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Epigenetic Alterations in Pancreatic Cancer

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Molecular Genetics of Pancreatic Cancer

Abstract

Pancreatic cancer remains one of the deadliest malignancies. In addition to genetic alterations a wide variety of epigenetic aberrations have been identified in pancreatic neoplasms some of which are thought to play an important role in neoplastic development and maintenance. Newer technologies are helping to better characterize cancer epigenomes. Efforts are underway to identify epigenetic alterations that would make optimal diagnostic markers and therapeutic targets. In this chapter, we discuss recent findings in the field of pancreatic cancer epigenetics and the implications they hold for future research.

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Acknowledgements

This work was supported by NIH grants (CA62924, R01CA120432, and RC2CA148376), and the Michael Rolfe Foundation.

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Authors and Affiliations

  1. Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, MD, 21231, USA

    Michael Ayars & Michael Goggins M.D.

  2. Departments of Pathology, Medicine, and Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, MD, 21231, USA

    Michael Goggins M.D.

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  1. Michael Ayars
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  2. Michael Goggins M.D.
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Correspondence to Michael Goggins M.D. .

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  1. MED CTR ROOM 2922D, TC, University of Michigan, E Medical CTR Drive 1500, Ann Arbor, 48109-0999, Michigan, USA

    Diane M. Simeone

  2. CRB 2/STE 345, Johns Hopkins University, Orleans Street 1550, Baltimore, 21231, Maryland, USA

    Anirban Maitra

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Ayars, M., Goggins, M. (2013). Epigenetic Alterations in Pancreatic Cancer. In: Simeone, D., Maitra, A. (eds) Molecular Genetics of Pancreatic Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6549-2_9

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