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Vascular Targeting of Adipose Tissue

  • Ahmad Salameh
  • Mikhail G. KoloninEmail author
Chapter
  • 1.5k Downloads
Part of the Energy Balance and Cancer book series (EBAC, volume 7)

Abstract

Obesity is a rapidly increasing worldwide threat to health due to its ­association with cardiovascular disease, diabetes, cancer, and a number of other medical conditions. Considerable efforts are underway to develop drugs for obesity prevention and treatment. Like tumors, white adipose tissue (WAT) overgrowing in obesity depends on functional blood vessels for its expansion and maintenance. Recent findings indicate the apparent vasculogenic role of WAT-derived cells recruited by tumors. Based on these notions, endothelial and perivascular cell populations in WAT have been considered as potential therapy targets in the context of obesity and cancer. In this chapter, we discuss studies aimed at inactivation of WAT vasculature and evaluate it as a prospective approach to treating obesity and its potential implications for cancer and other diseases.

Keywords

Vascular Endothelial Growth Factor Adipose Tissue Brown Adipose Tissue White Adipose Tissue Subcutaneous White Adipose Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.The University of Texas M.D. Anderson Cancer CenterHoustonUSA
  2. 2.The University of Texas Health Science Center at HoustonHoustonUSA

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