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The Biology of K-Ras Signaling Pathways in Pancreatic Cancer

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Molecular Genetics of Pancreatic Cancer

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Abstract

Activating mutations in the K-Ras oncogene occur in approximately 90 % of cases of pancreatic ductal adenocarcinoma, and tumors containing mutant K-Ras often acquire a dependency on the expression of the oncogene. Therapies that block the oncogenic functions of K-Ras could have clinical efficacy for a disease that is currently refractory to all forms of treatment. This chapter describes the evidence, from both in vitro studies and studies using genetic mouse models, of the importance of oncogenic K-Ras and its downstream signaling pathways in driving pancreatic tumor formation and cancer cell growth.

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Authors and Affiliations

  1. Department of Medicine, NYU School of Medicine, 550 First Avenue, New York, NY, USA

    Helen Court & Mark R. Philips

  2. Department of Cell Biology, NYU School of Medicine, 550 First Avenue, New York, NY, USA

    Helen Court & Mark R. Philips

  3. Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, 550 First Avenue, New York, NY, USA

    Helen Court, Mark R. Philips & Dafna Bar-Sagi

  4. The Cancer Institute, NYU School of Medicine, 550 First Avenue, New York, NY, USA

    Helen Court & Mark R. Philips

Authors
  1. Helen Court
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  2. Mark R. Philips
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  3. Dafna Bar-Sagi
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Correspondence to Dafna Bar-Sagi .

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Editors and Affiliations

  1. MED CTR ROOM 2922D, TC, University of Michigan, E Medical CTR Drive 1500, Ann Arbor, 48109-0999, Michigan, USA

    Diane M. Simeone

  2. CRB 2/STE 345, Johns Hopkins University, Orleans Street 1550, Baltimore, 21231, Maryland, USA

    Anirban Maitra

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Court, H., Philips, M.R., Bar-Sagi, D. (2013). The Biology of K-Ras Signaling Pathways in Pancreatic Cancer. In: Simeone, D., Maitra, A. (eds) Molecular Genetics of Pancreatic Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6549-2_5

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