Case Study B: Radiation Monotherapy for Extensive Local and In-Transit Merkel Cell Carcinoma



Presentation: A 93-year-old male presented to the dermatologist with multiple firm, deeply erythematous nodules covering the majority of the parietal scalp (Fig. 13.1). He stated that the nodules appeared rapidly, never bled, and were not painful. Punch biopsies were performed at two locations and both were shown to be consistent with Merkel cell carcinoma (MCC). His past medical history was notable for hypertension, hyperlipidemia, and coronary artery disease.


Renal Cell Carcinoma Sentinel Lymph Node Biopsy Merkel Cell Carcinoma Fine Needle Aspirate Multidisciplinary Tumor Board 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Lemos BD et al. Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system. J Am Acad Dermatol. 2010;63(5):751–61.PubMedCrossRefGoogle Scholar
  2. 2.
    Pape E et al. Radiotherapy alone for Merkel cell carcinoma: a comparative and retrospective study of 25 patients. J Am Acad Dermatol. 2011;65(5):983–90.PubMedCrossRefGoogle Scholar
  3. 3.
    Colgan MB et al. The predictive value of imaging studies in evaluating regional lymph node involvement in Merkel cell carcinoma. J Am Acad Dermatol. 2012; 67(6):1250–6.PubMedCrossRefGoogle Scholar
  4. 4.
    Bichakjian CK et al. Merkel cell carcinoma: critical review with guidelines for multidisciplinary management. Cancer. 2007;110(1):1–12.PubMedCrossRefGoogle Scholar
  5. 5.
    Allen PJ et al. Merkel cell carcinoma: prognosis and treatment of patients from a single institution. J Clin Oncol. 2005;23(10):2300–9.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Sherrif F. Ibrahim
    • 1
  • Sue S. Yom
    • 2
  • Siegrid S. Yu
    • 3
  1. 1.Department of DermatologyUniversity of Rochester Medical CenterRochesterUSA
  2. 2.Department of Radiation OncologyUniversity of California, San FranciscoSan FranciscoUSA
  3. 3.Department of Clinical DermatologyUCSF Dermatologic Surgery & Laser CenterSan FranciscoUSA

Personalised recommendations