Obesity, Inflammation, Nonalcoholic Fatty Liver Disease, and Hepatocellular Carcinoma

  • Naim AlkhouriEmail author
  • Arthur McCullough
Part of the Energy Balance and Cancer book series (EBAC, volume 7)


  • Hepatocellular carcinoma (HCC) is a common malignancy worldwide that is increasing in incidence in the United States.

  • Viral and alcohol-related liver diseases account for most cases; however, a significant number of patients with HCC do not have a known underlying chronic liver disease.

  • New evidence suggests that obesity and type 2 diabetes may play a significant role in the development of HCC.

  • Nonalcoholic fatty liver disease (NAFLD) is very common in patients with obesity and diabetes and may progress to cirrhosis and HCC.

  • Insulin resistance, adipose tissue inflammation, adipokines, and inflammatory cytokines comprise mechanistic pathways that link obesity with NAFLD and HCC.


Alcoholic Liver Disease Nonalcoholic Fatty Liver Disease Primary Liver Cancer NAFLD Patient NASH Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Digestive Disease InstituteCleveland Clinic FoundationClevelandUSA

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