Emergency Contraception

Chapter

Abstract

Emergency contraception (EC) is a method of birth control that is taken after unprotected intercourse. It can be taken when a regular method of contraception is not used or is used incorrectly. EC is particularly important for victims of sexual assault or reproductive coercion. There are three methods of EC available in the USA: oral levonorgestrel, oral ulipristal acetate, and the copper intrauterine device (Cu-IUD). The Cu-IUD is most effective and offers both emergency and ongoing contraception. There are no contraindications to adolescents using EC, and side effects are generally mild. One form of levonorgestrel EC, Plan B One-Step, is now available over-the-counter for women of all ages. Other forms of levonorgestrel EC require a prescription for women younger than 17. Routinely discussing EC, providing timely access to copper IUDs for teens facing contraceptive emergencies, and offering advance prescription for EC are all ways to increase teens’ access to EC. Increased information about and access to EC does not increase teens’ sexual risk-taking behavior.

Keywords

Fatigue Obesity Prostaglandin Progesterone Estradiol 

References

  1. 1.
    Morris JM, Van Wagenen G. Compounds interfering with ovum implantation and development 3. The role of estrogens. Am J Obstet Gynecol. 1966;96(6):804–15.PubMedGoogle Scholar
  2. 2.
    Yuzpe AA, Thurlow HJ, Ramzy I, Leyshon JI. Post coital contraception—a pilot study. J Reprod Med. 1974;13(2):53–8.PubMedGoogle Scholar
  3. 3.
    Kesseru E, Garmendia F, Westphal N, Parada J. The hormonal and peripheral effects of d-norgestrel in postcoital contraception. Contraception. 1974;10(4):411–24.PubMedCrossRefGoogle Scholar
  4. 4.
    First emergency contraceptive product hits U.S. market shelves. Contracept Technol Update. 1998;19(11):141–3.Google Scholar
  5. 5.
    Lippes J, Malik T, Tatum HJ. The postcoital copper-T. Adv Plan Parent. 1976;11(1):24–9.PubMedGoogle Scholar
  6. 6.
    Long-term reversible contraception. Twelve years of experience with the TCu380A and TCu220C. Contraception. 1997;56(6):341–52.Google Scholar
  7. 7.
    Randomised controlled trial of levonorgestrel versus the Yuzpe regimen of combined oral contraceptives for emergency contraception. Task Force on Postovulatory Methods of Fertility Regulation. Lancet. 1998;352(9126):428–33.Google Scholar
  8. 8.
    von Hertzen H, Piaggio G, Ding J, Chen J, Song S, Bartfai G, et al. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception: a WHO multicentre randomised trial. Lancet. 2002;360(9348):1803–10.CrossRefGoogle Scholar
  9. 9.
    Glasier A, Cameron ST, Blithe D, Scherrer B, Mathe H, Levy D, et al. Can we identify women at risk of pregnancy despite using emergency contraception? Data from randomized trials of ulipristal acetate and levonorgestrel. Contraception. 2011;84(4):363–7.PubMedCrossRefGoogle Scholar
  10. 10.
    Glasier A, Thong KJ, Dewar M, Mackie M, Baird DT. Postcoital contraception with mifepristone. Lancet. 1991;337(8754):1414–5.PubMedCrossRefGoogle Scholar
  11. 11.
    Webb AM. Alternative treatments in oral postcoital contraception: interim results. Adv Contracept. 1991;7(2–3):271–9.PubMedCrossRefGoogle Scholar
  12. 12.
    Cheng L, Gulmezoglu AM, Piaggio G, Ezcurra E, Van Look PF. Interventions for emergency contraception. Cochrane Database Syst Rev. 2008;(2):CD001324.Google Scholar
  13. 13.
    Martinez G, Copen CE, Abma JC. Teenagers in the United States: sexual activity, contraceptive use, and childbearing, 2006–2010 national survey of family growth. Vital Health Stat 23. 2011;31:1–35.PubMedGoogle Scholar
  14. 14.
    Mosher WD, Jones J. Use of contraception in the United States: 1982–2008. Vital Health Stat 23. 2010;29:1–44.PubMedGoogle Scholar
  15. 15.
    Sagiroglu N. Phagocytosis of spermatozoa in the uterine cavity of woman using intrauterine device. Int J Fertil. 1971;16(1):1–14.PubMedGoogle Scholar
  16. 16.
    Ammala M, Nyman T, Strengell L, Rutanen EM. Effect of intrauterine contraceptive devices on cytokine messenger ribonucleic acid expression in the human endometrium. Fertil Steril. 1995;63(4):773–8.PubMedGoogle Scholar
  17. 17.
    El-Habashi M, El-Sahwi S, Gawish S, Osman M. Effect of Lippes loop on sperm recovery from human fallopian tubes. Contraception. 1980;22(5):549–55.PubMedCrossRefGoogle Scholar
