Epigenetic Alterations in Pancreatic Cancer
Pancreatic cancer remains one of the deadliest malignancies. In addition to genetic alterations a wide variety of epigenetic aberrations have been identified in pancreatic neoplasms some of which are thought to play an important role in neoplastic development and maintenance. Newer technologies are helping to better characterize cancer epigenomes. Efforts are underway to identify epigenetic alterations that would make optimal diagnostic markers and therapeutic targets. In this chapter, we discuss recent findings in the field of pancreatic cancer epigenetics and the implications they hold for future research.
KeywordsPancreatic Cancer Histone Modification Pancreatic Cancer Cell HDAC Inhibitor Pancreatic Cancer Cell Line
This work was supported by NIH grants (CA62924, R01CA120432, and RC2CA148376), and the Michael Rolfe Foundation.
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