotropin treatment of gonadotropin-deficient infertile men: predictors of fertility outcome. J Clin Endocrinol Metab. 2009; 94(3):801–8.

    CAS  Google Scholar 

  201. Sinisi AA, Esposito D, Bellastella G, Maione L, Palumbo V, Gandini L, et al. Efficacy of recombinant human follicle stimulating hormone at low doses in inducing spermatogenesis and fertility in hypogonadotropic hypogonadism. J Endocrinol Invest. 2010;33(9):618–23.

    CAS  Google Scholar 

  202. Qu X, Wang M, Wang G, Han T, Mou C, Han L, et al. Surgical outcomes and prognostic factors of transsphenoidal surgery for prolactinoma in men: a single-center experience with 87 consecutive cases. Eur J Endocrinol. 2011;164(4):499–504.

    CAS  Google Scholar 

  203. Berezin M, Shimon I, Hadani M. Prolactinoma in 53 men: clinical characteristics and modes of treatment (male prolactinoma). J Endocrinol Invest. 1995;18(6):436–41.

    CAS  Google Scholar 

  204. Ko EY, Siddiqi K, Brannigan RE, Sabanegh Jr ES. Empirical medical therapy for idiopathic male infertility: a survey of the American Urological Association. J Urol. 2012;187(3):973–8.

    Google Scholar 

  205. Adamopoulos DA. Medical treatment of idiopathic oligozoospermia and male factor subfertility. Asian J Androl. 2000;2(1): 25–32.

    CAS  Google Scholar 

  206. Attia AM, Al-Inany HG, Farquhar C, Proctor M. Gonadotrophins for idiopathic male factor subfertility. Cochrane Database Syst Rev. 2007;(4):CD005071.

    Google Scholar 

  207. Comhaire F. Clinical andrology: from evidence-base to ethics. The ‘E’ quintet in clinical andrology. Hum Reprod. 2000;15(10):2067–71.

    CAS  Google Scholar 

  208. Ghanem H, Shaeer O, El-Segini A. Combination clomiphene citrate and antioxidant therapy for idiopathic male infertility: a randomized controlled trial. Fertil Steril. 2010;93(7):2232–5.

    CAS  Google Scholar 

  209. Krause W, Holland-Moritz H, Schramm P. Treatment of idiopathic oligozoospermia with tamoxifen—a randomized controlled study. Int J Androl. 1992;15(1):14–8.

    CAS  Google Scholar 

  210. Moradi M, Moradi A, Alemi M, Ahmadnia H, Abdi H, Ahmadi A, et al. Safety and efficacy of clomiphene citrate and L-carnitine in idiopathic male infertility: a comparative study. Urol J. 2010;7(3): 188–93.

    Google Scholar 

  211. Pavlovich CP, King P, Goldstein M, Schlegel PN. Evidence of a treatable endocrinopathy in infertile men. J Urol. 2001;165(3): 837–41.

    CAS  Google Scholar 

  212. Raman JD, Schlegel PN. Aromatase inhibitors for male infertility. J Urol. 2002;167(2 Pt 1):624–9.

    CAS  Google Scholar 

  213. Wong WY, Merkus HM, Thomas CM, Menkveld R, Zielhuis GA, Steegers-Theunissen RP. Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial. Fertil Steril. 2002;77(3):491–8.

    Google Scholar 

  214. Comhaire FH, El Garem Y, Mahmoud A, Eertmans F, Schoonjans F. Combined conventional/antioxidant “Astaxanthin” treatment for male infertility: a double blind, randomized trial. Asian J Androl. 2005;7(3):257–62.

    CAS  Google Scholar 

  215. Cavallini G, Ferraretti AP, Gianaroli L, Biagiotti G, Vitali G. Cinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermia. J Androl. 2004;25(5):761–70; discussion 71–2.

    Google Scholar 

  216. Lenzi A, Sgro P, Salacone P, Paoli D, Gilio B, Lombardo F, et al. A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia. Fertil Steril. 2004;81(6):1578–84.

    CAS  Google Scholar 

  217. Kumar R, Gautam G, Gupta NP. Drug therapy for idiopathic male infertility: rationale versus evidence. J Urol. 2006;176(4 Pt 1): 1307–12.

    CAS  Google Scholar 

  218. Cantineau AE, Janssen MJ, Cohlen BJ. Synchronised approach for intrauterine insemination in subfertile couples. Cochrane Database Syst Rev. 2010;(4):CD006942.

