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Toxic Neuromuscular Transmission Disorders

Chapter

Abstract

The neurotoxins affecting neuromuscular transmission may be broadly classified into three major categories: pharmacological, biological, and environmental. This chapter focuses on the direct effects of neurotoxins affecting neuromuscular transmission of man but is not meant to be a treatise on the broad topic of neuromuscular neurotoxicology. It is not possible to elaborate on all of the pharmacological and physiological effects of particular toxins beyond the scope of the NMJ nor will it discuss in detail the neuromuscular blocking effects of these neurotoxins in animals or experimental preparations.

Keywords

neurotoxicology toxicology myasthenia gravis botulism organophosphates biological toxins neuromuscular transmission Lambert-Eaton syndrome adverse events drug-induced 

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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Laboratory for Myasthenia Gravis Research, Department of Neurology, School of MedicineThe University of North Carolina at Chapel HillChapel HillUSA

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