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Role of Reactive Stroma in Prostate Cancer

  • Rebeca San Martin
  • David R. Rowley
Chapter
Part of the Protein Reviews book series (PRON, volume 16)

Abstract

Reactive stroma initiates at sites of epithelial damage to mediate tissue repair and restore homeostasis. Genomic instability of epithelial cells at sites of early lesions such as prostatic intraepithelial neoplasia produces a similar breach of the epithelial barrier and an initiation of reactive stroma. Reactive stromal cells, termed myofibroblasts and carcinoma-associated fibroblasts, have been shown to originate potentially from several sources including tissue fibroblasts, resident stromal stem cells, vascular cells, and marrow-derived mesenchymal stem cells. Several growth factors such as transforming growth factor-β and interleukin-8 induce reactive stroma and regulate several downstream factors expressed in reactive stroma. Reactive stroma in prostate cancer is heterogeneous, and the amount of reactive stroma is predictive of disease progression. The heterogeneity of cells in reactive stroma is possibly a key aspect of the tumor-promoting properties. It is likely that reactive stroma biology is an important aspect of tumor progression to metastasis and acquired therapeutic resistance. Targeting the tumor microenvironment reactive stroma together with direct targeting of cancer cells may represent an effective therapeutic approach for the treatment of prostate cancer.

Keywords

Prostate Cancer Tumor Microenvironment Connective Tissue Growth Factor Wound Repair Prostatic Intraepithelial Neoplasia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Mayo Clinic 2013

Authors and Affiliations

  1. 1.Department of Molecular and Cellular BiologyBaylor College of MedicineHoustonUSA

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