Obesity, Inflammation, and Prostate Cancer

  • Jorge Blando
  • Achinto Saha
  • Kaoru Kiguchi
  • John DiGiovanni
Chapter
Part of the Energy Balance and Cancer book series (EBAC, volume 7)

Abstract

Obesity and the associated metabolic syndrome produce a complex set of alterations both systemically and locally in tissues that support cancer development and progression. In prostate cancer (PCa), the weight of evidence suggests that obesity is primarily associated with more aggressive disease and increased risk of biochemical failure following prostatectomy or radiation treatment. Inflammation processes and inflammation-associated signaling pathways are upregulated in the obese state, and both human and mouse studies support an important role for inflammation in obesity-driven PCa progression. Inflammation signaling pathways along with other signaling pathways (e.g., growth factor signaling pathways) altered in the obese state represent promising targets for both lifestyle and pharmacologic interventions to prevent or control PCa progression.

Keywords

Obesity Estrogen Testosterone Androgen Metformin 

Notes

Acknowledgments

Achinto Saha is supported by a Cancer Prevention Research Institute of Texas postdoctoral fellowship award RP101501 from the State of Texas.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jorge Blando
    • 1
  • Achinto Saha
    • 1
  • Kaoru Kiguchi
    • 1
  • John DiGiovanni
    • 1
    • 2
    • 3
  1. 1.Division of Pharmacology and Toxicology, College of PharmacyThe University of Texas at AustinAustinUSA
  2. 2.Department of Nutritional Sciences, College of Natural SciencesThe University of Texas at AustinAustinUSA
  3. 3.Dell Pediatric Research InstituteThe University of Texas at AustinAustinUSA

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