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Vascular Targeting of Adipose Tissue

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Book cover Obesity, Inflammation and Cancer

Part of the book series: Energy Balance and Cancer ((EBAC,volume 7))

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Abstract

Obesity is a rapidly increasing worldwide threat to health due to its ­association with cardiovascular disease, diabetes, cancer, and a number of other medical conditions. Considerable efforts are underway to develop drugs for obesity prevention and treatment. Like tumors, white adipose tissue (WAT) overgrowing in obesity depends on functional blood vessels for its expansion and maintenance. Recent findings indicate the apparent vasculogenic role of WAT-derived cells recruited by tumors. Based on these notions, endothelial and perivascular cell populations in WAT have been considered as potential therapy targets in the context of obesity and cancer. In this chapter, we discuss studies aimed at inactivation of WAT vasculature and evaluate it as a prospective approach to treating obesity and its potential implications for cancer and other diseases.

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Authors and Affiliations

  1. The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1347, Room T7.3821, 301439, Houston, TX, 77030-1439, USA

    Ahmad Salameh Ph.D.

  2. The University of Texas Health Science Center at Houston, 1825 Pressler Street, Room 630-G, Houston, TX, 77030, USA

    Mikhail G. Kolonin Ph.D.

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  1. Ahmad Salameh Ph.D.
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  2. Mikhail G. Kolonin Ph.D.
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Correspondence to Mikhail G. Kolonin Ph.D. .

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  1. , Department of Medicine, Weill Cornell Medical College, 525 E. 68th St. Room F-206, New York, 10065, New York, USA

    Andrew J. Dannenberg

  2. School of Medicine, Center for Science, Health & Society, Case Western Reserve University, Euclid Ave. 10900, Cleveland, 44106, Ohio, USA

    Nathan A. Berger

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Salameh, A., Kolonin, M.G. (2013). Vascular Targeting of Adipose Tissue. In: Dannenberg, A., Berger, N. (eds) Obesity, Inflammation and Cancer. Energy Balance and Cancer, vol 7. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6819-6_15

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