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Calorie Restriction and Cancer Prevention: Established and Emerging Mechanisms

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Obesity, Inflammation and Cancer

Part of the book series: Energy Balance and Cancer ((EBAC,volume 7))

Abstract

Calorie restriction (CR) is one of the most potent, broadly acting dietary interventions for inducing weight loss and for inhibiting cancer in experimental models. Translation of the mechanistic lessons learned from research on CR to cancer prevention strategies in humans is important given the high prevalence of excess energy intake, obesity, and metabolic syndrome in many parts of the world and also given the established links between obesity-associated metabolic perturbations and increased risk and/or progression of many types of cancers. This chapter synthesizes findings on the biological mechanisms underlying many of the anticancer effects of CR, with emphasis on the role of inflammatory processes and growth factor signaling (well-established mechanisms) as well as vascular perturbations, autophagy, and sirtuins (emerging mechanisms). These CR-responsive pathways and processes represent targets for translating CR research into effective cancer prevention strategies in humans.

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Authors and Affiliations

  1. Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX, USA

    Stephen D. Hursting Ph.D., Nikki A. Ford Ph.D., Sarah M. Dunlap Ph.D. & Laura M. Lashinger Ph.D.

  2. Department of Molecular Carcinogenesis, The University of Texas-MD Anderson Cancer Center, Smithville, TX, USA

    Stephen D. Hursting Ph.D.

  3. Clinical Science Consulting, Austin, TX, USA

    Marcie J. Hursting Ph.D.

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  1. Stephen D. Hursting Ph.D.
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  2. Nikki A. Ford Ph.D.
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  3. Sarah M. Dunlap Ph.D.
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  4. Marcie J. Hursting Ph.D.
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  5. Laura M. Lashinger Ph.D.
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Correspondence to Stephen D. Hursting Ph.D. .

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  1. , Department of Medicine, Weill Cornell Medical College, 525 E. 68th St. Room F-206, New York, 10065, New York, USA

    Andrew J. Dannenberg

  2. School of Medicine, Center for Science, Health & Society, Case Western Reserve University, Euclid Ave. 10900, Cleveland, 44106, Ohio, USA

    Nathan A. Berger

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Hursting, S.D., Ford, N.A., Dunlap, S.M., Hursting, M.J., Lashinger, L.M. (2013). Calorie Restriction and Cancer Prevention: Established and Emerging Mechanisms. In: Dannenberg, A., Berger, N. (eds) Obesity, Inflammation and Cancer. Energy Balance and Cancer, vol 7. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6819-6_14

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