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Obesity, Inflammation, and Insulin Resistance

  • Lesley G. Ellies
  • Andrew Johnson
  • Jerrold M. OlefskyEmail author
Chapter
Part of the Energy Balance and Cancer book series (EBAC, volume 7)

Abstract

Obesity is a pressing public health concern as it leads to a collection of abnormalities often termed the metabolic syndrome. Molecular studies are revealing novel pathways by which obesity-associated hormonal, nutrient, and tissue ­factors can stimulate the chronic low-grade inflammation that leads to insulin resistance. Signaling interactions between proinflammatory immune cells, particularly macrophages and lymphocytes, and insulin target cells in the liver and adipose tissue are key to this process and provide potential opportunities for the development of targeted therapies to improve insulin sensitivity and correct energy imbalance.

Keywords

Insulin Resistance Treg Cell Unfold Protein Response Visceral Adipose Tissue Neutrophil Elastase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

ATM

Adipose tissue macrophage

DIO

Diet-induced obesity

FFA

Free fatty acid

GPCR

G protein-coupled receptor

HFD

High-fat diet

IL

Interleukin

SAT

Subcutaneous adipose tissue

SFA

Saturated fatty acid

TNF

Tumor necrosis factor

VAT

Visceral adipose tissue

WAT

White adipose tissue

Notes

Acknowledgment

This work was supported by NIH grant U54CA155435 and DOD grant BC102147.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Lesley G. Ellies
    • 1
  • Andrew Johnson
    • 2
  • Jerrold M. Olefsky
    • 2
    Email author
  1. 1.Department of PathologyUniversity of California, San DiegoLa JollaUSA
  2. 2.Department of Medicine, Division of Endocrinology and MetabolismUniversity of California, San DiegoLa JollaUSA

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