  18. 18.
    Ortiz ME, Croxatto HB, Bardin CW. Mechanisms of action of intrauterine devices. Obstet Gynecol Surv. 1996;51(12 Suppl):S42–51.PubMedCrossRefGoogle Scholar
  19. 19.
    Hapangama D, Glasier AF, Baird DT. The effects of peri-ovulatory administration of levonorgestrel on the menstrual cycle. Contraception. 2001;63(3):123–9.PubMedCrossRefGoogle Scholar
  20. 20.
    Marions L, Cekan SZ, Bygdeman M, Gemzell-Danielsson K. Effect of emergency contraception with levonorgestrel or mifepristone on ovarian function. Contraception. 2004;69(5):373–7.PubMedCrossRefGoogle Scholar
  21. 21.
    Durand M, del Carmen Cravioto M, Raymond EG, et al. The mechanism of action of short-term levonorgestrel administration in emergency contraception. Contraception. 2001;64:227–34.PubMedCrossRefGoogle Scholar
  22. 22.
    Brache V, Cochon L, Jesam C, Maldonado R, Salvatierra AM, Levy DP, et al. Immediate pre-ovulatory administration of 30 mg ulipristal acetate significantly delays follicular rupture. Hum Reprod. 2010;25(9):2256–63.PubMedCrossRefGoogle Scholar
  23. 23.
    Stratton P, Levens ED, Hartog B, Piquion J, Wei Q, Merino M, et al. Endometrial effects of a single early luteal dose of the selective progesterone receptor modulator CDB-2914. Fertil Steril. 2010;93(6):2035–41.PubMedCentralPubMedCrossRefGoogle Scholar
  24. 24.
    Trussell J, Ellertson C, von Hertzen H, Bigrigg A, Webb A, Evans M, et al. Estimating the effectiveness of emergency contraceptive pills. Contraception. 2003;67(4):259–65.PubMedCrossRefGoogle Scholar
  25. 25.
    Stirling A, Glasier A. Estimating the efficacy of emergency contraception—how reliable are the data? Contraception. 2002;66(1):19–22.PubMedCrossRefGoogle Scholar
  26. 26.
    Raymond E, Taylor D, Trussell J, Steiner MJ. Minimum effectiveness of the levonorgestrel regimen of emergency contraception. Contraception. 2004;69(1):79–81.PubMedCrossRefGoogle Scholar
  27. 27.
    Fine P, Mathe H, Ginde S, Cullins V, Morfesis J, Gainer E. Ulipristal acetate taken 48–120 hours after intercourse for emergency contraception. Obstet Gynecol. 2010;115(2 Pt 1):257–63.PubMedCrossRefGoogle Scholar
  28. 28.
    Creinin MD, Schlaff W, Archer DF, Wan L, Frezieres R, Thomas M, et al. Progesterone receptor modulator for emergency contraception: a randomized controlled trial. Obstet Gynecol. 2006;108(5):1089–97.PubMedCentralPubMedCrossRefGoogle Scholar
  29. 29.
    Glasier AF, Cameron ST, Fine PM, Logan SJ, Casale W, Van Horn J, et al. Ulipristal acetate versus levonorgestrel for emergency contraception: a randomised non-inferiority trial and meta-analysis. Lancet. 2010;375(9714):555–62.PubMedCrossRefGoogle Scholar
  30. 30.
    Raine TR, Ricciotti N, Sokoloff A, Brown BA, Hummel A, Harper CC. An over-the-counter simulation study of a single-tablet emergency contraceptive in young females. Obstet Gynecol. 2012;119(4):772–9.PubMedCrossRefGoogle Scholar
  31. 31.
    Teal SB, Sheeder J. IUD use in adolescent mothers: retention, failure and reasons for discontinuation. Contraception. 2012;85(3):270–4.PubMedCrossRefGoogle Scholar
  32. 32.
    Ho PC, Kwan MS. A prospective randomized comparison of levonorgestrel with the Yuzpe regimen in post-coital contraception. Hum Reprod. 1993;8(3):389–92.PubMedGoogle Scholar
  33. 33.
    Committee ACOG. Opinion no. 450: Increasing use of contraceptive implants and intrauterine devices to reduce unintended pregnancy. Obstet Gynecol. 2009;114(6):1434–8.CrossRefGoogle Scholar
  34. 34.
    Committee on Adolescent Health Care Long-Acting Reversible Contraception Working Group, The American College of Obstetricians and Gynecologists. Committee opinion no. 539: adolescents and long-acting reversible contraception: implants and intrauterine devices. Obstet Gynecol. 2012;120:983–8.CrossRefGoogle Scholar
  35. 35.
    American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 121: long-acting reversible contraception: implants and intrauterine devices. Obstet Gynecol. 2011;118(1):184–96.CrossRefGoogle Scholar
  36. 36.
    Brahmi D, Steenland MW, Renner RM, Gaffield ME, Curtis KM. Pregnancy outcomes with an IUD in situ: a systematic review. Contraception. 2012;85(2):131–9.PubMedCrossRefGoogle Scholar
  37. 37.
    Zhang L, Chen J, Wang Y, Ren F, Yu W, Cheng L. Pregnancy outcome after levonorgestrel-only emergency contraception failure: a prospective cohort study. Hum Reprod. 2009;24(7):1605–11.PubMedCrossRefGoogle Scholar