    Google Scholar 

  219. Boomsma CM, Heineman MJ, Cohlen BJ, Farquhar C. Semen preparation techniques for intrauterine insemination. Cochrane Database Syst Rev. 2007;(4):CD004507.

    Google Scholar 

  220. Guzick DS, Carson SA, Coutifaris C, Overstreet JW, Factor-Litvak P, Steinkampf MP, et al. Efficacy of superovulation and intrauterine insemination in the treatment of infertility. National Cooperative Reproductive Medicine Network. N Engl J Med. 1999;340(3):177–83.

    CAS  Google Scholar 

  221. EW Group. Intrauterine insemination. Hum Reprod Update. 2009;15(3):265–77.

    Google Scholar 

  222. Cohlen BJ. Should we continue performing intrauterine inseminations in the year 2004? Gynecol Obstet Invest. 2005;59(1):3–13.

    CAS  Google Scholar 

  223. Dickey RP, Taylor SN, Lu PY, Sartor BM, Rye PH, Pyrzak R. Relationship of follicle numbers and estradiol levels to multiple implantation in 3,608 intrauterine insemination cycles. Fertil Steril. 2001;75(1):69–78.

    CAS  Google Scholar 

  224. Khalil MR, Rasmussen PE, Erb K, Laursen SB, Rex S, Westergaard LG. Homologous intrauterine insemination. An evaluation of prognostic factors based on a review of 2473 cycles. Acta Obstet Gynecol Scand. 2001;80(1):74–81.

    CAS  Google Scholar 

  225. Bagis T, Haydardedeoglu B, Kilicdag EB, Cok T, Simsek E, Parlakgumus AH. Single versus double intrauterine insemination in multi-follicular ovarian hyperstimulation cycles: a randomized trial. Hum Reprod. 2010;25(7):1684–90.

    Google Scholar 

  226. Cantineau AE, Heineman MJ, Cohlen BJ. Single versus double intrauterine insemination in stimulated cycles for subfertile couples: a systematic review based on a Cochrane review. Hum Reprod. 2003;18(5):941–6.

    CAS  Google Scholar 

  227. Ghanem ME, Bakre NI, Emam MA, Al Boghdady LA, Helal AS, Elmetwally AG, et al. The effects of timing of intrauterine insemination in relation to ovulation and the number of inseminations on cycle pregnancy rate in common infertility etiologies. Hum Reprod. 2011;26(3):576–83.

    Google Scholar 

  228. Tonguc E, Var T, Onalan G, Altinbas S, Tokmak A, Karakas N, et al. Comparison of the effectiveness of single versus double intrauterine insemination with three different timing regimens. Fertil Steril. 2010;94(4):1267–70.

    Google Scholar 

  229. Wiser A, Shalom-Paz E, Reinblatt SL, Son WY, Das M, Tulandi T, et al. Ovarian stimulation and intrauterine insemination in women aged 40 years or more. Reprod Biomed Online. 2012;24(2): 170–3.

    Google Scholar 

  230. Dickey RP, Pyrzak R, Lu PY, Taylor SN, Rye PH. Comparison of the sperm quality necessary for successful intrauterine insemination with World Health Organization threshold values for normal sperm. Fertil Steril. 1999;71(4):684–9.

    CAS  Google Scholar 

  231. Merviel P, Heraud MH, Grenier N, Lourdel E, Sanguinet P, Copin H. Predictive factors for pregnancy after intrauterine insemination (IUI): an analysis of 1038 cycles and a review of the literature. Fertil Steril. 2010;93(1):79–88.

    Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology—Reproductive Endocrinology, University of Utah Healthcare Hospital, 50 North Medical Drive, Salt Lake City, UT, 84132, USA

    Mark Gibson MD & Ahmad O. Hammoud MD, MPH

  2. Utah Center for Reproductive Medicine, 675 Arapeen Drive, Suite 205, Salt Lake City, UT, 84108, USA

    Mark Gibson MD & Ahmad O. Hammoud MD, MPH

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  1. Cleveland Clinic, Ob/Gyn & Women's Health Institute, Euclid Ave 9500, Cleveland, 44195, Ohio, USA

    Tommaso Falcone

  2. Duke University Medical Center, Duke University School of Medicine, Department of Obstetrics and Gynecology, Erwin Rd 2301, Durham, 27705, North Carolina, USA

    William W. Hurd

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Gibson, M., Hammoud, A.O. (2013). Male Infertility. In: Falcone, T., Hurd, W. (eds) Clinical Reproductive Medicine and Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6837-0_11

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