Abstract
The practice of transferring multiple embryos in an in vitro fertilization (IVF) cycle has led to an iatrogenic epidemic of multiple pregnancies. IVF multiple pregnancies cause significant morbidity and mortality for both mothers and infants, and place a substantial financial burden on the couple and the society. While increasing awareness of these problems has led to a decrease in the average number of embryos transferred, multiple embryo transfer remains the norm in most countries and results in multiple pregnancy rates of 20–30 % worldwide. Recently, several countries have placed legal restrictions on the number of embryos transferred in return of government reimbursement for IVF. Such policy seems to dramatically decrease multiple pregnancies while maintaining pregnancy rates and increasing access to treatment. Better selection of gametes and implantation competent embryos will undoubtedly increase the adoption of elective single embryo transfers and further contribute to a decrease in IVF multiple pregnancies.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Steptoe PC, Edwards RG. Birth after the reimplantation of a human embryo. Lancet. 1978;2(8085):366.
Trounson AO, Leeton JF, Wood C, et al. Pregnancies in humans by fertilization in vitro and embryo transfer in the controlled ovulatory cycle. Science. 1981; 212(4495):681–2.
Lopata A. Successes and failures in human in vitro fertilization. Nature. 1980;288(5792):642–3.
Hughes EG, Fedorkow DM, Daya S, et al. The routine use of gonadotropin-releasing hormone agonists prior to in vitro fertilization and gamete intrafallopian transfer: a meta-analysis of randomized controlled trials. Fertil Steril. 1992;58(5):888–96.
Engmann L, Maconochie N, Bekir JS, et al. Cumulative probability of clinical pregnancy and live birth after a multiple cycle IVF package: a more realistic assessment of overall and age-specific success rates? Br J Obstet Gynaecol. 1999;106(2):165–70.
Belgian College of Physicians for Reproductive Medicine. Annual report for activities of medically assisted reproduction, Belgium, version 1.0.2008. 2008. Available from: http://www.belrap.be/Documents/Reports/Global/Report_IVF08_16SEP10.pdf
Centers for Disease Control and Prevention, American Society for Reproductive Medicine, Society for Assisted Reproductive Technology. 2006 Assisted reproductive technology success rates: national summary and fertility clinic reports. Atlanta: US Department of Health and Human Services, Centers for Disease Control and Prevention; 2008.
Gunby J, Bissonnette F, Librach C, Cowan L. Assisted reproductive technologies (ART) in Canada: 2007 results from the Canadian ART Register. Fertil Steril. 2011;95(2):542–7.e1–10.
Adamson D, Baker V. Multiple births from assisted reproductive technologies: a challenge that must be met. Fertil Steril. 2004;81(3):517–22, discussion 526.
Sunderam S, Chang J, Flowers L, et al. Assisted reproductive technology surveillance—United States, 2006. Morb Mortal Wkly Rep. 2009;58(SS–5):1–26.
Reddy UM, Wapner RJ, Rebar RW, Tasca RJ. Infertility, assisted reproductive technology, and adverse pregnancy outcomes: executive summary of a National Institute of Child Health and Human Development workshop. Obstet Gynecol. 2007;109(4):967–77.
Oleszczuk JJ, Oleszczuk AK, Keith DM, Keith LG. Twin and triplet births: facts, figures, and costs. Female Patient. 2003;28(6):11.
Martin JA, Hamilton BE, Sutton PD, et al. Births: final data for 2005. Natl Vital Stat Rep. 2007;56(6):1–103.
Luke B, Martin JA. The rise in multiple births in the United States: who, what, when, where, and why. Clin Obstet Gynecol. 2004;47(1):118–33.
Hvidtjorn D, Grove J, Schendel DE, et al. Cerebral palsy among children born after in vitro fertilization: the role of preterm delivery–a population-based, cohort study. Pediatrics. 2006;118(2):475–82.
Petterson B, Nelson KB, Watson L, Stanley F. Twins, triplets, and cerebral palsy in births in Western Australia in the 1980s. BMJ. 1993;307(6914):1239–43.
Yokoyama Y, Shimizu T, Hayakawa K. Prevalence of cerebral palsy in twins, triplets and quadruplets. Int J Epidemiol. 1995;24(5):943–8.
Malone FD, Kaufman GE, Chelmow D, et al. Maternal morbidity associated with triplet pregnancy. Am J Perinatol. 1998;15(1):73–7.