  38. 38.
    Ghosh B, Dadhwal V, Deka D, Ramesan CK, Mittal S. Ectopic pregnancy following levonorgestrel emergency contraception: a case report. Contraception. 2009;79(2):155–7.PubMedCrossRefGoogle Scholar
  39. 39.
    Cabar FR, Pereira PP, Zugaib M. Ectopic pregnancy following levonorgestrel emergency contraception. Contraception. 2009;80(2):227; author reply 227–8.PubMedCrossRefGoogle Scholar
  40. 40.
    Kozinszky Z, Bakken RT, Lieng M. Ectopic pregnancy after levonorgestrel emergency contraception. Contraception. 2011;83(3):281–3.PubMedCrossRefGoogle Scholar
  41. 41.
    Cleland K, Raymond E, Trussell J, Cheng L, Zhu H. Ectopic pregnancy and emergency contraceptive pills: a systematic review. Obstet Gynecol. 2010;115(6):1263–6.PubMedCentralPubMedCrossRefGoogle Scholar
  42. 42.
    Workowski KA, Berman S. Sexually transmitted diseases treatment guidelines 2010. MMWR Recomm Rep. 2010;59(RR-12):1–110.PubMedGoogle Scholar
  43. 43.
    U.S. Preventive Services Task Force. Screening for chlamydial infection: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2007;147(2):128–34.CrossRefGoogle Scholar
  44. 44.
    Centers for Disease Control and Prevention. U.S. selected practice recommendations for contraceptive use, 2013. MMWR Recomm Rep. 2013;62(5):1–64.Google Scholar
  45. 45.
    ella [package insert]. Morristown, NJ: Watson Pharmaceuticals; 2010. http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022474s000lbl.pdf. Accessed 1 Apr 2012.
  46. 46.
    Miller E, Decker MR, Raj A, Reed E, Marable D, Silverman JG. Intimate partner violence and health care-seeking patterns among female users of urban adolescent clinics. Matern Child Health J. 2010;14(6):910–7.PubMedCentralPubMedCrossRefGoogle Scholar
  47. 47.
    Wilkinson TA, Fahey N, Suther E, Cabral HJ, Silverstein M. Access to emergency contraception for adolescents. JAMA. 2012;307(4):362–3.PubMedCrossRefGoogle Scholar
  48. 48.
    American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 112: emergency contraception. Obstet Gynecol. 2010;115(5):1100–9.CrossRefGoogle Scholar
  49. 49.
    American Academy of Pediatrics Committee on Adolescence. Emergency contraception. Pediatrics. 2005;116(4):1026–35.CrossRefGoogle Scholar
  50. 50.
    Gold MA, Sucato GS, Conard LA, Hillard PJ. Provision of emergency contraception to adolescents. J Adolesc Health. 2004;35(1):67–70.PubMedGoogle Scholar
  51. 51.
    Raine TR, Harper CC, Rocca CH, Fischer R, Padian N, Klausner JD, et al. Direct access to emergency contraception through pharmacies and effect on unintended pregnancy and STIs: a randomized controlled trial. JAMA. 2005;293(1):54–62.PubMedCrossRefGoogle Scholar
  52. 52.
    Gold MA, Wolford JE, Smith KA, Parker AM. The effects of advance provision of emergency contraception on adolescent women’s sexual and contraceptive behaviors. J Pediatr Adolesc Gynecol. 2004;17(2):87–96.PubMedCrossRefGoogle Scholar
  53. 53.
    Belzer M, Sanchez K, Olson J, Jacobs AM, Tucker D. Advance supply of emergency contraception: a randomized trial in adolescent mothers. J Pediatr Adolesc Gynecol. 2005;18(5):347–54.PubMedCrossRefGoogle Scholar
  54. 54.
    Raymond EG, Stewart F, Weaver M, Monteith C, Van Der Pol B. Impact of increased access to emergency contraceptive pills: a randomized controlled trial. Obstet Gynecol. 2006;108(5):1098–106.PubMedCrossRefGoogle Scholar
  55. 55.
    Harper CC, Cheong M, Rocca CH, Darney PD, Raine TR. The effect of increased access to emergency contraception among young adolescents. Obstet Gynecol. 2005;106(3):483–91.PubMedCrossRefGoogle Scholar
  56. 56.
    Rocca CH, Schwarz EB, Stewart FH, Darney PD, Raine TR, Harper CC. Beyond access: acceptability, use and nonuse of emergency contraception among young women. Am J Obstet Gynecol. 2007;196(1):29.e1–6; discussion 90.e1–5.Google Scholar
  57. 57.
    Johnson R, Nshom M, Nye AM, Cohall AT. There’s always Plan B: adolescent knowledge, attitudes and intention to use emergency contraception. Contraception. 2010;81(2):128–32.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyUniversity of South FloridaTampaUSA
  2. 2.Women’s Health Services Research Unit, Center for Research on Health CareUniversity of PittsburghPittsburghUSA

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