Inflammation, Obesity, and Colon Cancer

  • Stephanie K. Doerner
  • Jason D. HeaneyEmail author
Part of the Energy Balance and Cancer book series (EBAC, volume 7)


The general focus of this chapter is to overview the contribution of obesity-­induced intestinal inflammation to colorectal cancer (CRC) incidence. Using inflammatory bowel disease as a model, the mechanisms by which gastrointestinal microbes and obesity-associated, adipose-derived mediators of inflammatory increase CRC risk will be discussed. Particular emphasis will be placed on the direct impact of these factors on intestinal epithelial cell proliferation, survival, and neoplastic transformation. Additionally, the influence of inflammatory factors on immune cell function and the indirect effect of altered immunity on intestinal epithelial cell proliferation and survival, and CRC risk will be explored.


Ulcerative Colitis Adenomatous Polyposis Coli Dextran Sodium Sulfate Intestinal Inflammation Aberrant Crypt Focus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of GeneticsCase Western Reserve University School of MedicineClevelandUSA
  2. 2.Department of Molecular and Human GeneticsBaylor College of MedicineHoustonUSA

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