The ESHRE Capri Workshop Group. Multiple gestation pregnancy. Hum Reprod. 2000;15(8):1856–64.
Chelmow D, Penzias AS, Kaufman G, Cetrulo C. Costs of triplet pregnancy. Am J Obstet Gynecol. 1995;172(2 Pt 1):677–82.
Luke B, Bigger HR, Leurgans S, Sietsema D. The cost of prematurity: a case-control study of twins vs singletons. Am J Public Health. 1996;86(6):809–14.
Behrman R, Butler A, editors. Board on Health Sciences Policy, Institute of Medicine. Preterm birth: causes, consequences, and prevention. Washington, DC: The National Academies; 2006.
Bromer JG, Ata B, Seli M, et al. Preterm deliveries that result from multiple pregnancies associated with assisted reproductive technologies in the USA: a cost analysis. Curr Opin Obstet Gynecol. 2011;23(3):168–73.
Centers for Disease Control and Prevention, American Society for Reproductive Medicine, Society for Assisted Reproductive Technology. 2009 Assisted reproductive technology success rates: national summary and fertility clinic reports. Atlanta: US Department of Health and Human Services, Centers for Disease Control and Prevention; 2011.
de Mouzon J, Goossens V, Bhattacharya S, et al. Assisted reproductive technology in Europe, 2006: results generated from European registers by ESHRE. Hum Reprod. 2010;25(8):1851–62.
Nygren KG, Sullivan E, Zegers-Hochschild F, et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART) world report: assisted reproductive technology 2003. Fertil Steril. 2011;95(7):2209–22; 2222.e1–17.
Gordts S, Campo R, Puttemans P, et al. Belgian legislation and the effect of elective single embryo transfer on IVF outcome. Reprod Biomed Online. 2005;10(4):436–41.
Van Landuyt L, Verheyen G, Tournaye H, et al. New Belgian embryo transfer policy leads to sharp decrease in multiple pregnancy rate. Reprod Biomed Online. 2006;13(6):765–71.
Karlstrom PO, Bergh C. Reducing the number of embryos transferred in Sweden-impact on delivery and multiple birth rates. Hum Reprod. 2007;22(8):2202–7.
Bissonnette F, Phillips SJ, Gunby J, et al. Working to eliminate multiple pregnancies: a success story in Quebec. Reprod Biomed Online. 2011;23(4):500–4.
Ata B, Seli E. Economics of assisted reproductive technologies. Curr Opin Obstet Gynecol. 2010;22(3):183–8.
Martin JR, Bromer JG, Sakkas D, Patrizio P. Insurance coverage and in vitro fertilization outcomes: a U.S. perspective. Fertil Steril. 2011;95(3):964–9.
Red Latinoamericana de Reproduccion Asistida. Registro Latinoamericano de Reproducción Asistida, 2009. 2012. Available from: http://www.redlara.com/aa_ingles/quem_somos.asp
Japan Society of Obstetrics and Gynecology. ART registry of Japan, 2008. 2009. Available from: http://www.jsog.or.jp/english/
Fertility Society of Australia, Reproductive Technology Accreditaion Committee. Code of practice for assisted reproductive technology units. Melbourne: FSA; 2010.
Wang YA, Macaldowie A, Hayward I, et al. Assisted reproductive technology in Australia and New Zealand 2009. Australian Institute of Health and Welfare, Assisted Reproduction Series. 2011; No. 15.
Acknowledgments
The authors would like to acknowledge Basak Balaban from the American Hospital, Istanbul, Turkey, Weon Young Son from McGill University Health Centre, Montreal, Quebec, David Mortimer from Oozoa, Vancouver, Canada, David Edgar from Melbourne IVF, Australia, Osamu Okitsu from Miyake Clinic, Japan, Soledad Sepulveda, Grup PRANOR, Peru. We are thankful for their kind help in providing essential information for this chapter.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media New York
About this chapter
Cite this chapter
Ata, B., Seli, E. (2013). Current Practices and Regulations for Embryo Transfer Worldwide: Implications on IVF Outcome. In: Gardner, D., Sakkas, D., Seli, E., Wells, D. (eds) Human Gametes and Preimplantation Embryos. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6651-2_1
Download citation
DOI: https://doi.org/10.1007/978-1-4614-6651-2_1
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-6650-5
Online ISBN: 978-1-4614-6651-2
eBook Packages: MedicineMedicine (R0)