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Vesicle Trafficking in Cancer pp 177–190Cite as

Efficient Enhancement of Signalling Capacity: The Ubiquitin System

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Abstract

Ubiquitin (Ub) has emerged as a potent cellular signal that regulates a wide variety of processes in normal as well as malignant cells. Its potency is based on an elaborate system of “writing” and “reading” a diverse Ub code on substrate proteins. In this chapter we give an overview on the principles of Ub-based signalling and explain how efficiency and specificity is ensured in the cell. Moreover, we discuss how the capacity of Ub signalling is further enhanced by crosstalk with other post-translational modifications such as phosphorylation and acetylation.

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Acknowledgement

We would like to thank Tobias Kensche for his help with references and comments on the manuscript.

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Authors and Affiliations

  1. Buchmann Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University School of Medicine, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany

    Daniela Hoeller & Ivan Dikic

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  1. Daniela Hoeller
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  2. Ivan Dikic
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Correspondence to Daniela Hoeller or Ivan Dikic .

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Editors and Affiliations

  1. Department of Biological Regulation, Candiotty Bldg, Hertzel St 1, Rehovot, 76100, Israel

    Yosef Yarden

  2. , Department of Biological Regulation, Weizmann Institute of Science, Hertzl Street 1, Rehovot, 76100, Israel

    Gabi Tarcic

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Hoeller, D., Dikic, I. (2013). Efficient Enhancement of Signalling Capacity: The Ubiquitin System. In: Yarden, Y., Tarcic, G. (eds) Vesicle Trafficking in Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6528-7_9

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