Molecular Mechanism of Ubiquitin-Dependent Traffic

  • Elena Maspero
  • Hans-Peter Wollscheid
  • Simona Polo


Posttranslational modification (PTM) of signaling receptors by the covalent attachment of one, or often more, ubiquitin (Ub) moieties has emerged as the major regulatory mechanism responsible for receptor “downregulation.” Pioneering work in yeast has demonstrated that Ub is required for the first step in cargo internalization as well as for targeting cargos to vacuoles (the yeast equivalent of lysosomes) [1, 2]. Following these initial observations, there are now numerous reports of ubiquitination of a vast array of mammalian signaling receptors, such as RTKs, GPCRs, MHC-I, NOTCH, various channels and transporters, cytokine, and interferon receptors (reviewed in [3–8]). The molecular basis of Ub-dependent regulation of receptor endocytosis is being clarified. In this chapter, we will give a general overview of the mammalian system.


Epidermal Growth Factor Receptor Epidermal Growth Factor Receptor Signaling HECT Domain Receptor Ubiquitination Epidermal Growth Factor Receptor Degradation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Research in the Polo laboratory is supported by grants from the Associazione Italiana per la Ricerca sul Cancro, the Italian University Research Program for the Development of Research of National Interest and of Health (PRIN), the Association of International Cancer Research, the CARIPLO Foundation, and the EMBO Young Investigator Program. HPW is recipient of a Marie Curie/AIRC Cofund International Fellowship.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Elena Maspero
    • 1
  • Hans-Peter Wollscheid
    • 2
  • Simona Polo
    • 1
    • 2
  1. 1.IFOM, Fondazione Istituto FIRC di Oncologia MolecolareMilanItaly
  2. 2.Dipartimento di Medicina, Chirurgia ed OdontoiatriaUniversita’ degli Studi di MilanoMilanItaly

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