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Efficient Enhancement of Signaling Capacity: Signaling Endosomes

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Vesicle Trafficking in Cancer

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Abstract

The concept of signaling endosomes originated from the observations that receptors activated at the plasma membrane can continue signaling after their endocytic internalization into endosomal compartments. In this chapter we discuss how the unique features of endosomes, such as their biochemical properties, regulated cytoskeleton-mediated transport or heterogeneity, can be exploited to modulate signal transduction. While endosomes may regulate the magnitude, kinetics, and specificity of the signals, they can also control the intracellular localization of signaling molecules and spatial signal propagation, thus contributing to cell polarization. In particular, we describe known mechanisms by which early or late endosomes act as platforms for signal propagation, diversification, or sequestration. Finally, we review some examples of how signaling endosomes contribute to the development or physiology of multicellular organisms and how aberrations in these processes may lead to pathologies.

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  1. Laboratory of Cell Biology, International Institute of Molecular and Cell Biology, 4 Ks. Trojdena Street, 02-109, Warsaw, Poland

    Iwona Pilecka & Marta Miaczynska

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  1. Iwona Pilecka
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  2. Marta Miaczynska
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Correspondence to Iwona Pilecka .

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  1. Department of Biological Regulation, Candiotty Bldg, Hertzel St 1, Rehovot, 76100, Israel

    Yosef Yarden

  2. , Department of Biological Regulation, Weizmann Institute of Science, Hertzl Street 1, Rehovot, 76100, Israel

    Gabi Tarcic

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Pilecka, I., Miaczynska, M. (2013). Efficient Enhancement of Signaling Capacity: Signaling Endosomes. In: Yarden, Y., Tarcic, G. (eds) Vesicle Trafficking in Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6528-7_7

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